Zu "K04583" wurden 58 Artikel gefunden!
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NEU
GCGR Reporter Assay System (human)
Artikelnummer: IB-IB45001
This is an all-inclusive cell-based luciferase reporter assay kit targeting the the Human Glucagon Receptor (GCGR). INDIGO's GCGR reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the GCGR. In addition to GCGR Reporter Cells, this kit provides two...
| Schlagworte: | GL-R, GCGR, Glucagon receptor |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.507,00 €
NEU
GCGR Reporter Assay System (human)
Artikelnummer: IB-IB45002
This is an all-inclusive cell-based luciferase reporter assay kit targeting the the Human Glucagon Receptor (GCGR). INDIGO's GCGR reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the GCGR. In addition to GCGR Reporter Cells, this kit provides two...
| Schlagworte: | GL-R, GCGR, Glucagon receptor |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
3.954,00 €
Taspoglutide (acetate)
Artikelnummer: Cay41258-25
Taspoglutide is an agonist of the glucagon-like peptide 1 receptor (GLP-1R, Ki = 1.1 nM for the human receptor). It induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). Taspoglutide (1 mg/animal per week) decreases blood levels of glucose and increases blood levels of insulin in an...
| Schlagworte: | [Aib8,35]hGLP-1(7-36)NH2, BIM-51077C, 8-(2-methylalanine)-35-(2-methylalanine)-36-L-argininamide-7-36-glucagon-like... |
| Anwendung: | GLP-1R agonist |
| CAS | 1022150-16-8 |
| MW: | 3339.7 D |
ab 35,00 €
Glucagon Receptor Extracellular Domain (human, recombinant)
Artikelnummer: Cay42231-1
Glucagon receptor (GCGR) is a transmembrane glycoprotein and class B G protein-coupled receptor (GPCR). It is composed of an N-terminal extracellular domain required for ligand binding, seven transmembrane domains, and a C-terminal intracellular domain. It is expressed primarily in the liver and kidney but is also...
| Schlagworte: | GCGR, GL-R, GL-R, Glucagon receptor, Glucagon receptor |
| Anwendung: | Active enzyme |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
ab 476,00 €
Skyrin
Artikelnummer: TGM-T36072-1mg
Description: Skyrin is a fungal metabolite characterized by a bisanthraquinone structure. It interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor. At 10 µM, skyrin reduces both glucagon-stimulated cAMP production and glycogenolysis. It does not interfere with...
| Schlagworte: | Rhodophyscin, Endothianin |
| Anwendung: | Antioxidant, glucagon antagonist |
| CAS | 602-06-2 |
| MW: | 538.46 D |
457,00 €
GRA Ex-25
Artikelnummer: TGM-T3422-100mg
Description: GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor. Target: Glucagon Receptor. Smiles: CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1. References: Kurukulasuriya R, et al. Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett. 2004 May 3,14(9):2047-50.
| Schlagworte: | GRA-Ex-25 |
| Anwendung: | Glucagon receptor (GCGR) antagonist |
| CAS | 307983-31-9 |
| MW: | 563.61 D |
ab 57,00 €
Glucagon Receptor Antagonist I
Artikelnummer: TGM-T37223-1mg
Description: Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR, IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after...
| Anwendung: | GCGR antagonist |
| CAS | 438618-32-7 |
| MW: | 346.53 D |
ab 329,00 €
NNC-0640
Artikelnummer: TGM-T7364-100mg
Description: NNC-0640 is a negative allosteric modulator of Human Glucagon Receptor with an IC50 of 69.2 nM. Target: Glucagon Receptor. Smiles: CS(=O)(=O)c1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)Nc2nnn[nH]2)c2ccc(cc2)C2CCCCC2)c1. References: Song G , Yang D , Wang Y , et al. Human GLP-1 receptor transmembrane domain structure...
| Anwendung: | GCGR negative allosteric modulator |
| CAS | 307986-98-7 |
| MW: | 573.67 D |
ab 42,00 €
Dasiglucagon
Artikelnummer: TGM-T77791-50mg
Description: Dasiglucagon is a stable human glucagon peptide analog that is rapid and effective in the treatment of severe hypoglycemia. Target: Others. Smiles: O=C(N(C)CC=1C=C(C=CC1C=2C=CC=CC2S(=O)(=O)NC3=NOC(=C3C)C)C4=NC=CO4)CC(C)(C)C
| Anwendung: | Targets glucagon receptor (GCGR) |
| CAS | 1544300-84-6 |
| MW: | 3381.62 D |
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GCGR Protein, Human, Recombinant (E. coli, His & Myc)
Artikelnummer: TGM-TMPH-01382-100ug
Description: GCGR Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.5 kDa and the accession number is P47871.
| Schlagworte: | GCGR, Glucagon receptor |
| MW: | 20.5 kD |
ab 359,00 €
GCGR Protein, Human, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-01383-100ug
Description: GCGR Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 18.1 kDa and the accession number is P47871.
| Schlagworte: | GCGR, Glucagon receptor |
| MW: | 18.1 kD |
ab 294,00 €
GCGR Protein, Mouse, Recombinant (GST)
Artikelnummer: TGM-TMPH-02675-100ug
Description: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting....
| Schlagworte: | Glucagon receptor, Gcgr |
| MW: | 40.8 kD |
ab 281,00 €