Zu "K04369" wurden 137 Artikel gefunden!
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PD 0325901
Artikelnummer: Cay13034-25
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation...
| Schlagworte: | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Anwendung: | MEK inhibitor |
| CAS | 391210-10-9 |
| MW: | 482.2 D |
ab 59,00 €
GSK1120212
Artikelnummer: LKT-G7440.5
GSK1120212 inhibits MEK1/2 and is currently in clinical trials as a potential treatment for melanoma. GSK1120212 exhibits anticancer chemotherapeutic activity, upregulating p27 expression and inhibiting growth in colorectal cancer cells and suppressing tumor growth in colorectal cancer xenografts.
| Schlagworte: | Trametinib, JTP-74057 |
| Anwendung: | MEK1/2 inhibitor |
| CAS | 871700-17-3 |
| MW: | 615.39 D |
ab 109,00 €
MEK2 Protein, Human, Recombinant (GST)
Artikelnummer: TGM-TMPY-04544-50ug
Description: Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains...
| Schlagworte: | MEK2, PRKMK2, CFC4, MAPKK2, mitogen-activated protein kinase kinase 2, FLJ26075, MKK2 |
| MW: | 70.7 kD |
397,00 €
AZD8330
Artikelnummer: TGM-T6083-10mg
Description: AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. Target: ERK, MEK. Smiles: Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)n(C)c1=O. References: Wallace EM, et al. AACR Annual Meeting, 2009, Abst 3696.
| Schlagworte: | ARRY-704, ARRY-424704 |
| Anwendung: | MEK inhibitor |
| CAS | 869357-68-6 |
| MW: | 461.23 D |
ab 33,00 €
U-0126
Artikelnummer: Cay70970-5
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively. It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3,...
| Schlagworte: | 2,3-bis[amino[(2-aminophenyl)thio]methylene]-butanedinitrile |
| Anwendung: | MEK inhibitor |
| CAS | 109511-58-2 |
| MW: | 380.5 D |
ab 61,00 €
Anti-MAP2K2 Monoclonal
Artikelnummer: CSB-MA671424.100
Host Species: Mouse. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen....
| Schlagworte: | Anti-MEK2, Anti-MEK 2, Anti-MAP2K2, Anti-MAPKK 2, Anti-MAPK/ERK kinase 2, Anti-MAP kinase kinase 2, Anti-ERK activator... |
| Anwendung: | ELISA, WB, IHC, IF, IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-Phospho-MAP2K2 (T394)
Artikelnummer: CSB-PA000570.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-phospho-MEK2, Anti-phospho-MEK 2, Anti-phospho-MAP2K2, Anti-phospho-MAPKK 2, Anti-phospho-MAPK/ERK kinase 2,... |
| Anwendung: | ELISA, WB, IHC, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-MAP2K2
Artikelnummer: CSB-PA030302.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-MEK2, Anti-MEK 2, Anti-MAP2K2, Anti-MAPKK 2, Anti-MAPK/ERK kinase 2, Anti-MAP kinase kinase 2, Anti-ERK activator... |
| Anwendung: | ELISA, WB, IHC, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-MAP2K2
Artikelnummer: CSB-PA04909A0Rb.100
Host Species: Rabbit. Isotype: IgG. Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: >95%, Protein G purified. Target Name: MAP2K2. Antigen Species: Human
| Schlagworte: | Anti-MEK2, Anti-MEK 2, Anti-MAP2K2, Anti-MAPKK 2, Anti-MAPK/ERK kinase 2, Anti-MAP kinase kinase 2, Anti-ERK activator... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Anti-Phospho-MAP2K2 (Thr394)
Artikelnummer: CSB-PA062510.100
Host Species: Rabbit. Isotype: IgG. Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits...
| Schlagworte: | Anti-phospho-MEK2, Anti-phospho-MEK 2, Anti-phospho-MAP2K2, Anti-phospho-MAPKK 2, Anti-phospho-MAPK/ERK kinase 2,... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
340,00 €
Anti-MAP2K2
Artikelnummer: CSB-PA080229.100
Host Species: Rabbit. Isotype: IgG. Buffer: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Affinity purification. Target Name: MAP2K2. Antigen Species: Human
| Schlagworte: | Anti-MEK2, Anti-MEK 2, Anti-MAP2K2, Anti-MAPKK 2, Anti-MAPK/ERK kinase 2, Anti-MAP kinase kinase 2, Anti-ERK activator... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-MAP2K2
Artikelnummer: CSB-PA097880.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: MAP2K2. Antigen Species: Human
| Schlagworte: | Anti-MEK2, Anti-MEK 2, Anti-MAP2K2, Anti-MAPKK 2, Anti-MAPK/ERK kinase 2, Anti-MAP kinase kinase 2, Anti-ERK activator... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €