Zu "K04604" wurden 79 Artikel gefunden!
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HexylHIBO (hydrobromide)
Artikelnummer: Cay29164-1
HexylHIBO is an antagonist of group I metabotropic glutamate receptors (mGluRs, Kbs = 140 and 110 µM for mGluR1alpha and mGluR5a, respectively). It is selective for group I mGluRs over mGluR2 (group II) and mGluR4a (group III) (Kbs = >1,000 µM for both), as well as AMPA, NMDA, and kainate receptors (IC50s = >100 µM...
| Schlagworte: | Hexylhomoibotenic Acid, alpha-amino-4-hexyl-2,3-dihydro-3-oxo-5-isoxazolepropanoic acid, monohydrobromide |
| Anwendung: | MGluR antagonist |
| MW: | 337.2 D |
ab 171,00 €
MFZ 10-7
Artikelnummer: Cay42024-1
MFZ 10-7 is a negative allosteric modulator (NAM) and inverse agonist of metabotropic glutamate receptor 5 (mGluR5). It selectively binds to mGluR5 (Ki = 0.67 nM) over a panel of 63 additional receptors and ion channels at 100 nM. MFZ 10-7 reduces D-myo-inositol 1 phosphate (1-IP1, Cay-1000777) accumulation, a...
| Schlagworte: | 3-fluoro-5-[2-(6-methyl-2-pyridinyl)ethynyl]-benzonitrile |
| Anwendung: | MGluR5 negative allosteric modulator/inverse agonist |
| CAS | 1224431-15-5 |
| MW: | 236.2 D |
ab 44,00 €
ADX-47273
Artikelnummer: TGM-T2053-100mg
Description: ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM). Target: GluR. Smiles: Fc1ccc(cc1)C(=O)N1CCC[C@@H](C1)c1nc(no1)-c1ccc(F)cc1. References: Liu F, et al. J Pharmacol Exp Ther, 2008, 327(3), 827-839.
| Schlagworte: | BA 94673139 |
| Anwendung: | Positive allosteric mGluR5 modulator |
| CAS | 851881-60-2 |
| MW: | 369.36 D |
ab 34,00 €
Fenobam hydrate
Artikelnummer: TGM-T68959-10mg
Description: Fenobam hydrate is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5). It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate and inhibits basal activity of mGluR5. Fenobam reduces stress-induced hyperthermia, exhibits...
| Anwendung: | Targets metabotropic glutamate receptor 5 (GRM5) |
| CAS | 63540-28-3 |
| MW: | 284.7 D |
ab 77,00 €
MTEP hydrochloride
Artikelnummer: TGM-T7515-100mg
Description: MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively). Target: GluR. Smiles: Cl.Cc1nc(cs1)C#Cc1cccnc1. References: NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in...
| Schlagworte: | 3-((2-Methyl-1,3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride, MTEP |
| Anwendung: | mGlu5a receptor antagonist |
| CAS | 1186195-60-7 |
| MW: | 236.72 D |
ab 37,00 €
MTEP
Artikelnummer: TGM-T73568-100mg
Description: MTEP, a potent, non-competitive, and highly selective antagonist of mGluR5, exhibits an IC50 value of 5 nM and a K_i value of 16 nM. Demonstrating antidepressant and anxiolytic-like effects, MTEP is utilized in Parkinson's disease research. Target: Others. Smiles: C(#CC=1C=CC=NC1)C2=CSC(C)=N2
| Anwendung: | mGluR antagonist |
| CAS | 329205-68-7 |
| MW: | 200.26 D |
ab 1.520,00 €
VU0029251
Artikelnummer: TGM-T78600-10mg
Description: VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 µM. It also attenuates glutamate-induced calcium mobilization in HEK293 cell membranes that express rat mGluR5, demonstrating an IC 50 of 1.7 µM [1]. Target: Others. Smiles: CSC1=NC2=C(C3=C(CCC3)S2)C(N)=N1
| Anwendung: | Partial mGluR5 antagonist |
| CAS | 330819-85-7 |
| MW: | 237.34 D |
ab 65,00 €
GRM5 Protein, Human, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-01663-100ug
Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates...
| Schlagworte: | GRM5, Metabotropic glutamate receptor 5 |
| MW: | 70.6 kD |
ab 281,00 €
VU 0357121
Artikelnummer: TGM-T6725-100mg
Description: VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes. Target: GluR. Smiles: CCCCOC1=CC=C(C=C1)C(=O)NC1=CC=C(F)C=C1F. References: Hammond AS, et al. ACS Chem Neurosci, 2010, 1(10), 702-716.
| Anwendung: | mGluR5 positive allosteric modulator |
| CAS | 433967-28-3 |
| MW: | 305.32 D |
ab 55,00 €
JNJ-46778212
Artikelnummer: TGM-T15619-100mg
Description: JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies. Target: GluR. Smiles: Fc1ccc(cc1)C(=O)N1CCc2nc(COc3ccccc3)oc2C1. References: Conde-Ceide S,et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator...
| Schlagworte: | VU 0409551 |
| Anwendung: | mGluR5 positive allosteric modulator |
| CAS | 1363281-27-9 |
| MW: | 352.36 D |
ab 57,00 €
AZD 9272
Artikelnummer: TGM-T14389-100mg
Description: AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux. Target: GluR. Smiles: C(#N)C=1C=C(C=C(F)C1)C2=NC(=NO2)C3=CC=C(F)C=N3. References: Swedberg MD, et al. AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by...
| Anwendung: | mGluR5 receptor negative allosteric modulator |
| CAS | 327056-26-8 |
| MW: | 284.22 D |
ab 42,00 €
Metabotropic glutamate receptor 5 (GRM5), partial, human,...
Artikelnummer: CSB-EP009935HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 22-580aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: SSERRVVAHM PGDIIIGALF SVHHQPTVDK VHERKCGAVR EQYGIQRVEA MLHTLERINS DPTLLPNITL GCEIRDSCWH SAVALEQSIE FIRDSLISSE EEEGLVRCVD...
| Schlagworte: | GRM5, GPRC1E, mGluR5, Metabotropic glutamate receptor 5, Recombinant Human Metabotropic glutamate receptor 5 (GRM5), partial |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 70.6 kD |
ab 292,00 €