Zu "K04521" wurden 83 Artikel gefunden!
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BACE1 Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPY-00678-100ug
Description: BACE1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.8 kDa and the accession number is P56818.
| Schlagworte: | beta-site APP-cleaving enzyme 1, beta-site APP-cleaving enzyme 1, C76936 |
| MW: | 49.8 kD |
ab 599,00 €
Lanabecestat
Artikelnummer: TGM-TQ0238-1mg
Description: Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier, Lanabecestat can be used for the study of neurological diseases like Alzheimer's disease. Target: BACE. Smiles:...
| Schlagworte: | AZD3293, LY3314814 |
| Anwendung: | Targets beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46] (BACE1) |
| CAS | 1383982-64-6 |
| MW: | 412.53 D |
148,00 €
Lanabecestat camsylate
Artikelnummer: TGM-T25610-100mg
Description: Lanabecestat camsylate is used as a BACE1 Inhibitor. Target: Others. Smiles: [H][C@@]12CC[C@@](CS(O)(=O)=O)(C(=O)C1)C2(C)C.CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@@]22N=C(C)C(N)=N2)-c2cncc(c2)C#CC)CC1 ,...
| Schlagworte: | LY3314814 camsylate, LY-3314814 camsylate, LY 3314814 camsylate |
| Anwendung: | Targets beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46] (BACE1) |
| CAS | 1522418-41-2 |
| MW: | 644.83 D |
ab 1.971,00 €
AZD3839 free base
Artikelnummer: TGM-T6772-10mg
Description: AZD3839 free base is a potent and selective BACE1 inhibitor with a Ki of 26.1 nM, demonstrating approximately 14-fold selectivity over BACE2. [Phase 1]. Target: Beta-Secretase, BACE. Smiles: NC1=N[C@@](c2cccc(F)c12)(c1cccc(c1)-c1cncnc1)c1ccnc(c1)C(F)F. References: Jeppsson F, et al. J Biol Chem. 2012,...
| Schlagworte: | AZD3839 |
| Anwendung: | BACE1 inhibitor |
| CAS | 1227163-84-9 |
| MW: | 431.41 D |
ab 48,00 €
BACE-1 inhibitor 2
Artikelnummer: TGM-T62995-100mg
Description: BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1]. Target: Others. Smiles: FC=1C([C@]23[C@](CC(F)(F)C(N)=N2)(C[C@H](C)OC3)[H])=CC(NC(=O)C=4C=NC(OCF)=CN4)=CC1
| Anwendung: | BACE-1 inhibitor |
| CAS | 2563970-92-1 |
| MW: | 467.42 D |
ab 1.520,00 €
BACE-1 inhibitor 1
Artikelnummer: TGM-T10449-100mg
Description: BACE-1 inhibitor 1 (Compound 8a) is a potent BACE-1 inhibitor with an IC50 of 56 nM. Target: Others. Smiles: C(F)(F)[C@@]1(N=C(N)COC1)C2=CC(NC(=O)C3=CC=C(Br)C=N3)=CC=C2F. References: Veenstra SJ, et al. Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors. Bioorg Med Chem Lett. 2018 Jul...
| Anwendung: | BACE-1 inhibitor |
| CAS | 1262858-14-9 |
| MW: | 443.22 D |
ab 2.121,00 €
Umibecestat
Artikelnummer: TGM-T13253-100mg
Description: Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease. Target: BACE. Smiles:...
| Schlagworte: | CNP520 |
| Anwendung: | Targets beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46] (BACE1) |
| CAS | 1387560-01-1 |
| MW: | 513.8 D |
ab 175,00 €
beta-Secretase Inhibitor IV
Artikelnummer: TGM-T13434-1mg
Description: beta-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1, with IC50 values of 15.6 nM and 16.3 nM at BACE-1 concentrations of 2 nM and 100 pM, respectively. Target: Others. Smiles: C(N[C@@H](CC1=CC=CC=C1)[C@@H](CNC2CC2)O)(=O)C3=CC(C(N[C@H](C)C4=CC=CC=C4)=O)=CC(N(S(C)(=O)=O)C)=C3....
| Anwendung: | beta-Secretase inhibitor |
| CAS | 797035-11-1 |
| MW: | 578.72 D |
ab 334,00 €
Atabecestat
Artikelnummer: TGM-T14338-100mg
Description: Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Abeta reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics....
| Schlagworte: | RSC-385896, JNJ-54861911 |
| Anwendung: | Targets beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46] (BACE1) |
| CAS | 1200493-78-2 |
| MW: | 367.4 D |
ab 131,00 €
LY2811376
Artikelnummer: TGM-T2639-1mg
Description: LY2811376, an orally available non-peptidic beta-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Abeta secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin....
| Anwendung: | BACE1 inhibitor |
| CAS | 1194044-20-6 |
| MW: | 320.36 D |
ab 48,00 €
beta-Secretase Inhibitor I
Artikelnummer: TGM-T39251-5mg
Description: beta-Secretase Inhibitor I is a highly potent inhibitor of the beta-secretase enzyme. This compound exhibits exceptional inhibitory activity while also demonstrating a significant reduction in cardiovascular and liver toxicity. Target: Others. Smiles:...
| Anwendung: | beta-Secretase inhibitor |
| CAS | 1818239-19-8 |
| MW: | 425.43 D |
970,00 €
beta-Secretase Inhibitor II
Artikelnummer: TGM-T40260-25mg
Description: beta-Secretase Inhibitor II is a tripeptide aldehyde inhibitor of beta-Secretase with an inhibitory potency of IC50 = 700 nM against total Abeta and IC50 = 2.5 µM against Abeta[1-42]. This compound, with a simple structure, is particularly useful in Alzheimer's disease research. Target: Others. Smiles:...
| Anwendung: | beta-Secretase inhibitor |
| CAS | 263563-09-3 |
| MW: | 461.603 D |
1.520,00 €