Zu "K04605" wurden 46 Artikel gefunden!
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LY379268
Artikelnummer: Cay15351-10
LY379268 is a potent, brain-permeable, and selective agonist of group II metabotropic glutamate receptors (mGluRs), subtypes mGluR2 and mGluR3. In an assay of second messenger response, LY379268 exhibits EC50 values of 2.69 and 4.48 nM for human mGluR2 and mGluR3, respectively, with at least 80-fold selectivity over...
| Schlagworte: | (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid |
| Anwendung: | mGluR2 / mGluR3 agonist |
| CAS | 191471-52-0 |
| MW: | 187.2 D |
ab 69,00 €
Talaglumetad hydrochloride
Artikelnummer: TGM-T60611-100mg
Description: Talaglumetad hydrochloride is a prodrug of Eglumegad which is the potent and selective agonist of the type II metabotropic glutamate receptor (mGluR2/3) to treat with psychiatric disorders. Target: Others. Smiles: Cl.[H][C@@]12CC[C@@](NC(=O)[C@H](C)N)(C(O)=O)[C@]1([H])[C@H]2C(O)=O
| Anwendung: | Targets metabotropic glutamate receptor 2 (GRM2) |
| CAS | 441765-97-5 |
| MW: | 292.72 D |
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Pomaglumetad methionil anhydrous
Artikelnummer: TGM-T11907-100mg
Description: LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agonist. Target: GluR. Smiles: N(C([C@H](CCSC)N)=O)[C@]1(C(O)=O)[C@]2([C@]([C@@H]2C(O)=O)(S(=O)(=O)C1)[H])[H]. References: Lowe S, et al. Effects...
| Schlagworte: | LY2140023 |
| Anwendung: | Targets metabotropic glutamate receptor 2 (GRM2) |
| CAS | 635318-55-7 |
| MW: | 366.41 D |
ab 1.474,00 €
Pomaglumetad methionil
Artikelnummer: TGM-T12520-100mg
Description: Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039. Target: GluR. Smiles: N(C([C@H](CCSC)N)=O)[C@]1(C(O)=O)[C@]2([C@]([C@@H]2C(O)=O)(S(=O)(=O)C1)[H])[H].O. References: Adams DH, et al. A long-term, phase 2, multicenter, randomized,...
| Schlagworte: | LY2140023 hydrate |
| Anwendung: | Targets metabotropic glutamate receptor 2 (GRM2) |
| CAS | 956385-05-0 |
| MW: | 384.43 D |
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Biphenylindanone A
Artikelnummer: TGM-T14615-10mg
Description: Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders. Target: GluR. Smiles: Cc1c2C(=O)C(Cc2cc(OCc2cccc(c2)-c2ccc(cc2)C(O)=O)c1C)C1CCCC1. References: Rowe BA, et al. Transposition of three amino acids transforms the human metabotropic...
| Schlagworte: | BINA |
| Anwendung: | mGluR2 modulator |
| CAS | 866823-73-6 |
| MW: | 454.56 D |
ab 264,00 €
Xanthurenic Acid
Artikelnummer: TGM-T3010-100mg
Description: Xanthurenic Acid (8-Hydroxykynurenic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3). Target: GluR, Endogenous Metabolite, Apoptosis. Smiles: OC(=O)c1cc(O)c2cccc(O)c2n1. References:...
| Schlagworte: | xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid |
| Anwendung: | Tryptophan degradation product, endogenous mGluR2 / mGluR3 agonist |
| CAS | 59-00-7 |
| MW: | 205.17 D |
ab 31,00 €
JNJ-42153605
Artikelnummer: TGM-T3451-100mg
Description: JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM). Target: GluR. Smiles: FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1. References: Cid JM, et al. Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a...
| Anwendung: | Positive allosteric mGlu2 receptor modulator |
| CAS | 1254977-87-1 |
| MW: | 400.44 D |
ab 30,00 €
GRM2 (human) full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP100135.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Schlagworte: | mGluR2, GPRC1B, Metabotropic glutamate receptor 2, GLUR2, GPRC1B, mGlu2, MGLUR2, Human GRM2 full length... |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 95.6 kD |
ab 1.291,00 €
Biphenylindanone A
Artikelnummer: Cay11986-25
The metabotropic glutamate receptor 2 (mGluR2) is a Gi/o-coupled receptor which is expressed on presynaptic nerve terminals and modulates the release of neurotransmitters like glutamate and GABA. Biphenylindanone A (BINA) is a positive allosteric modulator of mGluR2, stimulating the human and rat receptors with EC50...
| Schlagworte: | BINA, MRLSD 230, 3'-[[(2-cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic... |
| Anwendung: | mGluR2 modulator |
| CAS | 866823-73-6 |
| MW: | 454.6 D |
ab 145,00 €
LY341495
Artikelnummer: Cay14693-10
LY341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4...
| Schlagworte: | alphaS-amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid |
| Anwendung: | Group II mGluR antagonist |
| CAS | 201943-63-7 |
| MW: | 353.4 D |
ab 61,00 €
LY404039
Artikelnummer: Cay18408-25
LY404039 is a potent agonist of metabotropic glutamate (mGlu) group II receptors mGluR2 and mGluR3 (Kis = 149 and 62 nM, respectively, for recombinant human isoforms). It displays 100-fold selectivity for mGluR2/3 over ionotropic glutamate receptors, glutamate transporters, and several other receptors targeted by...
| Schlagworte: | (1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide |
| Anwendung: | mGluR-2 & mGluR-3 agonist |
| CAS | 635318-11-5 |
| MW: | 235.2 D |
ab 44,00 €
Xanthurenic Acid
Artikelnummer: Cay19191-500
Xanthurenic acid is formed upon tryptophan degradation by indoleamine 2,3-dioxygenase. It has been shown to be an endogenous Group II metabotropic glutamate receptor (mGluR2 and mGluR3) agonist and is implicated in the pathophysiology of schizophrenia. Xanthurenic acid has also been identified as an inducer of...
| Schlagworte: | NSC 401570, Xanthurenate, 4,8-dihydroxy-2-quinolinecarboxylic acid |
| Anwendung: | Tryptophan degradation product, endogenous mGluR2 / mGluR3 agonist |
| CAS | 59-00-7 |
| MW: | 205.2 D |
ab 44,00 €