Zu "K04733" wurden 55 Artikel gefunden!
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IRAK4 (human, recombinant)
Artikelnummer: Cay42144-100
IL-1 receptor-associated kinase 4 (IRAK4) is a serine/threonine kinase involved in Toll/IL-1 receptor (TIR) signaling. It is composed of an N-terminal death domain, which is involved in dimerization and interaction with MyD88, a proline/serine/threonine-rich domain, and a C-terminal kinase domain. IRAK4 is...
| Schlagworte: | IRAK4, IRAK-4, IRAK-4, Renal carcinoma antigen NY-REN-64, Renal carcinoma antigen NY-REN-64, Interleukin-1... |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
ab 1.499,00 €
Zimlovisertib
Artikelnummer: TGM-TQ0167-100mg
Description: Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4 nM in the cell and PBMC assay). Target: IRAK. Smiles: O(C[C@@H]1[C@H](CC)[C@H](F)C(=O)N1)C=2C3=C(C=C(C(N)=O)C(OC)=C3)C=CN2. References: Lee KL, et...
| Schlagworte: | PF06650833, PF-06650833 |
| Anwendung: | Targets interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1] (IRAK4) |
| CAS | 1817626-54-2 |
| MW: | 361.37 D |
ab 41,00 €
IRAK inhibitor 4
Artikelnummer: TGM-T11672-100mg
Description: IRAK inhibitor 4 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). Target: Others. Smiles: CC(C)CCNC(=O)c1ccc2n(C3CCC(O)CC3)c(Nc3n[nH]c4ccc(cc34)-c3ccccc3OC(F)(F)F)nc2c1. References: Marinho FV, et al. Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses...
| Anwendung: | IRAK inhibitor |
| CAS | 1012104-68-5 |
| MW: | 620.66 D |
ab 1.521,00 €
AZ1495
Artikelnummer: TGM-T14367-100mg
Description: AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL). Target: Haspin Kinase, CDK, IRAK. Smiles:...
| Anwendung: | IRAK4 inhibitor |
| CAS | 2196204-23-4 |
| MW: | 385.5 D |
ab 148,00 €
IRAK inhibitor 1
Artikelnummer: TGM-T5094-100mg
Description: IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 µM) and JNK-2 (IC50>10 µM). Target: JNK, IRAK. Smiles: C1CC(CCN1)Nc1cccc(n1)-c1cnc2ccccn12. References: Buckley GM, et al. IRAK-4 inhibitors. Part II: A structure-based assessment of...
| Anwendung: | IRAK inhibitor |
| CAS | 1042224-63-4 |
| MW: | 293.37 D |
ab 89,00 €
IRAK inhibitor 6
Artikelnummer: TGM-T5110-100mg
Description: IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor-associated kinase 4 [IRAK-4, IC50: 160 nM]. Target: IRAK. Smiles: COc1cc(ccc1NC(=O)c1csc(n1)-c1cccnc1)N1CCOCC1. References: Buckley G, et al. IRAK-4 inhibitors. Part 1: a series of amides. Bioorg Med Chem Lett. 2008 Jun 1,18(11):3211-4.
| Anwendung: | IRAK inhibitor |
| CAS | 1042672-97-8 |
| MW: | 396.46 D |
ab 50,00 €
IRAK4-IN-1
Artikelnummer: TGM-T4140-100mg
Description: IRAK4-IN-1 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. Target: IRAK. Smiles: N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1. References: Smith GF, et al. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorg Med...
| Anwendung: | IRAK4 inhibitor |
| CAS | 1820787-94-7 |
| MW: | 337.42 D |
ab 64,00 €
AS-2444697
Artikelnummer: TGM-T4299-100mg
Description: AS-2444697 is an inhibitor of IRAK-4 (C50 = 21 nM). AS-2444697 exhibits renoprotective effects through anti-inflammatory action. AS-2444697 potently inhibits human and rat IRAK-4 activity. Target: IRAK. Smiles: Cl.Cc1cc(ccn1)-c1nc(co1)C(=O)Nc1cn(nc1C(N)=O)C1CCOCC1. References: Mitsuhiro Kondo, et al....
| Anwendung: | IRAK4 inhibitor |
| CAS | 1287665-60-4 |
| MW: | 432.86 D |
ab 40,00 €
IRAK4-IN-7
Artikelnummer: TGM-T5354-100mg
Description: IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model. Target: IRAK. Smiles: Nc1ccc(cn1)-c1cccc(n1)C(=O)Nc1cnc2nc(oc2c1)N1CCOCC1. References: Robert N. Booher, et al. Abstract 1168: Efficacy of the IRAK4 inhibitor CA-4948 in...
| Schlagworte: | CA-4948 |
| Anwendung: | IRAK-4 inhibitor |
| CAS | 1801343-74-7 |
| MW: | 417.42 D |
ab 34,00 €
IRAK inhibitor 2
Artikelnummer: TGM-T7368-100mg
Description: IRAK inhibitor 2 (IRAK-IN-2) is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK-4) for the study of inflammation-related diseases. Target: IRAK. Smiles: Oc1ccc(cc1)-c1cnc2ccc(NCc3ccco3)nn12. References: Allahyari M,et al. IRAK inhibitor can improve insulin sensitivity in...
| Schlagworte: | IRAK-IN-2 |
| Anwendung: | IRAK inhibitor |
| CAS | 928333-30-6 |
| MW: | 306.32 D |
ab 79,00 €
IRAK-4 protein kinase inhibitor 2
Artikelnummer: TGM-T9631-100mg
Description: IRAK-4 protein kinase inhibitor 2 is a potent inhibitor of interleukin-1 receptor-associated kinase-4 (IC50 = 4 µM). Target: IRAK. Smiles: [O-][N+](=O)c1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1. References: Powers JP, et, al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4....
| Anwendung: | IRAK-4 protein kinase inhibitor |
| CAS | 301675-24-1 |
| MW: | 282.25 D |
ab 41,00 €
CA-4948
Artikelnummer: TGM-T9027-100mg
Description: CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity. Target: IRAK, FLT. Smiles: Cc1cc(ccn1)-c1nc(co1)C(=O)Nc1cc2oc(nc2nc1N1CC[C@@H](O)C1)N1CCOCC1. References: Wiese MD, et al. Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis. Expert Opin...
| Schlagworte: | Emavusertib |
| Anwendung: | Targets interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1] (IRAK4) |
| CAS | 1801344-14-8 |
| MW: | 491.5 D |
ab 33,00 €