Zu "K04437" wurden 102 Artikel gefunden!
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Simufilam
Artikelnummer: LKT-S336505.1
Simufilam was first introduced as having the potential to reduce biomarkers of Alzheimer's disease. The original data has since become suspect and could not be found. Fraud charges have been filed by the SEC. Simufilam may or may not have some useful bioactivities. The proper research, with proper data collection...
| Schlagworte: | PTI-125, PTI-910, C0105, 1,4,8-Triazaspiro(4.5)decan-2-one, 8-methyl-1-(phenylmethyl)-,... |
| Anwendung: | Unlikely to reverse Alzheimer's |
| CAS | 1224591-33-6 |
| MW: | 259.35 D |
ab 143,00 €
Simufilam Dihydrochloride
Artikelnummer: LKT-S336507.100
Simufilam was first introduced as having the potential to reduce biomarkers of Alzheimer's disease. The original data has since become suspect and could not be found. Fraud charges have been filed by the SEC. Simufilam may or may not have some useful bioactivities. The proper research, with proper data collection...
| Schlagworte: | PTI-125 dihydrochloride, PTI diHCl, JP8XRG9A58, 4-benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-3-one,dihydrochloride |
| Anwendung: | Unlikely to reverse Alzheimer's |
| CAS | 2480226-06-8 |
| MW: | 332.3 D |
ab 229,00 €
Anti-FLNA
Artikelnummer: ABS-KC-2561.100
Protein function: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration...
| Schlagworte: | Anti-Filamin-A, Anti-FLN-A, Anti-Actin-binding protein 280, Anti-ABP-280, Anti-Alpha-filamin, Anti-Endothelial... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-FLNA
Artikelnummer: ABS-KC-3174.100
Protein function: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration...
| Schlagworte: | Anti-Filamin-A, Anti-FLN-A, Anti-Actin-binding protein 280, Anti-ABP-280, Anti-Alpha-filamin, Anti-Endothelial... |
| Anwendung: | IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-FLNA
Artikelnummer: ABS-OC-255.100
Protein function: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration...
| Schlagworte: | Anti-Filamin-A, Anti-FLN-A, Anti-Actin-binding protein 280, Anti-ABP-280, Anti-Alpha-filamin, Anti-Endothelial... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
PTI-125 (hydrochloride)
Artikelnummer: Cay41859-10
PTI-125 is a purported binding agent of filamin A, a cytoskeletal protein said to stabilize the interaction between amyloid-beta (1-42) (Abeta42) and the alpha7 nicotinic acetylcholine receptor (nAChR). PTI-125 reportedly binds to filamin A to reverse an aberrant conformational change induced by Abeta42, which...
| Schlagworte: | 8-methyl-1-(phenylmethyl)-1,4,8-triazaspiro[4.5]decan-2-one, monohydrochloride |
| Anwendung: | Purported Filamin A binding agent |
| CAS | 2480226-06-8 |
| MW: | 332.3 D |
ab 226,00 €
simufilamum
Artikelnummer: TGM-T9569-100mg
Description: Simufilam (PTI-125) is a low toxicity, orally active filamin A ( FLNA ) activator. Simufilam preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam can be used in...
| Anwendung: | Targets filamin-A (FLNA) |
| CAS | 1224591-33-6 |
| MW: | 259.35 D |
ab 1.149,00 €
Filamin-A Protein, Human, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-01342-100ug
Description: Filamin-A Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.0 kDa and the accession number is P21333.
| Schlagworte: | Filamin-1, FLNA, Alpha-filamin, Actin-binding protein 280, Endothelial actin-binding protein, Filamin-A, Non-muscle filamin |
| MW: | 38.0 kD |
ab 281,00 €
Kartogenin
Artikelnummer: TGM-T1748-100mg
Description: Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. Target: TGF-beta/Smad. Smiles: OC(=O)c1ccccc1C(=O)Nc1ccc(cc1)-c1ccccc1. References: Johnson K, et al. Science. 2012, 336(6082), 717-721.
| Schlagworte: | KGN |
| Anwendung: | Chondrogenesis inducer |
| CAS | 4727-31-5 |
| MW: | 317.34 D |
ab 31,00 €
Filamin-A (FLNA), partial, human, recombinant
Artikelnummer: CSB-EP008724HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 2-274aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: SSSHSRAGQS AAGAAPGGGV DTRDAEMPAT EKDLAEDAPW KKIQQNTFTR WCNEHLKCVS KRIANLQTDL SDGLRLIALL EVLSQKKMHR KHNQRPTFRQ MQLENVSVAL...
| Schlagworte: | FLN, FLNA, FLN-A, ABP-280, Filamin-A, Filamin-1, Alpha-filamin, Non-muscle filamin, Actin-binding protein 280, Endothelial... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 38.0 kD |
ab 292,00 €
Anti-FLNA
Artikelnummer: CSB-PA002535.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-FLN, Anti-FLNA, Anti-FLN-A, Anti-ABP-280, Anti-Filamin-A, Anti-Filamin-1, Anti-Alpha-filamin, Anti-Non-muscle... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-Phospho-FLNA (S2152)
Artikelnummer: CSB-PA000688.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-phospho-FLN, Anti-phospho-FLNA, Anti-phospho-FLN-A, Anti-phospho-ABP-280, Anti-phospho-Filamin-A,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat, monkey |
ab 126,00 €