Zu "K04368" wurden 247 Artikel gefunden!
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Trametinib
Artikelnummer: Cay16292-25
Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively). Trametinib inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM)...
| Schlagworte: | GSK1120212, JTP-74057,... |
| Anwendung: | MEK1 / MEK2 inhibitor |
| CAS | 871700-17-3 |
| MW: | 615.4 D |
ab 94,00 €
Cobimetinib
Artikelnummer: TGM-T3623-100mg
Description: Cobimetinib (GDC-0973) is a MEK1 inhibitor (IC50=4.2 nM) with selective and oral activity. Cobimetinib exhibits antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis. Target: Apoptosis, MEK. Smiles: C(=O)(C1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1)N3C[C@](O)(C3)[C@@H]4CCCCN4....
| Schlagworte: | RG7420, GDC-0973, XL518 |
| Anwendung: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 934660-93-2 |
| MW: | 531.31 D |
ab 34,00 €
U0126
Artikelnummer: TGM-T21332-1mg
Description: U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 µM respectively. U0126 inhibits autophagy and mitophagy. Target: Autophagy, MEK, Mitophagy. Smiles: N#CC(=C(SC=1C=CC=CC1N)N)C(C#N)=C(SC=2C=CC=CC2N)N. References:...
| Schlagworte: | U-0126, U 0126 |
| Anwendung: | MEK inhibitor |
| CAS | 109511-58-2 |
| MW: | 380.49 D |
ab 158,00 €
PD98059
Artikelnummer: TGM-T2623-100mg
Description: PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 µM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy. Target: Aryl Hydrocarbon Receptor, MEK, Autophagy, ERK. Smiles: COc1cccc(c1N)-c1cc(=O)c2ccccc2o1. References: Zhao Y, et al....
| Schlagworte: | PD 98059 |
| Anwendung: | MEK inhibitor |
| CAS | 167869-21-8 |
| MW: | 267.28 D |
ab 34,00 €
SL327
Artikelnummer: TGM-T2708-100mg
Description: SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 µM/0.22 µM, able to transport through the blood-brain barrier. Target: DNA/RNA Synthesis, MEK. Smiles: NC(Sc1ccc(N)cc1)=C(C#N)c1ccccc1C(F)(F)F. References: Scherle PA, wt al. J Biol Chem. 2000, 275(47), 37086-37092.
| Schlagworte: | SL 327, SL-327 |
| Anwendung: | MEK1 / MEK2 inhibitor |
| CAS | 305350-87-2 |
| MW: | 335.35 D |
ab 31,00 €
RO4987655
Artikelnummer: TGM-T5412-100mg
Description: RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2). Target: MEK. Smiles: OCCONC(=O)c1cc(CN2OCCCC2=O)c(F)c(F)c1Nc1ccc(I)cc1F. References: Lee L, et al. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in...
| Schlagworte: | RG7167, CH4987655 |
| Anwendung: | MEK inhibitor |
| CAS | 874101-00-5 |
| MW: | 565.28 D |
ab 72,00 €
Trametinib (DMSO solvate)
Artikelnummer: TGM-T5857-100mg
Description: Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a highly potent and selective MEK inhibitor that specifically inhibits MEK1/2 (IC50: 2 nM). Target: Apoptosis, MEK. Smiles: CS(C)=O.CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O. References: Abe H , Kikuchi S , Hayakawa...
| Schlagworte: | Trametinib DMSO solvate, GSK-1120212 (DMSO solvate), JTP-74057 (DMSO solvate), Trametinib dimethyl sulfoxide |
| Anwendung: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 1187431-43-1 |
| MW: | 693.53 D |
ab 42,00 €
Cobimetinib hemifumarate
Artikelnummer: TGM-T64175-2mg
Description: Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1. Target: Others. Smiles: OC(=O)\C=C\C(O)=O.OC1(CN(C1)C(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)[C@@H]1CCCCN1.OC1(CN(C1)C(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)[C@@H]1CCCCN1
| Anwendung: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 1369665-02-0 |
| MW: | 1178.707 D |
54,00 €
Selumetinib
Artikelnummer: TGM-T6218-100mg
Description: Selumetinib (AZD6244) is a MEK1/2 inhibitor that inhibits MEK1 (IC50=14 nM) with potent selectivity and is non-ATP-competitive. Selumetinib has antitumor activity and is used for the treatment of neurofibromatosis type 1 (NF1). Target: ERK, MEK, Apoptosis. Smiles:...
| Schlagworte: | AZD6244, ARRY-142886 |
| Anwendung: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 606143-52-6 |
| MW: | 457.68 D |
ab 46,00 €
GDC-0623
Artikelnummer: TGM-T6843-100mg
Description: GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1. Target: MEK, Apoptosis. Smiles: OCCONC(=O)c1ccc2cncn2c1Nc1ccc(I)cc1F. References: Hatzivassiliou G, et al. Nature. 2013, 501(7466), 232-236.
| Schlagworte: | MEK inhibitor 1, RG 7421, GDC0623, G-868 |
| Anwendung: | MEK1 inhibitor |
| CAS | 1168091-68-6 |
| MW: | 456.21 D |
ab 48,00 €
Pimasertib HCl
Artikelnummer: TGM-T71163-100mg
Description: Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may...
| Anwendung: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 1236361-78-6 |
| MW: | 467.66 D |
ab 1.520,00 €
Nedometinib
Artikelnummer: TGM-T78209-50mg
Description: Nedometinib, a tyrosine kinase inhibitor, specifically targets MEK1 and exhibits antineoplastic effects. It is utilized in research related to dermatosis, cutaneous fibroneruroma, and neurofibromatosis [1]. Target: MEK. Smiles: O=C(NOCCO)C=1C=2C=CC=NC2N(C1NC3=CC=C(I)C=C3F)C
| Anwendung: | MEK1 inhibitor |
| CAS | 2252314-46-6 |
| MW: | 470.24 D |
ab 161,00 €