Zu "K04451" wurden 650 Artikel gefunden!
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SAR405838
Artikelnummer: TGM-T6585-100mg
Description: MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1. Target: E1/E2/E3 Enzyme, Mdm2. Smiles: CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1. References: Wang S, et al. Cancer Res. 2014, 74(20), 5855-5865.
| Schlagworte: | MI-77301, MI-773, MI773, MI 773 |
| Anwendung: | MDM2-p53 interaction inhibitor |
| CAS | 1303607-60-4 |
| MW: | 562.5 D |
ab 45,00 €
YH239-EE
Artikelnummer: TGM-T6149-100mg
Description: YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer. Target: Apoptosis, E1/E2/E3 Enzyme. Smiles: CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(N(Cc1ccc(Cl)cc1)C=O)C(=O)NC(C)(C)C. References: Huang Y, et al. ACS Chem Biol. 2014, 9(3), 802-811.
| Anwendung: | YH 239 prodrug, p53-MDM2 protein-protein interaction inhibitor |
| CAS | 1364488-67-4 |
| MW: | 504.41 D |
ab 59,00 €
NSC 146109 hydrochloride
Artikelnummer: TGM-T12257-10mg
Description: NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer. Target: Others, Apoptosis. Smiles: Cl.Cc1c2ccccc2c(CSC(N)=N)c2ccccc12. References: Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX...
| Anwendung: | p53 activator |
| CAS | 59474-01-0 |
| MW: | 316.85 D |
ab 34,00 €
Pifithrin-alpha, p-Nitro, Cyclic
Artikelnummer: TGM-T12472-100mg
Description: Pifithrin-alpha, p-Nitro, Cyclic (PFN-alpha) is a cell-permeable, active-form inhibitor of p53. Target: p53. Smiles: [O-][N+](=O)C1=CC=C(C=C1)C1=CN2C(SC3=C2CCCC3)=N1. References: Pietrancosta N, et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo...
| Schlagworte: | PFN-alpha |
| Anwendung: | Cell-permeable p53 inhibitor |
| CAS | 60477-38-5 |
| MW: | 299.35 D |
ab 34,00 €
CP-31398 dihydrochloride
Artikelnummer: TGM-T21648-100mg
Description: CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Target: p53. Smiles: Cl.Cl.COc1ccc(\C=C\c2nc(NCCCN(C)C)c3ccccc3n2)cc1. References: Rishu Takimoto, et al. The Mutant p53-Conformation...
| Schlagworte: | CP 31398 dihydrochloride |
| Anwendung: | p53 stabilizing agent |
| CAS | 1217195-61-3 |
| MW: | 435.4 D |
ab 32,00 €
Roslin 2 bromide
Artikelnummer: TGM-T24730-100mg
Description: Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5, exhibiting anticancer effects. Target: FAK, p53. Smiles: [Br-].C(c1ccccc1)[N+]12CN3CN(CN(C3)C1)C2. References: Learmount J, Callaby R, Taylor M. An observational study of ewe treatments...
| Schlagworte: | Roslin-2, Roslin2, Benzylhexamethylenetetramine bromide |
| Anwendung: | p53 reactivator, FAK-p53 interaction inhibitor |
| CAS | 29574-21-8 |
| MW: | 311.22 D |
ab 44,00 €
RO8994
Artikelnummer: TGM-T3517-100mg
Description: RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays). Target: p53, E1/E2/E3 Enzyme, Mdm2. Smiles:...
| Anwendung: | MDM2-p53 protein-protein interaction inhibitor |
| CAS | 1309684-94-3 |
| MW: | 613.51 D |
ab 34,00 €
Pifithrin-alpha hydrobromide
Artikelnummer: TGM-T2707-100mg
Description: Pifithrin-alpha hydrobromide (Pifithrin-alpha hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes. Target: Aryl Hydrocarbon Receptor, p53, Ferroptosis. Smiles: Br.Cc1ccc(cc1)C(=O)Cn1c2CCCCc2sc1=N. References: Komarov PG, et al. Science, 1999, 285(5434),...
| Schlagworte: | Pifithrin hydrobromide, Pifithrin-alpha (PFTalpha) HBr, Pifithrin-alpha, PFTalpha, PFTalpha hydrobromide |
| Anwendung: | p53 inhibitor |
| CAS | 63208-82-2 |
| MW: | 367.3 D |
ab 33,00 €
CAY10682
Artikelnummer: TGM-T36192-10mg
Description: (±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 is a pyrrolo[3,4c]pyrazole derivative that inhibits the p53-Mdm2 interaction as potently as...
| Anwendung: | p53-Mdm2 interaction inhibitor |
| CAS | 1542066-74-9 |
| MW: | 570.45 D |
ab 286,00 €
Pifithrin-beta hydrobromide
Artikelnummer: TGM-T3637-100mg
Description: Pifithrin-beta hydrobromide (Cyclic PFT-alpha) is an inhibitor of p53, reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo, protects mice from the side-effects of Y therapy...
| Schlagworte: | PFT beta (hydrobromide), Cyclic PFT-alpha, Cyclic Pifithrin-alpha hydrobromide, Pifithrin-beta, Cyclic Pifithrin-alpha... |
| Anwendung: | PFT-alpha analog, p53-dependent transcription / apoptosis inhibitor |
| CAS | 511296-88-1 |
| MW: | 349.29 D |
ab 34,00 €
Kevetrin hydrochloride
Artikelnummer: TGM-T3184-100mg
Description: Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target: p53, Mdm2. Smiles: Cl.NC(=N)SCCCC#N. References: Han D., Smalley K. (2015) Targeting the Cell Cycle and p53 in...
| Schlagworte: | 4-Isothioureidobutyronitrile hydrochloride, thioureido butyronitrile hydrochloride, Thioureidobutyronitrile HCl |
| Anwendung: | p53 activator |
| CAS | 66592-89-0 |
| MW: | 179.67 D |
ab 38,00 €
SCH529074
Artikelnummer: TGM-T37042-100mg
Description: SCH529074 is a selective activator of p53 (Ki = 1 µM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. Target: p53. Smiles: CN(C)CCCNc1nc(CN2CCN(CC2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)nc2ccccc12....
| Schlagworte: | SCH 529074 |
| Anwendung: | p53 activator |
| CAS | 922150-11-6 |
| MW: | 563.56 D |
ab 31,00 €