Zu "K04674" wurden 111 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
SB-431542 (hydrate)
Artikelnummer: Cay13031-25
SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene...
| Schlagworte: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate |
| Anwendung: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
| MW: | 384.4 D |
ab 44,00 €
ALK5 Inhibitor II
Artikelnummer: Cay14794-25
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when...
| Schlagworte: | E 616452, RepSox, SJN 2511, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
| Anwendung: | ALK5 inhibitor |
| CAS | 446859-33-2 |
| MW: | 287.3 D |
ab 36,00 €
SB 525334
Artikelnummer: TGM-T1763-5mg
Description: SB-525334 is a potent and selective inhibitor of the TGF-beta1R and ALK5 (IC50: 14.3 nM). Target: ALK, TGF-beta/Smad. Smiles: C(C)(C)(C)C=1NC(=C(N1)C=2N=C(C)C=CC2)C3=CC4=C(C=C3)N=CC=N4. References: Grygielko ET, et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth...
| Schlagworte: | SB525334 |
| Anwendung: | TGFBR1 inhibitor |
| CAS | 356559-20-1 |
| MW: | 343.42 D |
ab 33,00 €
LY-364947
Artikelnummer: TGM-T2048-100mg
Description: LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFbetaR-I. Target: MLK, Casein Kinase, TGF-beta/Smad, RIP kinase. Smiles: N1C=C(C(=N1)C1=NC=CC=C1)C1=CC=NC2=CC=CC=C12. References: Li HY, et al. J Med Chem, 2006, 49(6), 2138-2142.
| Schlagworte: | HTS466284, LY 364947 |
| Anwendung: | TGFbetaRI inhibitor |
| CAS | 396129-53-6 |
| MW: | 272.3 D |
ab 60,00 €
SD-208
Artikelnummer: TGM-T2109-100mg
Description: SD-208 (ALK5 Inhibitor V), a selective TGF-betaRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-betaRII. Target: TGF-beta/Smad. Smiles: Fc1ccc(Cl)cc1-c1nc(Nc2ccncc2)c2nccnc2n1. References: Uhl M, et al. Cancer Res. 2004, 64(21), 7954-7961.
| Schlagworte: | ALK5 Inhibitor V, SD208 |
| Anwendung: | TGFBR1 inhibitor |
| CAS | 627536-09-8 |
| MW: | 352.75 D |
ab 34,00 €
A 77-01
Artikelnummer: TGM-T2098-1mg
Description: A 77-01 is a potent inhibitor of the TGF-(beta) type I receptor superfamily activin-like kinase ALK5, with an IC50 of 25 nM. Target: ALK, TGF-beta/Smad. Smiles: Cc1cccc(n1)-c1n[nH]cc1-c1ccnc2ccccc12. References: Tojo M, et al. Y Sci. 2005 Nov,96(11):791-800.
| Schlagworte: | A77-01 |
| Anwendung: | ALK5 inhibitor |
| CAS | 607737-87-1 |
| MW: | 286.33 D |
ab 42,00 €
A 83-01
Artikelnummer: TGM-T3031-100mg
Description: A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-beta type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cultures. Target: ALK, TGF-beta/Smad. Smiles:...
| Schlagworte: | A8301, ALK5 Inhibitor IV |
| Anwendung: | TGFBR1 inhibitor |
| CAS | 909910-43-6 |
| MW: | 421.52 D |
ab 52,00 €
LY3200882
Artikelnummer: TGM-T5125-100mg
Description: LY3200882 is a highly selective inhibitor of TGF-beta receptor type 1 (TGFbetaRI). Target: TGF-beta/Smad. Smiles: CC(C)(O)c1cc(Nc2cc(Oc3cn(nc3C3CCOCC3)C3CC3)ccn2)ccn1. References: Huaxing Pei, et al. Abstract 955: LY3200882, a novel, highly selective TGFbetaRI small molecule inhibitor. AACR, Cancer Res...
| Anwendung: | TGFR-1 inhibitor |
| CAS | 1898283-02-7 |
| MW: | 435.52 D |
ab 40,00 €
BIBF0775
Artikelnummer: TGM-T5197-100mg
Description: BIBF0775 is a selective TGFbeta type I receptor (Alk5) inhibitor (IC50: 34 nM). Target: ALK, TGF-beta/Smad. Smiles: CCN(C)C(=O)c1ccc2\C(=C(\Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1. References: Roth GJ, et al. Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth...
| Anwendung: | ALK5 inhibitor |
| CAS | 334951-90-5 |
| MW: | 494.63 D |
ab 37,00 €
SM 16
Artikelnummer: TGM-T4975-100mg
Description: SM 16 is an ALK5/ALK4 kinase inhibitor with Ki values of 10 nM and 1.5 nM, respectively. Target: ALK, TGF-beta/Smad. Smiles: Cc1cccc(n1)-c1[nH]c(nc1-c1ccc2OCOc2c1)C12CCC(CC1)(CC2)C(N)=O. References: Suzuki E, et al. A novel small-molecule inhibitor of transforming growth factor beta type I receptor...
| Anwendung: | TGFBR1/ALK5 inhibitor |
| CAS | 614749-78-9 |
| MW: | 430.5 D |
ab 40,00 €
TGFBR1 Protein, Mouse, Recombinant (hFc)
Artikelnummer: TGM-TMPJ-01178-10ug
Description: TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3....
| Schlagworte: | AAT5, tbetaR-I, TGF-beta receptor type I, SKR4, TGFBR1, TGFR-1, ACVRLK4, LDS2A, TGF-bRI, TGFB1R1, TGFbetaRI, LDS1A,... |
| MW: | 60 kD |
ab 140,00 €
TGFBR1 Protein, Human, Recombinant (mFc & Avi)
Artikelnummer: TGM-TMPK-00305-100ug
Description: transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR-98-5p. miR-98-5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299...
| Schlagworte: | TGFbetaRI, TGFbetaRI, tbetaR-I, ALK-5, LDS2A, TGFR-1, tbetaR-I, TGF-beta RI, TGF-beta RI, SKR4, TGF-bRI, ACVRLK4, LDS1A,... |
| MW: | 38.2 kD |
ab 627,00 €