Zu "K04498" wurden 165 Artikel gefunden!
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PRI-724
Artikelnummer: Cay41728-10
PRI-724 is a prodrug form of the beta-catenin/CREB-binding protein (CBP) inhibitor C-82 and a derivative of ICG-001 (Cay-16257). It is cytotoxic to GES-1 gastric mucosal and HGC-27, MKN45, and AGS gastric cancer cells (IC50s = 16.53, 9.8, 44.28, and 3.48 µM, respectively) and enhances decreases in viability induced...
| Schlagworte: | (6S,9S,9aS)-hexahydro-2,9-dimethyl-4,7-dioxo-N-(phenylmethyl)-6-[[4-(phosphonooxy)phenyl]methyl]-8-(8-quinolinylmethyl)-2H... |
| Anwendung: | C-82 (CREB-binding protein inhibitor) prodrug |
| CAS | 1422253-38-0 |
| MW: | 658.7 D |
ab 75,00 €
I-CBP112
Artikelnummer: TGM-T3969-100mg
Description: I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains. Target: Histone Acetyltransferase, Epigenetic Reader Domain. Smiles: CCC(=O)N1CCOc2c(C1)cc(cc2OC[C@H]1CCCN(C)C1)-c1ccc(OC)c(OC)c1. References: Zucconi BE, et al....
| Anwendung: | P300 / CBP inhibitor |
| CAS | 1640282-31-0 |
| MW: | 468.59 D |
ab 30,00 €
I-CBP112 hydrochloride
Artikelnummer: TGM-T4247-100mg
Description: I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells...
| Anwendung: | CBP and EP300 inhibitor |
| CAS | 2147701-33-3 |
| MW: | 505.05 D |
ab 83,00 €
JQAD1
Artikelnummer: TGM-T41180-100mg
Description: JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC(R), DC50= 31.6 nM), comprises an EP300 inhibitor, A485, joined by a linker to a cereblon E3 ligase ligand. JQAD1 brings about degradation of EP300 in neuroblastoma cell lines in a proteasome-dependent manner. JQAD1...
| Anwendung: | PROTAC, p300 degradation |
| CAS | 2417097-18-6 |
| MW: | 932.95 D |
ab 130,00 €
Pocenbrodib
Artikelnummer: TGM-T69691-100mg
Description: Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research. Target: Epigenetic Reader Domain. Smiles: [C@H](O)(C1=NC2=C(N1[C@H]3C[C@H](C(O)=O)CCC3)C=CC4=C2CC[C@H](C)N4C(OC)=O)C5=C(OC)C=CC(F)=C5....
| Schlagworte: | P-300, FT-7051 |
| Anwendung: | Targets E1A/CREB-binding protein [EC:2.3.1.48] (EP300, CREBBP, KAT3) |
| CAS | 2304372-79-8 |
| MW: | 525.57 D |
ab 789,00 €
Histone acetyltransferase p300 Inhibitor 4c
Artikelnummer: TGM-T77560-500mg
Description: Histone acetyltransferase p300 Inhibitor 4c is a 2-aminothiazole derivative. Histone acetyltransferase p300 Inhibitor 4c inhibited hCA I, hCA II, AChE and BChE with Ki values of 0.008 ± 0.001, 0.124 ± 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 µM. 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 µM. Target: Carbonic...
| Anwendung: | Histone acetyltransferase p300 inhibitor |
| CAS | 2103-99-3 |
| MW: | 210.68 D |
ab 31,00 €
KG-501
Artikelnummer: TGM-T7297-100mg
Description: KG-501 (Naphthol AS-E phosphate) is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 µM). Target: Epigenetic Reader Domain. Smiles: C(NC1=CC=C(Cl)C=C1)(=O)C=2C(OP(=O)(O)O)=CC3=C(C2)C=CC=C3. References: Kaori K , Haruka F , Hitomi S , et al. The Traditional Japanese Herbal Medicine...
| Schlagworte: | Naphthol AS-E phosphate |
| Anwendung: | CREB - CREBBP-KIX domain interaction inhibitor |
| CAS | 18228-17-6 |
| MW: | 377.72 D |
ab 31,00 €
TTK21
Artikelnummer: TGM-T8778-100mg
Description: TTK21 is an activator of CBP/p300 histone acetyltransferase activity. Target: Epigenetic Reader Domain. Smiles: CCCOc1ccccc1C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F. References: Chatterjee, S., Mizar, P., Cassel, R., et al. A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory...
| Anwendung: | CBP/ p300 activator |
| CAS | 709676-56-2 |
| MW: | 357.75 D |
ab 55,00 €
CTB
Artikelnummer: TGM-T9541-100mg
Description: CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells. Target: Epigenetic Reader Domain. Smiles: CCOc1ccccc1C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F. References: Mantelingu K, et al. Activation of p300 histone acetyltransferase by small molecules...
| Schlagworte: | Cholera Toxin B subunit, Cholera Toxin B subunit |
| Anwendung: | p300 activator |
| CAS | 451491-47-7 |
| MW: | 343.73 D |
ab 60,00 €
NEO2734
Artikelnummer: TGM-T8658-100mg
Description: NEO2734 (EP31670) is an orally active, selective inhibitor of p300/CBP and BET bromodomains, with an IC50 of less than 30 nM for both targets. Target: Histone Acetyltransferase, Epigenetic Reader Domain. Smiles: Cc1cc(cn(C)c1=O)-c1ccc2nc(C3CCOCC3)n(CCOC(F)(F)F)c2c1. References: The novel BET-CBP/p300...
| Schlagworte: | EP31670 |
| Anwendung: | p300/CBP / BET bromodomains dual inhibitor |
| CAS | 2081072-29-7 |
| MW: | 435.44 D |
ab 116,00 €
CREBBP Protein, Human, Recombinant (GST)
Artikelnummer: TGM-TMPH-01158-100ug
Description: CREBBP Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 40.7 kDa and the accession number is Q92793.
| Schlagworte: | CREB-binding protein, CBP, CREBBP |
| MW: | 40.7 kD |
ab 236,00 €
SGC-CBP30
Artikelnummer: TGM-T6668-100mg
Description: SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM). Target: Histone Acetyltransferase, Epigenetic Reader Domain. Smiles: COc1ccc(CCc2nc3cc(ccc3n2C[C@H](C)N2CCOCC2)-c2c(C)noc2C)cc1Cl. References: Structural Genomics Consortium
| Anwendung: | CREBBP / EP300 bromodomain inhibitor |
| CAS | 1613695-14-9 |
| MW: | 509.04 D |
ab 45,00 €