Zu "K04833" wurden 73 Artikel gefunden!
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Aprindine hydrochloride
Artikelnummer: TGM-T21373-25mg
Description: Aprindine HCl is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally. Target: Others. Smiles: Cl.C=1C=CC(=CC1)N(CCCN(CC)CC)C2CC=3C=CC=CC3C2....
| Schlagworte: | Aprindine HCl, Aprindina, Fibocil, Aprinidine, Fiboran, Amidonal, Aprindin |
| Anwendung: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 33237-74-0 |
| MW: | 358.95 D |
ab 1.491,00 €
Flecainide
Artikelnummer: TGM-T21391-50mg
Description: Flecainide acetate is a class Ic antiarrhythmic agent, it is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia. It works by regulating the flow of sodium in the heart, causing prolongation of the...
| Schlagworte: | Flecainida, Apocard, Tambocor, Flecainidum |
| Anwendung: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 54143-55-4 |
| MW: | 414.34 D |
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Disopyramide phosphate
Artikelnummer: TGM-T21424-25mg
Description: Disopyramide, a sodium channel blocker in the Class of 1a anti-arrhythmic agent, is used in the treatment of Ventricular Tachycardia. Disopyramide has a negative inotropic effect on the ventricular myocardium, resulting in a significant decrease in contractility. Target: Others. Smiles:...
| Schlagworte: | SC-13957, SC 13957, SC13957 |
| Anwendung: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 22059-60-5 |
| MW: | 437.47 D |
ab 1.491,00 €
Mephenytoin
Artikelnummer: TGM-T21425-1mg
Description: Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6. Target: P450. Smiles: C(C)C1(C(=O)N(C)C(=O)N1)C2=CC=CC=C2. References: Vijayabhaskar V, Srivastava P, Rajagopal S. Breaking the sensitivity limitations of cytochrome P450 oxidation product: dansyl chloride...
| Schlagworte: | Methylphenetoin, Methoin, Insulton, Phenantoin, Mesantoin |
| Anwendung: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 50-12-4 |
| MW: | 218.25 D |
ab 36,00 €
Mexiletine
Artikelnummer: TGM-T21427-25mg
Description: Mexiletine is a non-selective voltage-gated sodium channel blocker. It is a medicine in the class of IB anti-arrhythmic. Mexiletine may also be used in patients experiencing refractory pain and is effective to treat muscle stiffness resulting from myotonic dystrophy or non-dystrophic myotonias. Target:...
| Schlagworte: | KO 1173, KO1173, KO-1173, Mexitil, Mexiletene |
| Anwendung: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 31828-71-4 |
| MW: | 179.26 D |
ab 1.491,00 €
Phenytoin-d10
Artikelnummer: TGM-T68918-1mg
Description: Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a...
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, voltage-gated sodium channel inhibitor |
| CAS | 65854-97-9 |
| MW: | 262.33 D |
55,00 €
Fosphenytoin disodium
Artikelnummer: TGM-T7066-100mg
Description: Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker. Target: Sodium Channel. Smiles: O.[Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C1=O)(c1ccccc1)c1ccccc1. References: Smith R D , Brown B S , Maher R W , et al. Pharmacology...
| Schlagworte: | ACC-9653, Fosphenytoin sodium |
| Anwendung: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 92134-98-0 |
| MW: | 406.24 D |
ab 39,00 €
Eleclazine free base
Artikelnummer: TGM-T71945-10mg
Description: Eleclazine, also known as GS-6615, is a selective late sodium current inhibitor. Eleclazine is potentially useful for treatment of coronary vasodilators, antiarrhythmics and vasodilators. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and end of the...
| Anwendung: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 1443211-72-0 |
| MW: | 415.37 D |
ab 64,00 €
Flecainide acetate
Artikelnummer: TGM-T7219-100mg
Description: Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormally fast heart rhythms). Target: Sodium Channel. Smiles: CC(O)=O.FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC1CCCCN1. References: Kohli, Vikas. Oral flecainide is effective in management of...
| Schlagworte: | R-818, Flecainide (acetate) |
| Anwendung: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 54143-56-5 |
| MW: | 474.39 D |
ab 48,00 €
AA43279
Artikelnummer: TGM-T71854-10mg
Description: AA43279 is a novel selective Nav1.1 activator, increasing the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increasing the spontaneous inhibitory post-synaptic currents (sIPSCs) recorded from pyramidal neurons. Target: Others. Smiles: COc1ccc(cc1)-c1cc(N)c(s1)C(N)=O
| Anwendung: | Nav1.1 activator |
| CAS | 354812-16-1 |
| MW: | 248.3 D |
ab 120,00 €
Pirmenol
Artikelnummer: TGM-T7531-100mg
Description: Pirmenol is a new antiarrhythmic drug. Target: Others. Smiles: C(CCCN1[C@H](C)CCC[C@@H]1C)(O)(C2=CC=CC=C2)C3=CC=CC=N3. References: Ciaravino V, Kropko ML, Krishna G,et al.Genotoxicity assessment of pirmenol, a new antiarrhythmic drug.Mutat Res. 1992,280(3):205-14.
| Anwendung: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 68252-19-7 |
| MW: | 338.49 D |
ab 50,00 €
Licarbazepine
Artikelnummer: TGM-T7806-100mg
Description: Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders. Target: Others. Smiles: NC(=O)N1c2ccccc2CC(O)c2ccccc12. References: Begas E , Tsakalof A , Dardiotis E , et al....
| Schlagworte: | 10,11-hydroxy-10,11 Dihydrocarbamezer |
| Anwendung: | Anticonvulsant, voltage-gated sodium channel SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A blocker |
| CAS | 29331-92-8 |
| MW: | 254.28 D |
ab 44,00 €