Zu "K04514" wurden 87 Artikel gefunden!
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Y-27632 . dihydrochloride
Artikelnummer: AG-CR1-3564-M010
Potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor. Tumor cell invasion and metastasis suppressor. Smooth muscle relaxant. Decreases liver fibrosis by hepatic stellate cell growth inhibition. Antinociceptive. Blocks...
| Schlagworte: | Y-27632 - 2HCL, (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride |
| Anwendung: | ROCK kinase inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.2 D |
ab 55,00 €
Thiazovivin
Artikelnummer: TGM-T2155-1mg
Description: Thiazovivin, a ROCK inhibitor (IC50: 0.5 µM), increases the survival rate of hESC. Target: ROCK. Smiles: O=C(NCc1ccccc1)c1csc(Nc2ccncn2)n1. References: Xu Y, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci...
| Anwendung: | Cell-permeable ROCK inhibitor |
| CAS | 1226056-71-8 |
| MW: | 311.36 D |
ab 31,00 €
GSK180736A
Artikelnummer: TGM-T3513-100mg
Description: GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 µM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 µM), but highly effective against ROCK1 (IC50: 100 nM). Target: ROCK, GRK, PKA. Smiles: CC1=C(C(NC(=O)N1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1....
| Schlagworte: | GSK180736 |
| Anwendung: | ROCK1 inhibitor |
| CAS | 817194-38-0 |
| MW: | 365.36 D |
ab 37,00 €
Glycyl H-1152 hydrochloride
Artikelnummer: TGM-T35459-10mg
Description: Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a...
| Anwendung: | ROCK inhibitor |
| CAS | 913844-45-8 |
| MW: | 449.39 D |
ab 233,00 €
H-1152 dihydrochloride
Artikelnummer: TGM-T35328-100mg
Description: H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 µM, 5.68 µM, 0.360 µM, 0.745 µM and 0.180 µM, respectively. Target:...
| Schlagworte: | H-1152 dihydrochloride, H-1152 2HCl |
| Anwendung: | Cell-permeable ROCK inhibitor |
| CAS | 871543-07-6 |
| MW: | 392.34 D |
ab 58,00 €
ZINC00881524
Artikelnummer: TGM-T4095-100mg
Description: ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor. Target: ROCK. Smiles: COc1ccc(CC(=O)Nc2nc-3c(CCc4ccccc-34)s2)cc1OC. References: Lower, G., & Bryan, G. (1976). Enzymic deacetylation of carcinogenic arylacetamides by tissue microsomes of the dog and other species. Journal Of...
| Schlagworte: | ROCK inhibitor |
| Anwendung: | ROCK inhibitor |
| CAS | 557782-81-7 |
| MW: | 380.46 D |
ab 31,00 €
GSK-25
Artikelnummer: TGM-T4488-100mg
Description: GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). Target: S6 Kinase, mTOR, ROCK. Smiles:...
| Schlagworte: | GSK25 |
| Anwendung: | ROCK1 inhibitor |
| CAS | 874119-56-9 |
| MW: | 513.33 D |
ab 40,00 €
H-1152
Artikelnummer: TGM-T7552-10mg
Description: H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM). Target: ROCK. Smiles: S(=O)(=O)(C=1C2=C(C=CC1)C=NC=C2C)N3[C@@H](C)CNCCC3. References: Ikenoya M , Hidaka H , Hosoya T , et al. Inhibition of Rho-kinase-induced myristoylated alanine-rich C kinase substrate...
| Anwendung: | ROCK inhibition |
| CAS | 451462-58-1 |
| MW: | 319.42 D |
ab 88,00 €
ROCK-IN-2
Artikelnummer: TGM-TQ0110-100mg
Description: ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2. Target: ROCK. Smiles: Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12. References: Kast R, et al. Cardiovascular effects of a novel potent and highly selective...
| Schlagworte: | Azaindole 1, TC-S 7001 |
| Anwendung: | ROCK inhibitor |
| CAS | 867017-68-3 |
| MW: | 402.79 D |
ab 116,00 €
SR-3677
Artikelnummer: TGM-TQ0187-10mg
Description: SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM). Target: ROCK, Autophagy. Smiles: CN(C)CCOc1cc(ccc1NC(=O)C1COc2ccccc2O1)-c1cn[nH]c1. References: Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase...
| Anwendung: | ROCK inhibitor |
| CAS | 1072959-67-1 |
| MW: | 408.45 D |
ab 31,00 €
Y-27632
Artikelnummer: TGM-T1870-100mg
Description: Y-27632 is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. Target: Apoptosis, ROCK. Smiles: C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1. References: Wu Y, et al. ROCK inhibitor Y27632...
| Anwendung: | Rho kinase (ROCK) inhibitor |
| CAS | 146986-50-7 |
| MW: | 247.34 D |
ab 40,00 €
RKI-1447
Artikelnummer: TGM-T1898-100mg
Description: RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities. Target: ROCK. Smiles: Oc1cccc(CNC(=O)Nc2nc(cs2)-c2ccncc2)c1. References: Patel RA, et al. Cancer Res, 2012, 72(19), 5025-5034.
| Schlagworte: | RKI1447 |
| Anwendung: | ROCK inhibitor |
| CAS | 1342278-01-6 |
| MW: | 326.37 D |
ab 46,00 €