Zu "K04730" wurden 60 Artikel gefunden!
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JNJ-1013
Artikelnummer: Cay41740-1
JNJ-1013 is a proteolysis-targeting chimera (PROTAC) containing the IL-1 receptor-associated kinase 1 (IRAK1) and IRAK4 inhibitor JH-I-25 and a methylated derivative of the PROTAC building block VH 032 (Cay-39982). It degrades IRAK1 with a half-maximal degradation concentration (DC50) value of 3.3 nM in HBL-1...
| Schlagworte: | N-(4-(4-(2-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimet... |
| Anwendung: | IRAK1 degradation driving PROTAC |
| CAS | 2597343-08-1 |
| MW: | 878.1 D |
ab 78,00 €
IRAK inhibitor 3
Artikelnummer: TGM-T11670-100mg
Description: IRAK inhibitor 3 is a modulator of interleukin-1 (IL-1) receptor-associated kinase (IRAK). Target: IRAK. Smiles: COc1ccc(cc1OC)-c1cnc2ccc(NCc3ccc(cc3)S(N)(=O)=O)nn12. References: Thomas Durand-Reville, et al. Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune...
| Anwendung: | IRAK inhibitor |
| CAS | 1012343-93-9 |
| MW: | 439.49 D |
ab 142,00 €
Anti-IRAK1
Artikelnummer: CSB-PA003061.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-IRAK, Anti-IRAK1, Anti-IRAK-1, EC=2.7.11.1, Anti-Interleukin-1 receptor-associated kinase 1, AA48924 antibody, Il1rak... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-IRAK1
Artikelnummer: CSB-PA011235.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-IRAK, Anti-IRAK1, Anti-IRAK-1, EC=2.7.11.1, Anti-Interleukin-1 receptor-associated kinase 1, AA48924 antibody, Il1rak... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 126,00 €
Anti-IRAK1
Artikelnummer: CSB-PA101009.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-IRAK, Anti-IRAK1, Anti-IRAK-1, EC=2.7.11.1, Anti-Interleukin-1 receptor-associated kinase 1, AA48924 antibody, Il1rak... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
283,00 €
Anti-Phospho-IRAK1 (Ser376)
Artikelnummer: CSB-PA274948.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits with...
| Schlagworte: | Anti-phospho-IRAK, Anti-phospho-IRAK1, Anti-phospho-IRAK-1, EC=2.7.11.1, Anti-phospho-Interleukin-1 receptor-associated... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
340,00 €
Anti-IRAK-1
Artikelnummer: Cay13843-1
Nuclear factor-kappaB (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF-alpha, and LPS. A...
| Schlagworte: | Interleukin-1 Receptor-Associated Kinase 1 |
| Anwendung: | IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
425,00 €
Anti-IRAK1
Artikelnummer: A303-743A-T
Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88...
| Schlagworte: | Anti-IRAK, Anti-IRAK1, Anti-IRAK-1, EC=2.7.11.1, Anti-Interleukin-1 receptor-associated kinase 1 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
IRAK-1/4 Inhibitor
Artikelnummer: Cay17540-1
Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. Dysregulation of TIR signaling, typified by increased NF-kappaB activity, results in the development of some cancers and other diseases, making the development of IRAK...
| Schlagworte: | N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro-benzamide |
| Anwendung: | IRAK1 inhibitor, IRAK4 inhibitor |
| CAS | 509093-47-4 |
| MW: | 395.4 D |
ab 44,00 €
Anti-IRAK
Artikelnummer: ARG57418.50
Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88...
| Schlagworte: | Anti-IRAK, Anti-IRAK1, Anti-IRAK-1, EC=2.7.11.1, Anti-Interleukin-1 receptor-associated kinase 1 |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
559,00 €
Anti-IRAK1
Artikelnummer: A303-744A
Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88...
| Schlagworte: | Anti-IRAK, Anti-IRAK1, Anti-IRAK-1, EC=2.7.11.1, Anti-Interleukin-1 receptor-associated kinase 1 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
IRAK1, His-tag
Artikelnummer: BPS-40202
Human interleukin-1 receptor-associated kinase 1 (IRAK1), GenBank Accession No. NM_001569, a.a 186-530, with N-terminal His-tag, MW = 40 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | IRAK, IRAK-1, EC=2.7.11.1, Interleukin-1 receptor-associated kinase 1, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 40 kD |
551,00 €