Zu "K04498" wurden 161 Artikel gefunden!
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PRI-724
Artikelnummer: Cay41728-10
PRI-724 is a prodrug form of the beta-catenin/CREB-binding protein (CBP) inhibitor C-82 and a derivative of ICG-001 (Cay-16257). It is cytotoxic to GES-1 gastric mucosal and HGC-27, MKN45, and AGS gastric cancer cells (IC50s = 16.53, 9.8, 44.28, and 3.48 µM, respectively) and enhances decreases in viability induced...
| Schlagworte: | (6S,9S,9aS)-hexahydro-2,9-dimethyl-4,7-dioxo-N-(phenylmethyl)-6-[[4-(phosphonooxy)phenyl]methyl]-8-(8-quinolinylmethyl)-2H... |
| Anwendung: | C-82 (CREB-binding protein inhibitor) prodrug |
| CAS | 1422253-38-0 |
| MW: | 658.7 D |
ab 75,00 €
Histone Acetyltransferase Inhibitor II
Artikelnummer: TGM-T11563-100mg
Description: Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity in mammalian cells. Target: Epigenetic Reader Domain, Histone Acetyltransferase. Smiles: Oc1ccc(\C=C2/CCC\C(=C/c3ccc(O)c(Br)c3)C2=O)cc1Br....
| Anwendung: | Histone Acetyltransferase (p300) inhibitor |
| CAS | 932749-62-7 |
| MW: | 464.15 D |
ab 31,00 €
L002
Artikelnummer: TGM-T11807-100mg
Description: L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 µM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By blocking histone acetylation, p53 acetylation, and STAT3 activation, L002 shows...
| Anwendung: | p300 histone acetyltransferase inhibitor |
| CAS | 321695-57-2 |
| MW: | 321.35 D |
ab 34,00 €
A-485
Artikelnummer: TGM-T14073-100mg
Description: A-485 is a potent and selective catalytic p300/CBP inhibitor with IC50 values of 9.8 nM for p300 and 2.6 nM for CBP. Target: Epigenetic Reader Domain, Histone Acetyltransferase. Smiles: CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N(Cc3ccc(F)cc3)[C@@H](C)C(F)(F)F)C2=O)c1. References: Lasko LM, et al....
| Anwendung: | p300/CBP inhibitor |
| CAS | 1889279-16-6 |
| MW: | 536.48 D |
ab 88,00 €
CTPB
Artikelnummer: TGM-T15014-10mg
Description: CTPB is a potent p300 histone acetyltransferase (HAT) activator that can be used in the preparation of hair growth promoters and/or hair loss treatments. Target: Histone Acetyltransferase. Smiles: CCCCCCCCCC CCCCCc1cccc(OCC)c1C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F. References: Sivanandam M, et al. Investigation...
| Anwendung: | Potent p300 activator |
| CAS | 586976-24-1 |
| MW: | 554.13 D |
ab 64,00 €
GNE-781
Artikelnummer: TGM-T15405-100mg
Description: GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively). Target: Epigenetic Reader Domain. Smiles: CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F. References: Romero...
| Anwendung: | CBP / p300 inhibitor |
| CAS | 1936422-33-1 |
| MW: | 525.59 D |
ab 168,00 €
I-CBP112
Artikelnummer: TGM-T3969-100mg
Description: I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains. Target: Histone Acetyltransferase, Epigenetic Reader Domain. Smiles: CCC(=O)N1CCOc2c(C1)cc(cc2OC[C@H]1CCCN(C)C1)-c1ccc(OC)c(OC)c1. References: Zucconi BE, et al....
| Anwendung: | P300 / CBP inhibitor |
| CAS | 1640282-31-0 |
| MW: | 468.59 D |
ab 30,00 €
I-CBP112 hydrochloride
Artikelnummer: TGM-T4247-100mg
Description: I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells...
| Anwendung: | CBP and EP300 inhibitor |
| CAS | 2147701-33-3 |
| MW: | 505.05 D |
ab 83,00 €
JQAD1
Artikelnummer: TGM-T41180-100mg
Description: JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC(R), DC50= 31.6 nM), comprises an EP300 inhibitor, A485, joined by a linker to a cereblon E3 ligase ligand. JQAD1 brings about degradation of EP300 in neuroblastoma cell lines in a proteasome-dependent manner. JQAD1...
| Anwendung: | PROTAC, p300 degradation |
| CAS | 2417097-18-6 |
| MW: | 932.95 D |
ab 134,00 €
Pocenbrodib
Artikelnummer: TGM-T69691-100mg
Description: Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research. Target: Epigenetic Reader Domain. Smiles: [C@H](O)(C1=NC2=C(N1[C@H]3C[C@H](C(O)=O)CCC3)C=CC4=C2CC[C@H](C)N4C(OC)=O)C5=C(OC)C=CC(F)=C5....
| Schlagworte: | P-300, FT-7051 |
| Anwendung: | Targets E1A/CREB-binding protein [EC:2.3.1.48] (EP300, CREBBP, KAT3) |
| CAS | 2304372-79-8 |
| MW: | 525.57 D |
ab 805,00 €