Zu "K04362" wurden 213 Artikel gefunden!
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FGFR1, active human recombinant protein
Artikelnummer: BPS-40210
Active recombinant human FGFR1 (399-822) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag. The gene accession number is NM_023110. Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
| Schlagworte: | N-sam, CD331, BFGFR, FLT-2, FGFR1, FGFR-1, bFGF-R-1, Proto-oncogene c-Fgr, Fms-like tyrosine kinase 2, Fibroblast growth... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 73 kD |
862,00 €
NEU
ASP5878
Artikelnummer: Cay41841-1
ASP5878 is an inhibitor of wild-type FGFR1, -2, -3, and -4 (IC50s = 0.47, 0.6, 0.74, and 3.5 nM, respectively) and mutant FGFR3K650E, FGFR3K560M, and FGFR4N535K (IC50s = 1.6, 4.2, and 78 nM, respectively). It is selective for these FGFRs over a panel of 128 additional kinases at 200 nM but does inhibit VEGFR2 and...
| Schlagworte: | 4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]-2-pyrimidinyl]amino]-1H-pyrazole-1-ethanol |
| Anwendung: | Wild-type/mutant FGFR inhibitor |
| CAS | 1453208-66-6 |
| MW: | 407.4 D |
ab 54,00 €
Nintedanib
Artikelnummer: TGM-T1777-50mg
Description: Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRalpha, and PDGFRbeta (IC50=59/65 nM). Nintedanib has antitumor activity and inhibits tumor growth by inhibiting angiogenesis....
| Schlagworte: | BIBF 1120, Intedanib |
| Anwendung: | Targets FMS-like tyrosine kinase 1 [EC:2.7.10.1] (FLT1, VEGFR1) |
| CAS | 656247-17-5 |
| MW: | 539.62 D |
ab 38,00 €
AZD4547
Artikelnummer: TGM-T1948-100mg
Description: AZD4547, a new-type specific FGFR inhibitor, targets for FGFR1/2/3 (IC50: 0.2/2.5/1.8 nM in cell-free assays). Target: VEGFR, FGFR. Smiles: COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1. References: Gavine PR, et al. AZD4547: an orally bioavailable, potent, and selective...
| Anwendung: | FGFR inhibitor |
| CAS | 1035270-39-3 |
| MW: | 463.57 D |
ab 33,00 €
Infigratinib
Artikelnummer: TGM-T1975-100mg
Description: Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and VEGFR2. Target: Apoptosis, FGFR. Smiles: CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1. References: Guagnano V, et al....
| Schlagworte: | BGJ-398, NVP-BGJ398 |
| Anwendung: | Targets fibroblast growth factor receptor 1 [EC:2.7.10.1] (FGFR1, CD331) |
| CAS | 872511-34-7 |
| MW: | 560.48 D |
ab 39,00 €
Lucitanib
Artikelnummer: TGM-T15185-100mg
Description: Lucitanib (E-3810) is a novel and potent inhibitor of VEGFR and FGFR, selectively targeting VEGFR1, VEGFR2, VEGFR3, FGFR1, and FGFR2 with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively. Target: VEGFR, FGFR. Smiles: CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N)CC5)c(OC)cc34)ccc12....
| Schlagworte: | E-3810 |
| Anwendung: | Targets fibroblast growth factor receptor 1 [EC:2.7.10.1] (FGFR1, CD331) |
| CAS | 1058137-23-7 |
| MW: | 443.49 D |
ab 40,00 €
PD-166866
Artikelnummer: TGM-T3492-100mg
Description: PD-166866 is a selective FGFR tyrosine kinase inhibitor. Target: Autophagy, FGFR. Smiles: COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C. References: Risuleo G, et al. J Exp Clin Cancer Res. 2009, 28:151.
| Schlagworte: | PD166866 |
| Anwendung: | FGFR1 inhibitor |
| CAS | 192705-79-6 |
| MW: | 396.44 D |
ab 34,00 €
E7090
Artikelnummer: TGM-T27234-25mg
Description: E-7090 is a fibroblast growth factor receptor inhibitor. E-7090 is a selective inhibitor of the tyrosine kinase activities of FGFR1, -2, and -3. Target: Others. Smiles: CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12. References: Watanabe Miyano S, Yamamoto Y, Kodama K, Miyajima Y,...
| Schlagworte: | E-7090, E 7090 |
| Anwendung: | Targets fibroblast growth factor receptor 1 [EC:2.7.10.1] (FGFR1, CD331) |
| CAS | 1622204-21-0 |
| MW: | 587.67 D |
ab 2.227,00 €
Tinengotinib
Artikelnummer: TGM-T39718-5mg
Description: Tinengotinib, a novel compound, acts as a potent modulator of protein kinases including Aurora kinase and VEGFR kinase. With its unique properties, Tinengotinib holds promise for investigating diseases marked by abnormalities in these kinases, particularly cancer-related conditions (WO2018108079A1)....
| Anwendung: | Targets aurora kinase A [EC:2.7.11.1] (AURKA) |
| CAS | 2230490-29-4 |
| MW: | 394.86 D |
290,00 €
FGFR1 inhibitor-2
Artikelnummer: TGM-T39992-5mg
Description: FGFR1 inhibitor-2 (with an IC50 of 4.55 µM in MDA-MB-231 cells) is a potent inhibitor of FGFR1. It is specifically useful for studying metastatic triple-negative breast cancer. Target: Others. Smiles: Fc1ccc(cc1)C(CCCCNC(=O)Nc1ccc(c(c1)C(F)(F)F)N(=O)=O)c1ccc(F)cc1. References: Ashraf-Uz-Zaman M, et al....
| Schlagworte: | FGFR1 inhibitor-2 |
| Anwendung: | FGFR1 inhibitor |
| CAS | 2410612-08-5 |
| MW: | 507.461 D |
951,00 €
Zoligratinib
Artikelnummer: TGM-T6024-100mg
Description: Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respectively. Target: FGFR. Smiles: Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N. References: Nakanishi Y, et al. Mol Cancer...
| Schlagworte: | FF284, CH5183284, Debio 1347 |
| Anwendung: | FGFR1/2/3 inhibitor |
| CAS | 1265229-25-1 |
| MW: | 356.38 D |
ab 39,00 €
E7090 succinate
Artikelnummer: TGM-T72749-100mg
Description: E7090 succinate is a selective, potent, orally-administered inhibitor of FGFR1, FGFR2, and FGFR3 tyrosine kinase activities, demonstrating IC50 values of 0.71 nM (FGFR1), 0.50 nM (FGFR2), 1.2 nM (FGFR3), and 120 nM (FGFR4). Target: Others. Smiles:...
| Anwendung: | Targets fibroblast growth factor receptor 2 [EC:2.7.10.1] (FGFR2, CD332) |
| CAS | 1879965-80-6 |
| MW: | 764.82 D |
ab 2.227,00 €