Zu "K04702" wurden 81 Artikel gefunden!
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(Z)-SMI-4a
Artikelnummer: TGM-T3058-100mg
Description: (Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM. Target: Pim. Smiles: FC(F)(F)C1=CC=CC(\C=C2\SC(=O)NC2=O)=C1. References: Beharry Z, et al. Mol Cancer Ther, 2009, 8(6), 1473-1483.
| Schlagworte: | SMI-4a, TCS PIM-1 4a |
| Anwendung: | Pim-1/Pim-2 kinase inhibitor |
| CAS | 438190-29-5 |
| MW: | 273.23 D |
ab 46,00 €
SGI-1776
Artikelnummer: TGM-T3078-100mg
Description: SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias. Target: Pim, Autophagy, FLT, Apoptosis. Smiles: CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1. References: Chen LS, et al. Blood, 2011,...
| Schlagworte: | Pim-Kinase Inhibitor IX, SGI-1776 free base |
| Anwendung: | Pim1 / Pim2 / Pim3 inhibitor |
| CAS | 1025065-69-3 |
| MW: | 405.42 D |
ab 48,00 €
SMI-16a
Artikelnummer: TGM-T3989-100mg
Description: SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM) while exhibiting little or no activity against a panel of 57 other kinases (=18% inhibition at 5 µM). Target: Pim. Smiles:...
| Schlagworte: | PIM1/2 Kinase Inhibitor VI |
| Anwendung: | Pim-1 kinase inhibitor |
| CAS | 587852-28-6 |
| MW: | 263.31 D |
ab 31,00 €
TCS-PIM-1-4a
Artikelnummer: TGM-T4215-100mg
Description: TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 µM). Target: Pim, Apoptosis. Smiles: C(=C1SC(=O)NC1=O)C2=CC(C(F)(F)F)=CC=C2. References: Lin YW, et al. A small molecule inhibitor of Pim...
| Schlagworte: | SMI-4a |
| Anwendung: | Pim-1/Pim-2 kinase inhibitor |
| CAS | 327033-36-3 |
| MW: | 273.23 D |
ab 46,00 €
TP-3654
Artikelnummer: TGM-T4523-100mg
Description: TP-3654, a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM). Target: Pim. Smiles: CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1. References: Foulks JM, et al. A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas....
| Anwendung: | Pim kinase inhibitor |
| CAS | 1361951-15-6 |
| MW: | 418.46 D |
ab 52,00 €
Pim-1 kinase inhibitor 3
Artikelnummer: TGM-T61074-100mg
Description: Pim-1 kinase inhibitor 3 (Compound H5) is a potent inhibitor of Pim-1 kinase with an inhibitory concentration (IC50) of 35.13 nM [1]. Target: Others. Smiles: C1=2N3C=4C(OC1=CC=C(C2)OCCCCNCCCCC3)=CN=CC4
| Anwendung: | Pim1 kinase inhibitor |
| CAS | 2801695-39-4 |
| MW: | 339.43 D |
ab 1.520,00 €
Pim-1 kinase inhibitor 2
Artikelnummer: TGM-T62001-100mg
Description: Pim-1 kinase inhibitor 2 (Compound 13) is a potent inhibitor of Pim-1 kinase with potential for cancer research due to its ability to induce apoptosis [1]. Target: Others. Smiles: O=C1N(C(=O)C=2C1=CC=CC2)C3=CC=C(C=C3)C4=CC(=C(C#N)C(N)=N4)C5=CC=CO5
| Anwendung: | Pim1 kinase inhibitor |
| CAS | 2543624-91-3 |
| MW: | 406.39 D |
ab 1.520,00 €
Quercetagetin
Artikelnummer: TGM-T8114-100mg
Description: Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 µM). Target: Pim. Smiles: Oc1ccc(cc1O)-c1oc2cc(O)c(O)c(O)c2c(=O)c1O. References: Yang X, et al. Isolation...
| Schlagworte: | 6-Hydroxyquercetin |
| Anwendung: | Pim-1 inhibitor |
| CAS | 90-18-6 |
| MW: | 318.24 D |
ab 89,00 €
Pim-1 kinase inhibitor 8
Artikelnummer: TGM-T83627-100mg
Description: Pim-1 kinase inhibitor 8 is a potent Pim-1 kinase inhibitor with anticancer activity and can effectively inhibit cell migration.Pim-1 kinase inhibitor 8 is cytotoxic to MCF-7 and HepG2 cells, and is a candidate compound for breast cancer research. Target: PKC, Pim. Smiles:...
| Anwendung: | Pim1 kinase inhibitor |
| CAS | 916038-47-6 |
| MW: | 275.3 D |
ab 57,00 €
Pim-1/2 kinase inhibitor 1
Artikelnummer: TGM-T9229-100mg
Description: Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable...
| Anwendung: | Pim1/Pim2 kinase inhibitor |
| CAS | 6320-51-0 |
| MW: | 235.26 D |
ab 34,00 €
CX-6258
Artikelnummer: TGM-T1834-100mg
Description: CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity. Target: Pim. Smiles: CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1. References: Haddach M, et al. ACS Medicinal Chemistry Letters, 3 (2) , 135-139
| Schlagworte: | CX 6258 |
| Anwendung: | Pim kinase inhibitor |
| CAS | 1202916-90-2 |
| MW: | 461.94 D |
ab 31,00 €
Pim-1 kinase inhibitor 1
Artikelnummer: TGM-T60972-100mg
Description: Pim-1 kinase inhibitor 1 can be used in cancer research, showing anticancer activity against a variety of cancer cell lines by promoting cell apoptosis. Pim-1 kinase inhibitor 1 is an inhibitor of Pim-1 kinase with an IC 50 value of 0.11 µM [1]. Target: Others. Smiles:...
| Anwendung: | Pim1 kinase inhibitor |
| CAS | 2803505-57-7 |
| MW: | 331.32 D |
ab 1.520,00 €