Zu "K04581" wurden 132 Artikel gefunden!
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NEU
Mazdutide
Artikelnummer: AG-CP3-0045-M001
Mazdutide is a novel long-acting dual glucagon-like peptide-1 (GLP-1) receptor and glucagon receptor (GCGR) agonist. Mazdutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GCG receptor (GCGR) or the GLP-1R. Mazdutide is a synthetic peptide...
| Schlagworte: | LY3305677, LY-3305677, IBI362 |
| Anwendung: | Long-acting dual glucagon-like peptide-1 (GLP-1) receptor / glucagon receptor (GCGR) agonist |
| CAS | 2259884-03-0 |
| MW: | 4563,1 D |
ab 66,00 €
NEU
Survodutide
Artikelnummer: AG-CP3-0046-M001
Survodutide is a novel long-acting dual glucagon-like peptide-1 (GLP-1) receptor and glucagon receptor (GCGR) agonist. Survodutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GCG receptor (GCGR) or the GLP-1R. Survodutide is a synthetic...
| Schlagworte: | BI-456906, EX-A7878, GTPL13383 |
| Anwendung: | Long-acting dual glucagon-like peptide-1 (GLP-1) receptor / glucagon receptor (GCGR) agonist |
| CAS | 2805997-46-8 |
| MW: | 4231,7 D |
ab 66,00 €
GLP-1R Modulator L7-028
Artikelnummer: Cay41246-1
GLP-1R modulator L7-028 is a positive allosteric modulator of the glucagon-like peptide 1 receptor (GLP-1R). It enhances GLP-1 binding to GLP-1R (EC50 = 11.01 µM) and cAMP accumulation induced by GLP-1 (7-36) in CHO cells expressing GLP-1R.Formal Name:...
| Schlagworte: | GLP-1 Receptor Modulator L7-028, Glucagon-like Peptide 1 Receptor Modulator L7-028,... |
| Anwendung: | GLP-1R positive allosteric modulator |
| CAS | 2648317-95-5 |
| MW: | 392.5 D |
ab 54,00 €
Taspoglutide (acetate)
Artikelnummer: Cay41258-10
Taspoglutide is an agonist of the glucagon-like peptide 1 receptor (GLP-1R, Ki = 1.1 nM for the human receptor). It induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). Taspoglutide (1 mg/animal per week) decreases blood levels of glucose and increases blood levels of insulin in an...
| Schlagworte: | [Aib8,35]hGLP-1(7-36)NH2, BIM-51077C, 8-(2-methylalanine)-35-(2-methylalanine)-36-L-argininamide-7-36-glucagon-like... |
| Anwendung: | GLP-1R agonist |
| CAS | 1022150-16-8 |
| MW: | 3339.7 D |
ab 35,00 €
Ecnoglutide
Artikelnummer: Cay41272-1
Ecnoglutide is a cAMP-biased peptide glucagon-like peptide 1 receptor (GLP-1R) agonist. It selectively induces cAMP accumulation over beta-arrestin recruitment (EC50s = 0.018 and 1,300 nM, respectively) without inducing GLP-1R receptor internalization (EC50 = >10,000 nM) in cell-based assays using human GLP-1R. In...
| Schlagworte: | XW003,... |
| Anwendung: | CAMP-biased peptide GLP-1R agonist |
| CAS | 2459531-73-6 |
| MW: | 4284.8 D |
ab 40,00 €
VU0453379 (hydrochloride)
Artikelnummer: Cay41392-1
VU0453379 is an allosteric agonist and positive allosteric modulator (ago-PAM) of glucagon-like peptide 1 receptor (GLP-1R). It induces calcium mobilization in 9-3-H cells expressing human GLP-1R (EC50 = 1.3 µM) and enhances GLP-1-, exenatide-, or liraglutide-induced calcium mobilization in the same cells (EC50s =...
| Schlagworte: | 2-cyclopentyl-2,9-dihydro-9-methyl-N-[[(2S)-1-(1-methylethyl)-2-pyrrolidinyl]methyl]-1-oxo-1H-pyrido[3,4-b]indole-4-carbox... |
| Anwendung: | GLP-1R allosteric agonist / positive allosteric modulator (ago-PAM) |
| MW: | 471 D |
ab 75,00 €
Exendin-4
Artikelnummer: TGM-T3967-5mg
Description: Exendin-4 (Exenatide) is a glucagon-like peptide-1 receptor (GLP-1) agonist (IC50: 3.22 nM). Exenatide is a 39 amino acid peptide. Compared to GLP-1, exenatide has a longer half-life of 2.4 hours. Target: Glucagon Receptor. Smiles:...
| Schlagworte: | Exenatide, Exenatide Acetate |
| Anwendung: | Targets glucagon-like peptide 1 receptor (GLP1R) |
| CAS | 141758-74-9 |
| MW: | 4186.57 D |
ab 57,00 €
GLP-1R Agonist DMB
Artikelnummer: TGM-T36579-10mg
Description: GLP-1R Agonist DMB is an agonist of glucagon-like peptide 1 receptor (GLP-1R, KB = 26.3 nM for the recombinant human receptor). Target: Glucagon Receptor. Smiles: CC(C)(C)Nc1nc2cc(Cl)c(Cl)cc2nc1S(C)(=O)=O. References: Koole, C., Wootten, D., Simms, J., et al. Allosteric ligands of the glucagon-like...
| Anwendung: | GLP-1R agonist |
| CAS | 281209-71-0 |
| MW: | 348.25 D |
ab 46,00 €
Shanzhiside methyl ester
Artikelnummer: TGM-T3896-10mg
Description: Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial beta-endorphin expression via the p38 MAPK signaling. Target: Glucagon Receptor. Smiles:...
| Anwendung: | Iridoid glycoside, antiinflammatory / antinociceptive agent, GLP-1R agonist |
| CAS | 64421-28-9 |
| MW: | 406.38 D |
ab 31,00 €
LSN3318839
Artikelnummer: TGM-T63166-100mg
Description: LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can be used to lower blood glucose. Target: Glucagon Receptor. Smiles:...
| Schlagworte: | LSN 3318839, LSN-3318839 |
| Anwendung: | Positive allosteric GLP-1R modulator |
| CAS | 2764704-18-7 |
| MW: | 480.39 D |
ab 212,00 €
Liraglutide
Artikelnummer: TGM-T6876-10mg
Description: Liraglutide (Liraglutida) is a synthetic analog of glucagon-like peptide-1 (GLP-1), an agonist of the GLP-1 receptor. Liraglutide can be used to treat type 2 diabetes and chronic obesity. Target: Glucagon Receptor. Smiles: CCCCCCCCCC...
| Schlagworte: | Victoza, Liraglutida, NN2211, Liraglutidum |
| Anwendung: | Targets glucagon-like peptide 1 receptor (GLP1R) |
| CAS | 204656-20-2 |
| MW: | 3751.25 D |
ab 119,00 €
Survodutide
Artikelnummer: TGM-T76559-10mg
Description: Survodutide (BI 456906) is a dual agonist of glucagon and glucagon-like peptide 1 (GLP-1) receptors (GLP Receptor) that reduces body weight in HbA1c16 diabetes. Target: Glucagon Receptor. References: Blüher M,et al. Dose-response effects on HbA1c and bodyweight reduction of survodutide, a dual...
| Schlagworte: | BI 456906 |
| Anwendung: | Targets glucagon-like peptide 1 receptor (GLP1R) |
| CAS | 2805997-46-8 |
| MW: | 4231.62 D |
ab 105,00 €