Zu "K04447" wurden 217 Artikel gefunden!
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NEU
JAK2 JH2 Domain (human, recombinant, aa 513-827) -...
Artikelnummer: Cay42273-10
JAK2 is a non-receptor tyrosine kinase that has roles in immune signaling. It is composed of N-terminal FERM and SH2 domains, a regulatory JH2 pseudokinase domain, and a C-terminal JH1 kinase domain. It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane. Activation...
| Schlagworte: | JAK-2, JAK-2, Janus kinase 2, Janus kinase 2, Tyrosine-protein kinase JAK2 {ECO:0000305}, Tyrosine-protein kinase JAK2... |
| Anwendung: | Active enzyme |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
512,00 €
TG-89
Artikelnummer: TGM-T20742-100mg
Description: TG-89 is an inhibitor of JAK2, JAK3, RET and FLT3, and has an IC50 value of 11.2 µM against JAK2, showing anticancer activity in the treatment of ovarian and cervical cancer. Target: JAK, FLT, c-RET. Smiles: Cc1cnc(Nc2cccc(CN3CCOCC3)c2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C. References: FURUKAWA Y, et al....
| Anwendung: | JAK2 inhibitor |
| CAS | 936091-56-4 |
| MW: | 510.65 D |
ab 55,00 €
TG-46
Artikelnummer: TGM-T20743-100mg
Description: TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma. Target: JAK, FLT. Smiles: Cc1cnc(Nc2ccc(CN3CCOCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C. References: Pinto NA, et al. Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs. Cell Death Differ....
| Schlagworte: | TG46, TG 46 |
| Anwendung: | JAK2 inhibitor |
| CAS | 936091-15-5 |
| MW: | 510.65 D |
ab 190,00 €
SD-1029
Artikelnummer: TGM-T24774-1mg
Description: SD-1029 is a cell-permeable JAK2 inhibitor. Target: Others. Smiles: O=C1C2=C(CCC1CN(C)C)OC3=C(C2C4=CC=C(C(Cl)=C4)Cl)C(C(CC3)CN(C)C)=O.Br.Br. References: Zelano J, Larsson D, Kumlien E, Åsberg S. Pre-stroke seizures: A nationwide register-based investigation. Seizure. 2017 Jul,49:25-29. doi:...
| Schlagworte: | NSC 371488, NSC-371488, SD 1029, NSC371488 |
| Anwendung: | JAK2 inhibitor |
| CAS | 118372-34-2 |
| MW: | 639.25 D |
ab 77,00 €
Pyridone 6
Artikelnummer: TGM-T3080-100mg
Description: Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM), displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases. Target: JAK, Tyrosine Kinases. Smiles:...
| Schlagworte: | CMP 6, JAK Inhibitor, JAK Inhibitor I, Janus-Associated Kinase Inhibitor I |
| Anwendung: | JAK2, JAK3, JAK1 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309.34 D |
ab 74,00 €
JAK2 Inhibitor V
Artikelnummer: TGM-T3042-100mg
Description: JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner. Target: JAK. Smiles: CC(CCc1ccccn1)(CCc1ccccn1)C(=O)c1ccccc1. References: Jacqueline Sayyah, et al. Mol Y Ther 2008,7(8):2308-18.
| Schlagworte: | JAK2 Inhibitor V Z3, Z3, NSC42834 |
| Anwendung: | JAK2 inhibitor |
| CAS | 195371-52-9 |
| MW: | 344.45 D |
ab 33,00 €
Ruxolitinib phosphate
Artikelnummer: TGM-T3043-100mg
Description: Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Target: Autophagy, Mitophagy, JAK. Smiles: OP(O)(O)=O.N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12....
| Schlagworte: | INCB018424, INC 424 phosphate, INC424, INCB018424 phosphate, Ruxolitinib (INCB-18424) phosphate |
| Anwendung: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1092939-17-7 |
| MW: | 404.36 D |
ab 44,00 €
Peficitinib hydrobromide
Artikelnummer: TGM-T33905-100mg
Description: Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis. Target: Others. Smiles: Br.[H][C@]12CC3C[C@]([H])(CC(O)(C3)C1)[C@H]2Nc1c(cnc2[nH]ccc12)C(N)=O. References: D'Amico F, Fiorino G, Furfaro F, Allocca M, Danese S. Janus kinase inhibitors for the treatment of...
| Anwendung: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1353219-05-2 |
| MW: | 407.312 D |
ab 1.638,00 €
TG101209
Artikelnummer: TGM-T3065-100mg
Description: TG101209 is a selective JAK2 inhibitor with an IC50 of 6 nM. Target: Autophagy, FLT, Apoptosis, c-RET, JAK. Smiles: CN1CCN(CC1)c1ccc(Nc2ncc(C)c(Nc3cccc(c3)S(=O)(=O)NC(C)(C)C)n2)cc1. References: Pardanani A, et al, Leukemia, 2007, 21(8), 1658-1668.
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 936091-14-4 |
| MW: | 509.67 D |
ab 40,00 €
AT9283
Artikelnummer: TGM-T3068-100mg
Description: AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I). Target: JAK, FLT, Autophagy, Aurora Kinase, Apoptosis, Bcr-Abl. Smiles: O=C(NC1CC1)Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1. References: Howard S, et al. J Med...
| Schlagworte: | J-504568 |
| Anwendung: | Broad spectrum kinase inhibitor |
| CAS | 896466-04-9 |
| MW: | 381.43 D |
ab 39,00 €
AZD-1480
Artikelnummer: TGM-T3069-10mg
Description: AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential...
| Anwendung: | JAK2 inhibitor |
| CAS | 935666-88-9 |
| MW: | 348.77 D |
ab 52,00 €
XL019
Artikelnummer: TGM-T3072-100mg
Description: XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1. Target: Apoptosis, FLT, PDGFR, JAK. Smiles: O=C(Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1)[C@@H]1CCCN1. References: Forsyth T, et al. Bioorg Med Chem Lett, 2012, 22(24), 7653-7658.
| Anwendung: | JAK2 inhibitor |
| CAS | 945755-56-6 |
| MW: | 444.53 D |
ab 67,00 €