Zu "K04728" wurden 99 Artikel gefunden!
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Anti-phospho-ATM Protein Kinase (Ser1981), clone 10H11.E12
Artikelnummer: 200-301-400
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of...
| Schlagworte: | Anti-phospho-ATM, Anti-phospho-A-T mutated, EC=2.7.11.1, Anti-phospho-Serine-protein kinase ATM, Anti-phospho-Ataxia... |
| Anwendung: | ELISA, FC, IHC, IFM, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
ab 180,00 €
AZ32
Artikelnummer: TGM-T4443-100mg
Description: AZ32 is an orally bioavailable, blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for the ATM enzyme and an IC50 of 0.31 µM for ATM in cells. Target: ATM/ATR. Smiles: CNC(=O)c1ccc(cc1)-c1cnc2cnc(cn12)-c1ccccc1. References: Karlin J, et al. Orally Bioavailable and Blood-Brain...
| Anwendung: | ATM inhibitor |
| CAS | 2288709-96-4 |
| MW: | 328.37 D |
ab 51,00 €
azd1390
Artikelnummer: TGM-T5175-100mg
Description: AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes. Target: ATM/ATR. Smiles: CC(C)n1c2c(cnc3cc(F)c(cc23)-c2ccc(OCCCN3CCCCC3)nc2)n(C)c1=O. References: Durant ST, et al. The brain-penetrant...
| Anwendung: | ATM kinase inhibitor |
| CAS | 2089288-03-7 |
| MW: | 477.57 D |
ab 78,00 €
CP-466722
Artikelnummer: TGM-T6261-100mg
Description: CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells. Target: ATM/ATR. Smiles: COc1cc2ncnc(-n3nc(nc3N)-c3ccccn3)c2cc1OC. References: Rainey MD, et al. Cancer Res, 2008, 68(18), 7466-7474.
| Schlagworte: | CP466722, CP 466722 |
| Anwendung: | ATM inhibitor |
| CAS | 1080622-86-1 |
| MW: | 349.35 D |
ab 31,00 €
CGK733
Artikelnummer: TGM-T1821-100mg
Description: CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR. Target: ATM/ATR. Smiles: [O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c2ccccc2)C(Cl)(Cl)Cl)ccc1F. References: Won J, et al. Nat Chem Biol, 2006, 2(7), 369-374.
| Schlagworte: | CGK 733 |
| Anwendung: | ATM inhibitor |
| CAS | 905973-89-9 |
| MW: | 555.84 D |
ab 31,00 €
KU-60019
Artikelnummer: TGM-T63872-100mg
Description: KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM). Target: ATM/ATR. Smiles: C[C@H]1CN(CC(=O)Nc2ccc3Sc4c(Cc3c2)cccc4-c2cc(=O)cc(o2)N2CCOCC2)C[C@@H](C)O1. References: Golding SE, et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK...
| Anwendung: | ATM kinase inhibitor |
| CAS | 925701-46-8 |
| MW: | 547.67 D |
ab 33,00 €
AZD0156
Artikelnummer: TGM-T6770-100mg
Description: AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing. Target: Apoptosis, ATM/ATR. Smiles: CN(C)CCCOc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCOCC4)c3c2c1. References: WO2015170081A1 - Imidazo[4,5-c]quinolin-2-one compounds and their...
| Anwendung: | ATM kinase inhibitor |
| CAS | 1821428-35-6 |
| MW: | 461.56 D |
ab 32,00 €
ATM Inhibitor-1
Artikelnummer: TGM-T10396-100mg
Description: ATM Inhibitor-1 is a highly potent, selective, and orally active ATM inhibitor (IC50: 0.7 nM) with anti-tumor activity. It exhibits weak activity against mTOR (IC50, 21 µM), DNAPK (IC50, 2.8 µM), PI3Kalpha (IC50, 3.8 µM), PI3Kbeta (IC50, 10.3 µM), PI3Kgamma (IC50, 3 µM), and PI3Kdelta (IC50, 0.73 µM)....
| Anwendung: | ATM inhibitor |
| CAS | 2135639-94-8 |
| MW: | 492.61 D |
ab 2.375,00 €
Anti-ATM
Artikelnummer: CSB-PA020042.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-ATM, Anti-A-T mutated, Anti-Serine-protein kinase ATM, Anti-Ataxia telangiectasia mutated, A-T mutated antibody, A-T... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 106,00 €
Anti-ATM Monoclonal
Artikelnummer: CSB-MA341522.100
Host Species: Mouse. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen....
| Schlagworte: | Anti-ATM, Anti-A-T mutated, Anti-Serine-protein kinase ATM, Anti-Ataxia telangiectasia mutated, ATM, ATM Monoclonal Antibody |
| Anwendung: | ELISA, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Anti-ATM Monoclonal
Artikelnummer: CSB-MA429116.100
Host Species: Mouse. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen....
| Schlagworte: | Anti-ATM, Anti-A-T mutated, Anti-Serine-protein kinase ATM, Anti-Ataxia telangiectasia mutated, ATM, ATM Monoclonal Antibody |
| Anwendung: | ELISA, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Anti-ATM Monoclonal
Artikelnummer: CSB-MA974761.100
Host Species: Mouse. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen....
| Schlagworte: | Anti-ATM, Anti-A-T mutated, Anti-Serine-protein kinase ATM, Anti-Ataxia telangiectasia mutated, ATM, ATM Monoclonal Antibody |
| Anwendung: | ELISA, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €