Zu "K04456" wurden 616 Artikel gefunden!
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3CAI
Artikelnummer: TGM-T14034-100mg
Description: 3CAI is a potent and specific AKT1 and AKT2 inhibitor, demonstrating significant inhibition of AKT in an in vitro kinase assay. It suppressed the expression of AKT direct downstream targets (such as mTOR and GSK3beta) and induced growth inhibition and apoptosis in colon cancer cells. Target: Akt....
| Anwendung: | Akt1 / Akt2 inhibitor |
| CAS | 28755-03-5 |
| MW: | 193.63 D |
ab 50,00 €
A-443654
Artikelnummer: TGM-T14072-100mg
Description: A-443654, a pan-Akt inhibitor, exhibits equal potency against Akt1, Akt2, and Akt3 within cells (Ki=160 pM). Target: MAPK, Casein Kinase, PKC, Src, Akt, FLT, Chk, GSK-3, CDK, ERK, VEGFR, PKA, S6 Kinase. Smiles: C([C@@H](COC=1C=C(C=NC1)C=2C=C3C(=CC2)NN=C3C)N)C=4C=5C(NC4)=CC=CC5. References:...
| Anwendung: | Potent and selective Akt inhibitor |
| CAS | 552325-16-3 |
| MW: | 397.47 D |
ab 82,00 €
AKT-I-1
Artikelnummer: TGM-T25017-100mg
Description: AKT-I-1 is a selective and reversible inhibitor of Akt1. Target: Akt. Smiles: CN(C)CC(C)(C)CNc1nn2c(nnc2cc1C1CCC1)-c1ccccc1. References: Zhang Q, et al. Autophagy prevention sensitizes AKTi-1/2-induced anti-hepatocellular carcinoma cell activity in vitro and in vivo. Biochem Biophys Res Commun. 2016 Nov...
| Anwendung: | Akt1 inhibitor |
| CAS | 473382-39-7 |
| MW: | 378.51 D |
ab 228,00 €
10-DEBC hydrochloride
Artikelnummer: TGM-T21778-1mg
Description: 10-DEBC hydrochloride, a selective Akt inhibitor demonstrating an IC50 value of 1.28 µM, is identified as a novel anti-tuberculosis compound [1] [2]. Target: Others. Smiles: Cl.ClC1=CC=C2OC=3C=CC=CC3N(C2=C1)CCCCN(CC)CC
| Anwendung: | Akt phosphorylation inhibitor |
| CAS | 925681-41-0 |
| MW: | 381.34 D |
ab 120,00 €
Miransertib
Artikelnummer: TGM-T3467-100mg
Description: Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor. Target: Akt, Parasite. Smiles: Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1ccccc1. References: Yu Y, et al. PLoS One. 2015, 10(10):e20140479.
| Schlagworte: | AKT inhibitor 2, ARQ-092 |
| Anwendung: | Targets RAC serine/threonine-protein kinase [EC:2.7.11.1] (AKT) |
| CAS | 1313881-70-7 |
| MW: | 432.52 D |
ab 44,00 €
SC66
Artikelnummer: TGM-T3132-10mg
Description: SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 µg/ml, at 72 h). Target: Apoptosis, Akt. Smiles: O=C1\C(CCC\C1=C/c1ccncc1)=C\c1ccncc1. References: Cusimano A, et al. Oncotarget. 2015 Jan 30,6(3):1707-22.
| Anwendung: | AKT inhibitor |
| CAS | 871361-88-5 |
| MW: | 276.33 D |
ab 40,00 €
AKT inhibitor VIII
Artikelnummer: TGM-T3346-100mg
Description: AKT inhibitor VIII (AKTi-1/2) is a highly specific inhibitor of Akt1/2, with IC50 values of 58 nM and 210 nM respectively, demonstrating approximately 36-fold greater selectivity for Akt1 over Akt3. Target: Apoptosis, Akt. Smiles: O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4[nH]cnc4cc3nc2-c2ccccc2)CC1....
| Schlagworte: | AKTi-1/2 |
| Anwendung: | Akt1/Akt2 inhibitor |
| CAS | 612847-09-3 |
| MW: | 551.64 D |
ab 44,00 €
CAY10567
Artikelnummer: TGM-T36086-100mg
Description: CAY10567 has a wide range of applications in life science related research. Target: Others. Smiles: OC(=O)C1=CC=C2N=C(C3=CC=CC=C3)C(=NC2=C1)C1=CC=CC=C1
| Anwendung: | Akt1 translocation inhibitor |
| CAS | 32387-96-5 |
| MW: | 326.35 D |
ab 67,00 €
Isobavachalcone
Artikelnummer: TGM-T3861-100mg
Description: Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation. Target: Autophagy, Apoptosis, Akt, Reactive Oxygen Species, Others. Smiles:...
| Schlagworte: | Corylifolinin, Isobacachalcone |
| Anwendung: | Akt1 inibitor |
| CAS | 20784-50-3 |
| MW: | 324.37 D |
ab 54,00 €
AKT-IN-1
Artikelnummer: TGM-T4489-100mg
Description: AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 µM). Target: Akt. Smiles: NC(=O)c1cnc(-c2ccc(cc2)C2(N)CCC2)c(c1)-c1ccccc1. References: Kettle JG, et al. Diverse heterocyclic scaffolds as allosteric inhibitors of AKT. J Med Chem. 2012 Feb 9,55(3):1261-73.
| Schlagworte: | AZD26, AZD-26, AZD 26 |
| Anwendung: | AKT inhibitor |
| CAS | 1357158-81-6 |
| MW: | 343.42 D |
ab 112,00 €
BAY1125976
Artikelnummer: TGM-T7315-100mg
Description: BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay). Target: Akt. Smiles: NC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1. References: Politz O , Siegel F , Bärfacker L, et al. BAY 1125976, a selective allosteric AKT1/2...
| Anwendung: | Allosteric Akt1/2 inhibitor |
| CAS | 1402608-02-9 |
| MW: | 383.45 D |
ab 33,00 €
Borussertib
Artikelnummer: TGM-T8427-100mg
Description: Borussertib is a first-in-class covalent-allosteric inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. Target: Akt. Smiles: C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(Cc4ccc(cc4)-c4nc5cc[nH]c(=O)c5cc4-c4ccccc4)CC3)c2c1. References: Niklas Uhlenbrock, et al. Structural and...
| Anwendung: | Akt1 / Akt2 inhibitor |
| CAS | 1800070-77-2 |
| MW: | 596.68 D |
ab 132,00 €