Zu "K04692" wurden 211 Artikel gefunden!
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5,15-DPP
Artikelnummer: TGM-T21501-5mg
Description: 5,15-Diphenylporphyrin (5,15-DPP) is a selective STAT3-SH2 antagonist with IC50 values of 0.28 µM for STAT3 and 10 µM for STAT1 [1]. Target: Others. Smiles: c1cc2nc1cc1ccc([nH]1)c(-c1ccccc1)c1ccc(cc3ccc([nH]3)c2-c2ccccc2)n1
| Anwendung: | STAT3 dimerization inhibitor |
| CAS | 22112-89-6 |
| MW: | 462.54 D |
38,00 €
MM-206
Artikelnummer: TGM-T28075-10mg
Description: MM-206, a cell-permeable, non-cytotoxic naphthalene sulfonamide compound, it effectively inhibits STAT3 DNA-binding activity. Target: Others. Smiles: N(S(=O)(=O)C1=C(F)C(F)=C(F)C(F)=C1F)C=2C3=C(C(O)=C(SC4=CC=CC=C4)C2)C=CC=C3
| Anwendung: | STAT3 inhibitor |
| CAS | 1809581-87-0 |
| MW: | 497.46 D |
ab 208,00 €
ML115
Artikelnummer: TGM-T35544-100mg
Description: ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFkappaB anti-targets. Target: STAT. Smiles: COc1cc(NC(=O)c2cc(on2)C2CC2)c(OC)cc1Cl. References: Madoux F, et al. Modulators of STAT Transcription Factors for the...
| Anwendung: | Cell-permeable STAT3 activator |
| CAS | 912798-42-6 |
| MW: | 322.74 D |
ab 94,00 €
CAY10784
Artikelnummer: TGM-T36035-10mg
Description: CAY10784 is a STAT3 inhibitor (IC50= 0.74 µM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 µM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 µM for both)....
| Anwendung: | STAT3 inhibitor |
| CAS | 1245814-52-1 |
| MW: | 317.24 D |
ab 140,00 €
BP-1-102
Artikelnummer: TGM-T3708-100mg
Description: BP-1-102 is an orally active, effective, and specific STAT3 inhibitor that binds Stat3 (Kd: 504 nM), blocks Stat3-phosphotyrosine (pTyr) peptide interactions and Stat3 activation (4-6.8 µM), and selectively inhibits the migration, survival, growth, and invasion of Stat3-dependent tumor cells. The...
| Anwendung: | STAT3 inhibitor |
| CAS | 1334493-07-0 |
| MW: | 626.59 D |
ab 33,00 €
C188-9
Artikelnummer: TGM-T4650-100mg
Description: C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 µM. Target: STAT, Apoptosis. Smiles: COc1ccc(cc1)S(=O)(=O)Nc1cc(c(O)c2ccccc12)-c1c(O)ccc2ccccc12. References: edell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by...
| Schlagworte: | TTI-101 |
| Anwendung: | STAT3 inhibitor |
| CAS | 432001-19-9 |
| MW: | 471.52 D |
ab 38,00 €
HJC0152 hydrochloride
Artikelnummer: TGM-T4234-10mg
Description: HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor. Target: Apoptosis, STAT. Smiles: Cl.NCCOc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O. References: Chen H, et al. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally...
| Schlagworte: | HJC0152 |
| Anwendung: | STAT3 inhibitor |
| CAS | 1420290-99-8 |
| MW: | 406.64 D |
ab 33,00 €
Stattic
Artikelnummer: TGM-T6308-100mg
Description: Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 µM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis. Target: Apoptosis, STAT. Smiles: [O-][N+](=O)C1=CC=C2C=CS(=O)(=O)C2=C1. References: Guo H, et al....
| Schlagworte: | STAT3 Inhibitor V |
| Anwendung: | STAT3 inhibitor |
| CAS | 19983-44-9 |
| MW: | 211.19 D |
ab 31,00 €
FLLL32
Artikelnummer: TGM-T6838-100mg
Description: FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 µM). Target: Apoptosis, STAT, JAK. Smiles: COc1ccc(\C=C\C(=O)C2(CCCCC2)C(=O)\C=C\c2ccc(OC)c(OC)c2)cc1OC. References: Lin L, et al. Cancer Res. 2010, 70(6), 2445-2454.
| Anwendung: | STAT3 inhibitor |
| CAS | 1226895-15-3 |
| MW: | 464.55 D |
ab 38,00 €
STAT3 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-06624-100ug
Description: STAT3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 65.31 kDa and the accession number is P40763-1.
| Schlagworte: | signal transducer and activator of transcription 3 (acute-phase response factor), ADMIO, HIES, APRF |
| MW: | 65.31 kD |
ab 587,00 €
Cucurbitacin I
Artikelnummer: TGM-TQ0196-1mg
Description: Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity. Target: STAT, JAK. Smiles: [H][C@@]12CC=C3[C@@]([H])(C=C(O)C(=O)C3(C)C)[C@]1(C)C(=O)C[C@]1(C)[C@H]([C@H](O)C[C@@]21C)[C@@](C)(O)C(=O)\C=C\C(C)(C)O. References: Song J, et al. Cucurbitacin I...
| Schlagworte: | JSI-124, NSC-521777, Elatericin B |
| Anwendung: | STAT3/JAK signaling pathway inhibitor |
| CAS | 2222-07-3 |
| MW: | 514.65 D |
ab 76,00 €
SH5-07
Artikelnummer: TGM-TQ0052-100mg
Description: SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 µM). Target: STAT. Smiles: CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(cc1)C(=O)NO)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F. References: Yue P,et al. Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In...
| Anwendung: | STAT3 inhibitor |
| CAS | 1456632-41-9 |
| MW: | 625.61 D |
ab 51,00 €