Zu "K04504" wurden 81 Artikel gefunden!
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Bezafibrate
Artikelnummer: Cay10009145-1
Bezafibrate is a non-selective agonist of peroxisome proliferator-activated receptors (PPARs, EC50s = 50, 60, and 20 µM for human PPARalpha, PPARgamma, and PPARdelta, respectively). It reduces triglyceride levels and the size of lipid droplets in an oleic acid-induced HepaRG hepatocyte model of steatosis when used...
| Schlagworte: | Benzofibrate, BM 15075, 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic acid |
| Anwendung: | Non-selective PPAR agonist |
| CAS | 41859-67-0 |
| MW: | 361.8 D |
ab 31,00 €
Anti-PPARD
Artikelnummer: ABS-KC-4033.100
Protein function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter...
| Schlagworte: | Anti-Peroxisome proliferator-activated receptor delta, Anti-PPAR-delta, Anti-NUCI, Anti-Nuclear hormone receptor 1,... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, rat, mouse |
ab 206,00 €
Anti-PPARD
Artikelnummer: ABS-KC-4363.100
Protein function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter...
| Schlagworte: | Anti-Peroxisome proliferator-activated receptor delta, Anti-PPAR-delta, Anti-NUCI, Anti-Nuclear hormone receptor 1,... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, rat, mouse |
ab 206,00 €
T0070907
Artikelnummer: TGM-T6689-10mg
Description: T0070907(IC50=1 nM) , an effective and specific PPARgamma inhibitor, with the >800-fold selectivity over PPARalpha and PPARdelta. Target: PPAR. Smiles: [O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc1ccncc1. References: Lee G et al. J Biol Chem, 2002, 277(22), 19649-19657.
| Anwendung: | PPAR gamma antagonist |
| CAS | 313516-66-4 |
| MW: | 277.66 D |
ab 45,00 €
GW0742
Artikelnummer: TGM-T6524-50mg
Description: GW0742 (GW610742) is an effective and specific PPARdelta agonist (EC50: 1 nM/1.1 µM/2 µM, for human PPARdelta/alpha/gamma). Target: PPAR. Smiles: Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(c(F)c1)C(F)(F)F. References: Sznaidman ML, et al. Bioorg Med Chem Lett, 2003, 13(9), 1517-1521.
| Schlagworte: | GW610742 |
| Anwendung: | PPARdelta agonist |
| CAS | 317318-84-6 |
| MW: | 471.49 D |
ab 43,00 €
GSK0660
Artikelnummer: TGM-T2674-100mg
Description: GSK0660 is an antagonist and inverse agonist of PPARbeta/delta. Target: PPAR. Smiles: S(NC1=C(OC)C=C(NC2=CC=CC=C2)C=C1)(=O)(=O)C3=C(C(OC)=O)SC=C3. References: Savage SR, et al. Mol Vis. 2015 May 20,21:568-76.
| Anwendung: | PPARdelta antagonist |
| CAS | 1014691-61-2 |
| MW: | 418.49 D |
ab 40,00 €
CAY10592
Artikelnummer: TGM-T35813-10mg
Description: Peroxisome proliferator-activated receptors (PPARs) alpha, delta, gamma are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARdelta receptor agonists, though relatively obscure,...
| Anwendung: | PPARdelta agonist |
| CAS | 685139-10-0 |
| MW: | 568.71 D |
ab 88,00 €
L-165041
Artikelnummer: TGM-T7159-100mg
Description: L-165041 is a potent and selective agonist of the nuclear receptor PPARbeta and PPARdelta(Ki = 9 nM, EC50 = ~500 nM ,respectively). Target: PPAR. Smiles: CCCc1c(O)c(ccc1OCCCOc1ccc(OCC(O)=O)cc1)C(C)=O. References: Park J H , Lee K S , Lim H J , et al. The PPARdelta ligand L-165041 inhibits vegf-induced...
| Anwendung: | Potent, selective PPARD agonist |
| CAS | 79558-09-1 |
| MW: | 402.44 D |
ab 42,00 €
DG172 dihydrochloride
Artikelnummer: TGM-T7821-100mg
Description: DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARbeta/delta(IC50 : 27 nM). Target: PPAR. Smiles: Cl.Cl.CN1CCN(CC1)c1ccc(\C=C(/C#N)c2ccccc2Br)cc1. References: Lieber S, et al. (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable...
| Schlagworte: | DG172 (dihydrochloride), DG-172 dihydrochloride |
| Anwendung: | PPAR delta inverse agonist |
| CAS | 1361504-77-9 |
| MW: | 455.2 D |
ab 34,00 €
Ppard Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-03755-100ug
Description: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of...
| Schlagworte: | PPARD, Peroxisome proliferator-activated receptor beta, Peroxisome proliferator-activated receptor delta, Nuclear hormone... |
| MW: | 35.1 kD |
ab 281,00 €
GSK3787
Artikelnummer: TGM-T1941-100mg
Description: GSK3787 is a specific and irreversible PPARdelta inhibitor(pIC50= 6.6). Target: PPAR. Smiles: FC(F)(F)c1ccc(nc1)S(=O)(=O)CCNC(=O)c1ccc(Cl)cc1. References: Shearer BG, et al. J Med Chem, 2010, 53(4), 1857-1861.
| Anwendung: | PPARbeta/delta antagonist |
| CAS | 188591-46-0 |
| MW: | 392.78 D |
ab 49,00 €
GW 501516
Artikelnummer: TGM-T6151-10mg
Description: GW 501516 (Endurobol) is a effective and highly specifc PPARbeta/delta agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARalpha/gamma. Target: Autophagy, PPAR. Smiles: C(SC1=CC(C)=C(OCC(O)=O)C=C1)C=2SC(=NC2C)C3=CC=C(C(F)(F)F)C=C3. References: Wei ZL, et al. A short and efficient synthesis of...
| Schlagworte: | Cardarine, GW501516, GW 1516, GSK-516, Endurobol |
| Anwendung: | PPARD agonist |
| CAS | 317318-70-0 |
| MW: | 453.5 D |
ab 43,00 €