Zu "K04371" wurden 340 Artikel gefunden!
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Anti-MAPK3
Artikelnummer: ABS-KC-4086.100
Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF....
| Schlagworte: | Anti-Mitogen-activated protein kinase 3, Anti-MAP kinase 3, Anti-MAPK 3, Anti-ERT2, Anti-Extracellular signal-regulated... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, rat, mouse |
ab 206,00 €
Anti-MAPK3
Artikelnummer: ABS-KC-4213.100
Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF....
| Schlagworte: | Anti-Mitogen-activated protein kinase 3, Anti-MAP kinase 3, Anti-MAPK 3, Anti-ERT2, Anti-Extracellular signal-regulated... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, rat, mouse |
ab 206,00 €
Anti-MAPK3
Artikelnummer: ABS-KC-4219.100
Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF....
| Schlagworte: | Anti-Mitogen-activated protein kinase 3, Anti-MAP kinase 3, Anti-MAPK 3, Anti-ERT2, Anti-Extracellular signal-regulated... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, rat, mouse |
ab 206,00 €
Anti-ERK 1/2
Artikelnummer: E-D-AB-10257L.100
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases,also known as extracellular signal-regulated kinases (ERKs),act in a signaling cascade that regulates various cellular processes such as proliferation,differentiation,and cell cycle progression in response to a variety of...
| Schlagworte: | Anti-ERT2, Anti-MNK1, Anti-Erk1, Anti-Mapk3, Anti-ERK-1, Anti-MAPK 3, Anti-p44-MAPK, Anti-p44-ERK1, EC=2.7.11.24, Anti-MAP... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
ab 109,00 €
SCH 772984
Artikelnummer: Cay19166-1
The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens. SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively). It is highly selective, with only seven kinases of 300 tested showing more than 50%...
| Schlagworte: | (3R)-1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxa... |
| Anwendung: | Potent ERK1 / ERK2 inhibitor |
| CAS | 942183-80-4 |
| MW: | 587.7 D |
ab 52,00 €
SCH772984
Artikelnummer: TGM-T6066-2mg
Description: SCH772984 is an ERK inhibitor that inhibits ERK1 and ERK2 (IC50=4/1 nM) and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity against BRAF or RAS mutant cells. Target: MEK, ERK. Smiles: O=C(CN1CC[C@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1....
| Anwendung: | Potent ERK1 / ERK2 inhibitor |
| CAS | 942183-80-4 |
| MW: | 587.67 D |
ab 48,00 €
CAY10561
Artikelnummer: TGM-T36672-10mg
Description: The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary....
| Anwendung: | ERK2 inhibitor |
| CAS | 933786-58-4 |
| MW: | 459.3 D |
ab 65,00 €
ERK-IN-4
Artikelnummer: TGM-T36675-100mg
Description: ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction. Target: ERK. Smiles: Cl.O=C1SC(=CC2=CC=C(OCC)C=C2)C(=O)N1CCN. References: Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase...
| Schlagworte: | ERK Inhibitor |
| Anwendung: | MAPK1 / MAPK3 inhibitor |
| CAS | 1049738-54-6 |
| MW: | 328.814 D |
ab 42,00 €
ADTL-EI1712
Artikelnummer: TGM-T38377-10mg
Description: ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively).1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 µM. ADTL-EI1712 inhibits proliferation of HL-60 and MKN74, but not...
| Schlagworte: | ADTL-EI1712 |
| Anwendung: | Dual ERK1 / ERK5 inhibitor |
| CAS | 2414916-45-1 |
| MW: | 505.44 D |
ab 154,00 €
Temuterkib
Artikelnummer: TGM-T4091-100mg
Description: Temuterkib (LY3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Target: ERK. Smiles: Cn1nccc1Nc1nccc(n1)-c1cc2C(=O)N(CCN3CCOCC3)C(C)(C)c2s1. References: Shripad V. Bhagwat, et al. Abstract...
| Schlagworte: | LY3214996 |
| Anwendung: | Targets mitogen-activated protein kinase 1/3 [EC:2.7.11.24] (ERK, MAPK1_3) |
| CAS | 1951483-29-6 |
| MW: | 453.56 D |
ab 63,00 €
AG126
Artikelnummer: TGM-T4092-100mg
Description: AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 µM. It blocks the production of TNF-alpha in vitro2 and in vivo, attenuating signaling through NF-kappaB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal...
| Schlagworte: | AG 126, Tyrphostin AG126 |
| Anwendung: | ERK inhibitor |
| CAS | 118409-62-4 |
| MW: | 215.16 D |
ab 31,00 €
Ulixertinib
Artikelnummer: TGM-T7005-100mg
Description: Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2. Target: ERK. Smiles: CC(C)Nc1cc(-c2c[nH]c(c2)C(=O)N[C@H](CO)c2cccc(Cl)c2)c(Cl)cn1. References: Ward RA, et al. J Med Chem. 2015, 58(11), 4790-4801.
| Schlagworte: | VRT752271, BVD-523 |
| Anwendung: | Targets mitogen-activated protein kinase 1/3 [EC:2.7.11.24] (ERK, MAPK1_3) |
| CAS | 869886-67-9 |
| MW: | 433.33 D |
ab 34,00 €