Zu "K04718" wurden 124 Artikel gefunden!
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K145 hydrochloride
Artikelnummer: TGM-TQ0138-5mg
Description: K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity. Target: S1P Receptor, Apoptosis. Smiles: Cl.CCCCOc1ccc(CC\C=C2/SC(=O)N(CCN)C2=O)cc1....
| Anwendung: | SphK2 inhibitor |
| CAS | 1449240-68-9 |
| MW: | 384.92 D |
ab 49,00 €
Opaganib
Artikelnummer: AG-CR1-3749-M025
Opaganib is a selective inhibitor of sphingosine kinase 2 (SPHK2, Ki = 9.8 µM), a lipid kinase that catalyzes formation of the lipid signaling molecule sphingosine 1-phosphate (S1P). S1P promotes cancer growth, and proliferation and pathological inflammation, including TNF-alpha signaling and other inflammatory...
| Schlagworte: | 3-(4-Chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide, ABC294640, Yeliva |
| Anwendung: | SPHK2 inhibitor |
| CAS | 915385-81-8 |
| MW: | 380.9 D |
ab 99,00 €
Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant...
Artikelnummer: TGM-TMPY-04431-50ug
Description: Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 70.3 kDa and the accession number is Q9NYA1-1.
| Schlagworte: | SPHK, SPHK1, SPK, sphingosine kinase 1 |
| MW: | 70.3 kD |
497,00 €
Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant
Artikelnummer: TGM-TMPY-04432-50ug
Description: Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.7 kDa and the accession number is Q9NYA1-1.
| Schlagworte: | SPHK, SPHK1, sphingosine kinase 1, SPK |
| MW: | 42.7 kD |
497,00 €
SKI II
Artikelnummer: TGM-T6673-100mg
Description: SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 µM) while exhibiting no inhibitory action on other kinases including PKCalpha, PI3K, and ERK2. Target: Wnt/beta-catenin, Apoptosis, S1P Receptor. Smiles: Oc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)cc1. References:...
| Schlagworte: | SphK-I2 |
| Anwendung: | SPHK1 inhibitor |
| CAS | 312636-16-1 |
| MW: | 302.78 D |
ab 34,00 €
Opaganib
Artikelnummer: TGM-T6750-100mg
Description: Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 µM). Target: S1P Receptor. Smiles: Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2. References: French KJ, et al. J Pharmacol Exp Ther. 2010, 333(1), 129-139.
| Schlagworte: | ABC294640 |
| Anwendung: | SPHK2 inhibitor |
| CAS | 915385-81-8 |
| MW: | 380.91 D |
ab 34,00 €
MP-A08
Artikelnummer: TGM-T16128-100mg
Description: MP-A08 is a highly selective, ATP-competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 [Ki: 6.9 ± 0.8 µM and 27 ± 3 µM, respectively]. Target: S1P Receptor. Smiles: Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1\C=N\c1ccccc1NS(=O)(=O)c1ccc(C)cc1. References: Pitman MR et al. A selective...
| Anwendung: | SphK1 / SphK2 inhibitor |
| CAS | 219832-49-2 |
| MW: | 519.64 D |
ab 34,00 €
SKI 5C
Artikelnummer: TGM-T24803-10mg
Description: SKI 5C is a selective inhibitor of Sphingosine Kinase 1. Target: Others. Smiles: C(OC(C)(C)C)(=O)N1[C@H](C(C#CCCCCCCCCC CCCC)=O)COC1(C)C. References: Li ZH, Tao YF, Xu LX, Zhao H, Li XL, Fang F, Wu Y, Lu J, Li YH, Du WW, Ren JL, Li YP, Xu YY, Feng X, Wang J, He WQ, Pan J. A novel sphingosine kinase 1...
| Schlagworte: | SKI5C, SKI-5C |
| Anwendung: | SPHK 1 inhibitor |
| CAS | 120005-55-2 |
| MW: | 435.64 D |
ab 67,00 €
K6PC-5
Artikelnummer: TGM-T27710-100mg
Description: K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and...
| Schlagworte: | K6PC5, K6PC 5 |
| Anwendung: | SPHK1 activator |
| CAS | 756875-51-1 |
| MW: | 343.5 D |
ab 34,00 €
SLC5111312 HCl
Artikelnummer: TGM-T28803-1mg
Description: SLC5111312 is an inhibitor of SphK1 and SphK2. Target: Others. Smiles: C(=N)(N)N1[C@@H]([C@@H](O)CC1)C2=NC(=NO2)C3=CC4=C(C=C3)C=C(OCCCCC)C=C4.Cl. References: Kharel Y, Morris EA, Congdon MD, Thorpe SB, Tomsig JL, Santos WL, Lynch KR. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate...
| Schlagworte: | SLC5111312 hydrochloride, SLC 5111312, SLC-5111312, SLC5111312 |
| Anwendung: | SPHK1 / SPHK2 inhibitor |
| CAS | 1870811-01-0 |
| MW: | 445.94 D |
ab 142,00 €
SLM6031434 HCl
Artikelnummer: TGM-T28806-10mg
Description: SLM6031434 is selective inhibitor of SphK2. Target: Others. Smiles: C(=N)(N)N1[C@@H](CCC1)C2=NC(=NO2)C3=CC(C(F)(F)F)=C(OCCCCCCCC)C=C3.Cl
| Schlagworte: | SLM 6031434, SLM6031434, SLM-6031434 |
| Anwendung: | SPHK2 inhibitor |
| CAS | 1897379-34-8 |
| MW: | 489.96 D |
ab 128,00 €
MHP
Artikelnummer: TGM-T4658-100mg
Description: Methyl caprooyl tyrosinate (MHP) is an activator of sphingosine kinase (SPHK1) and significantly stimulates CAMP mRNA and protein production in KC. Target: S1P Receptor. Smiles: CCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC. References: Jeong SK, et al. Sphingosine kinase 1 activation enhances epidermal innate...
| Schlagworte: | Methyl caprooyl tyrosinate |
| Anwendung: | SPHK1 activator |
| CAS | 1104874-94-3 |
| MW: | 293.36 D |
ab 40,00 €