Zu "K04815" wurden 17 Artikel gefunden!
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(±)-Nicotine
Artikelnummer: Cay16535-500
(±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs, Kis = 481 and 11.1 nM for alpha3beta4 and alpha4beta2 subtypes, respectively) and possesses addictive and teratogenic properties. (-)-(S)-Nicotine is...
| Schlagworte: | DL-Nicotine, 3-(1-methyl-2-pyrrolidinyl)-pyridine |
| Anwendung: | nAChR agonist |
| CAS | 22083-74-5 |
| MW: | 162.2 D |
ab 149,00 €
SIB-1553A hydrochloride
Artikelnummer: TGM-T16881-100mg
Description: SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.SIB-1553A hydrochloride enhances cognition and may be useful in the study of Alzheimer's disease and cognitive impairment. Target: AChR. Smiles:...
| Anwendung: | nAChR agonist |
| CAS | 191611-89-9 |
| MW: | 273.82 D |
ab 93,00 €
Mecamylamine (hydrochloride)
Artikelnummer: Cay14602-50
Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the alpha3beta4 subtype (IC50 = 90-640 nM) compared to alpha4beta2, alpha3beta2, and alpha7 subtypes (IC50 range from 1-7 µM). Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic...
| Schlagworte: | Inversine, N,2,3,3-tetramethyl-bicyclo[2.2.1]heptan-2-amine, monohydrochloride |
| Anwendung: | Nicotinic acetylcholine receptor antagonist |
| CAS | 826-39-1 |
| MW: | 203.8 D |
ab 61,00 €
SIB 1553A (hydrochloride)
Artikelnummer: Cay14973-1
SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for beta4 subunit-containing receptors. Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals.Formal Name:...
| Schlagworte: | 4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]-phenol, monohydrochloride |
| Anwendung: | nAChR agonist |
| CAS | 191611-89-9 |
| MW: | 273.8 D |
ab 44,00 €
(-)-Cytisine
Artikelnummer: CDX-C0228-M100
Light yellow powder/crystals. Soluble in toluene. Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities. Used for smoking...
| Schlagworte: | NSC 407282, BRN 0083882, Baptitoxine, Sophorine,... |
| Anwendung: | Nicotine agonist, Iron chelator, Hydroxyl radical scavanger |
| CAS | 485-35-8 |
| MW: | 190,2 D |
ab 168,00 €
SR 16584
Artikelnummer: Cay10683-1
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels in the central and peripheral nervous system. SR 16584 is an antagonist of the alpha3beta4 nAChR subtype (IC50 = 10.2 µM). It shows selective binding of the alpha3beta4 subtype compared to the alpha4beta2 and alpha7 subtypes (Ki values of...
| Schlagworte: | 3-dihydro-1-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-2H-indol-2-one |
| Anwendung: | alpha3beta4 nAChR antagonist |
| CAS | 1150153-86-8 |
| MW: | 270.4 D |
ab 45,00 €
ABT-594 (hydrochloride)
Artikelnummer: Cay22822-25
ABT-594 is a potent agonist of neuronal alpha4beta2 subunit-containing nicotinic acetylcholine receptors (nAChRs, Ki = 37 pM in a radioligand binding assay). It is selective for neuronal nAChRs over neuromuscular alpha1beta1deltagamma subunit-containing nAChRs (Ki = 10,000 nM), alpha1B-, alpha2B-, and alpha2C-...
| Schlagworte: | Ebanicline, Tebanicline, 5-[(2R)-2-azetidinylmethoxy]-2-chloro-pyridine, monohydrochloride |
| Anwendung: | Nicotinic acetylcholine receptor partial agonist |
| CAS | 203564-54-9 |
| MW: | 235.1 D |
ab 52,00 €
Adiphenine (hydrochloride)
Artikelnummer: Cay31124-10
Adiphenine is an anticholinergic agent. It is an antagonist of nicotinic acetylcholine receptors (nAChRs, IC50s = 1.8, 3.7, and 6.3 µM for the alpha3beta4, alpha4beta2, and alpha4beta4 subunit-containing receptors, respectively), as well as muscarinic acetylcholine receptors (Ki = 0.44 µM). Adiphenine inhibits...
| Schlagworte: | NSC 129224, Spasmolytin, Trasentin, alpha-phenyl-benzeneacetic acid, 2-(diethylamino)ethyl ester, monohydrochloride |
| Anwendung: | Anticholinergic agent, smooth muscle relaxant |
| CAS | 50-42-0 |
| MW: | 347.9 D |
ab 49,00 €
alpha-Conotoxin AuIB (trifluoroacetate salt)
Artikelnummer: Cay33795-500
alpha-Conotoxin AuIB is a conotoxin that has been found in C. aulicus and has receptor antagonist and analgesic activity. It is a peptide antagonist of alpha3beta4 subunit-containing nicotinic acetylcholine receptors (nAChRs, IC50 = 0.75 µM). It is greater than 100-fold selective for alpha3beta4 subunit-containing...
| Schlagworte: | GCCSYPPCFATNPDC, cyclic (2->8), (3->15)-bis(disulfide),... |
| Anwendung: | Alpha3beta4 subunit-containing nAChR antagonist, conotoxin |
| MW: | 1572.8 D |
ab 582,00 €
Human ACHB4 full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP100796.10
This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or...
| Schlagworte: | CHRNB4, Neuronal acetylcholine receptor subunit beta-4 |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 56.4 kD |
ab 1.291,00 €
Human ACHB4-Strep full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP120796.10
This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or...
| Schlagworte: | CHRNB4, Neuronal acetylcholine receptor subunit beta-4 |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 56.4 kD |
ab 1.162,00 €
SR 16584
Artikelnummer: TGM-T23388-1mg
Description: alpha3beta4 nAChR antagonist. Target: Others. Smiles: O=C1N(C=2C(C1)=CC=CC2)[C@@H]3C[C@@]4(N(C)[C@](C3)(CCC4)[H])[H]. References: Solt L A, Kumar N, He Y, et al. Identification of a selective RORgamma ligand that suppresses Th17 cells and stimulates T regulatory cells[J]. ACS chemical biology, 2012,...
| Anwendung: | alpha3beta4 nAChR antagonist |
| CAS | 1150153-86-8 |
| MW: | 270.37 D |
ab 83,00 €