Zu "K04718" wurden 136 Artikel gefunden!
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MHP
Artikelnummer: TGM-T4658-100mg
Description: Methyl caprooyl tyrosinate (MHP) is an activator of sphingosine kinase (SPHK1) and significantly stimulates CAMP mRNA and protein production in KC. Target: S1P Receptor. Smiles: CCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC. References: Jeong SK, et al. Sphingosine kinase 1 activation enhances epidermal innate...
| Schlagworte: | Methyl caprooyl tyrosinate |
| Anwendung: | SPHK1 activator |
| CAS | 1104874-94-3 |
| MW: | 293.36 D |
ab 39,00 €
SLM6031434 (free base)
Artikelnummer: TGM-T70071-10mg
Description: SLM6031434 (free base) is an inhibitor of sphingosine kinase type 2 (SphK2). It consists of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group. Target: Others. Smiles: C(=N)(N)N1[C@@H](CCC1)C2=NC(=NO2)C3=CC(C(F)(F)F)=C(OCCCCCCCC)C=C3
| Anwendung: | SPHK2 inhibitor |
| CAS | 1897379-33-7 |
| MW: | 453.5 D |
ab 125,00 €
SKI-178
Artikelnummer: TGM-T9014-100mg
Description: SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 µM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of...
| Anwendung: | Sphingosine kinase inhibitor |
| CAS | 1259484-97-3 |
| MW: | 394.42 D |
ab 41,00 €
PF-543 hydrochloride
Artikelnummer: TGM-T8840-100mg
Description: PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. Target: Autophagy, S1P Receptor, Apoptosis, LPL Receptor. Smiles: Cl.Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1....
| Schlagworte: | PF-543 |
| Anwendung: | Sphingosine kinase 1 inhibitor |
| CAS | 1706522-79-3 |
| MW: | 502.1 D |
ab 33,00 €
Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant...
Artikelnummer: TGM-TMPY-04431-50ug
Description: Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 70.3 kDa and the accession number is Q9NYA1-1.
| Schlagworte: | SPHK, SPHK1, SPK, sphingosine kinase 1 |
| MW: | 70.3 kD |
487,00 €
Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant
Artikelnummer: TGM-TMPY-04432-50ug
Description: Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.7 kDa and the accession number is Q9NYA1-1.
| Schlagworte: | SPHK, SPHK1, sphingosine kinase 1, SPK |
| MW: | 42.7 kD |
487,00 €
K145 hydrochloride
Artikelnummer: TGM-TQ0138-10mg
Description: K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity. Target: S1P Receptor, Apoptosis. Smiles: Cl.CCCCOc1ccc(CC\C=C2/SC(=O)N(CCN)C2=O)cc1....
| Anwendung: | SphK2 inhibitor |
| CAS | 1449240-68-9 |
| MW: | 384.92 D |
ab 50,00 €
SKI II
Artikelnummer: TGM-T6673-100mg
Description: SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 µM) while exhibiting no inhibitory action on other kinases including PKCalpha, PI3K, and ERK2. Target: Wnt/beta-catenin, Apoptosis, S1P Receptor. Smiles: Oc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)cc1. References:...
| Schlagworte: | SphK-I2 |
| Anwendung: | SPHK1 inhibitor |
| CAS | 312636-16-1 |
| MW: | 302.78 D |
ab 39,00 €
Opaganib
Artikelnummer: TGM-T6750-100mg
Description: Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 µM). Target: S1P Receptor. Smiles: Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2. References: French KJ, et al. J Pharmacol Exp Ther. 2010, 333(1), 129-139.
| Schlagworte: | ABC294640 |
| Anwendung: | SPHK2 inhibitor |
| CAS | 915385-81-8 |
| MW: | 380.91 D |
ab 34,00 €
MP-A08
Artikelnummer: TGM-T16128-100mg
Description: MP-A08 is a highly selective, ATP-competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 [Ki: 6.9 ± 0.8 µM and 27 ± 3 µM, respectively]. Target: S1P Receptor. Smiles: Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1\C=N\c1ccccc1NS(=O)(=O)c1ccc(C)cc1. References: Pitman MR et al. A selective...
| Anwendung: | SphK1 / SphK2 inhibitor |
| CAS | 219832-49-2 |
| MW: | 519.64 D |
ab 39,00 €
SKI 5C
Artikelnummer: TGM-T24803-10mg
Description: SKI 5C is a selective inhibitor of Sphingosine Kinase 1. Target: Others. Smiles: C(OC(C)(C)C)(=O)N1[C@H](C(C#CCCCCCCCCC CCCC)=O)COC1(C)C. References: Li ZH, Tao YF, Xu LX, Zhao H, Li XL, Fang F, Wu Y, Lu J, Li YH, Du WW, Ren JL, Li YP, Xu YY, Feng X, Wang J, He WQ, Pan J. A novel sphingosine kinase 1...
| Schlagworte: | SKI5C, SKI-5C |
| Anwendung: | SPHK 1 inhibitor |
| CAS | 120005-55-2 |
| MW: | 435.64 D |
ab 67,00 €
K6PC-5
Artikelnummer: TGM-T27710-100mg
Description: K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and...
| Schlagworte: | K6PC5, K6PC 5 |
| Anwendung: | SPHK1 activator |
| CAS | 756875-51-1 |
| MW: | 343.5 D |
ab 34,00 €