Zu "K04505" wurden 52 Artikel gefunden!
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GSM2
Artikelnummer: Cay41322-1
GSM2 is an inhibitor of gamma-secretase. It inhibits the production of amyloid-beta (1-42) (Abeta42) in SH-SY5Y neuroblastoma cells overexpressing SPA4CT, which is a peptide containing the N-terminal signal peptide and C-terminal residues of amyloid precursor protein (APP).Formal Name:...
| Schlagworte: | Gamma Secretase Modulator 2, gamma-Secretase Modulator 2, gamma-SM2,... |
| Anwendung: | Gamma-secretase inhibitor |
| CAS | 1093978-89-2 |
| MW: | 514.5 D |
ab 133,00 €
Anti-PSEN1
Artikelnummer: CSB-PA040015.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-AD3, Anti-PSEN1, AD3 antibody, Ad3h antibody, FAD antibody, Homo Sapiens Clone CC44 Senilin 1 antibody, Presenilin-1... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Anti-PSEN1
Artikelnummer: CSB-PA695720.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-AD3, Anti-PSEN1, AD3 antibody, Ad3h antibody, FAD antibody, Homo Sapiens Clone CC44 Senilin 1 antibody, Presenilin-1... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
275,00 €
Rat PSEN1 (Presenilin 1) ELISA Kit
Artikelnummer: ELK-ELK6153.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PSEN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PSEN1. Next,...
| Schlagworte: | Psen1, Psnl1, EC=3.4.23.- |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 365,00 €
Human PSEN1 (Presenilin 1) ELISA Kit
Artikelnummer: ELK-ELK4623.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PSEN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PSEN1. Next,...
| Schlagworte: | AD3, PSEN1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
DBZ
Artikelnummer: Cay14627-5
gamma-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Abeta), a 39- to 42-amino acid peptide which forms the amyloid plaques...
| Schlagworte: | YO-01027, Dibenzazepine,... |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 209984-56-5 |
| MW: | 463.5 D |
ab 43,00 €
MK-0752
Artikelnummer: Cay16706-10
gamma-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and beta-amyloid precursor protein (APP), within the transmembrane domain. MK-0752 is a potent, reversible inhibitor of gamma-secretase, reducing the cleavage of APP to Abeta40 in human neuroblastoma...
| Schlagworte: | cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-cyclohexanepropanoic acid |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 471905-41-6 |
| MW: | 442.9 D |
ab 92,00 €
PF-3084014
Artikelnummer: Cay27061-1
PF-3084014 is a gamma-secretase inhibitor (IC50s = 6.2 and 1.2 nM in an enzyme assay and in whole cells, respectively). It inhibits gamma-secretase activity without inducing Notch-related toxicity (EC50s = 1,300-3,000 nM for B cells in fetal thymic organ cultures). It reduces the level of amyloid-beta (1-40)...
| Schlagworte: | (2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]... |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 1290543-63-3 |
| MW: | 489.6 D |
ab 43,00 €
Compound 34
Artikelnummer: AG-CR1-0007-C200
White to off-white powder. Soluble in DMSO. Cell permeable, highly potent inhibitor of gamma-secretase (IC50 = 0.06 nM).
| Schlagworte: | (2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-1H-benzo[e][1,4]diazepin-3-yl)butyr... |
| Anwendung: | Cell-permeable gamma-secretase inhibitor |
| CAS | 564462-36-8 |
| MW: | 543,5 D |
ab 94,00 €
Anti-Presenilin1
Artikelnummer: 600-401-DS7
Anti-Presenilin1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Presenilin1 from other sources has not been determined. Protein function: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the...
| Schlagworte: | Anti-AD3, Anti-PSEN1, EC=3.4.23.- |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
684,00 €
Anti-PSEN1
Artikelnummer: E-AB-60669.120
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD...
| Schlagworte: | Anti-AD3, Anti-PSEN1, PSEN1 Polyclonal Antibody |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 198,00 €
Human PS1 (Presenilin 1) ELISA Kit
Artikelnummer: G-HUES03306.96
ELISA Type: Sandwich. Sensitivity: 0.188ng/mL. Range: 0.313--20ng/mL. Protein function: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:15274632,...
| Schlagworte: | AD3, PSEN1 |
| Anwendung: | Sandwich ELISA |
| Spezies-Reaktivität: | human |
641,00 €