Zu "K04298" wurden 48 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Ticagrelor
Artikelnummer: Cay15425-5
Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM, IC50 = 1.8 µM), which is the main receptor responsible for ADP-induced platelet aggregation. It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding. Formulations containing ticagrelor...
| Schlagworte: | AR-C 126532XX, AZD 6140,... |
| Anwendung: | P2Y12 receptor antagonist |
| CAS | 274693-27-5 |
| MW: | 522.6 D |
ab 44,00 €
Farnesyl Pyrophosphate (ammonium salt)
Artikelnummer: Cay63250-1
Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols. It also serves as a donor in post-translational isoprenylation of proteins. FPP has been identified as an antagonist of P2Y12 receptors (IC50 = 45 µM), attenuating platelet...
| Schlagworte: | FPP, P-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl] ester-diphosphoric acid, triammonium salt |
| Anwendung: | P2Y12 receptor antagonist |
| CAS | 116057-57-9 |
| MW: | 433.4 D |
ab 94,00 €
Prasugrel Hydrochloride
Artikelnummer: TGM-T6952-5mg
Description: Prasugrel Hydrochloride (LY 640315 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome. Target: P2Y Receptor. Smiles: Cl.CC(=O)Oc1cc2CN(CCc2s1)C(C(=O)C1CC1)c1ccccc1F. References: Ogawa T, et al. Eur J...
| Schlagworte: | LY 640315 Hydrochloride, Prasugrel HCl, Effient Hydrochloride, LY 640315, PCR 4099 (hydrochloride) |
| Anwendung: | Targets P2Y purinoceptor 12 (P2RY12) |
| CAS | 389574-19-0 |
| MW: | 409.9 D |
ab 40,00 €
2-oxo Clopidogrel
Artikelnummer: TGM-T36222-1mg
Description: 2-oxo Clopidogrel is an intermediary metabolite of clopidogrel . Clopidogrel is a prodrug that is converted to its active metabolite via two sequential oxidative steps. The first step leads to formation of 2-oxo clopidogrel, followed by conversion to the active metabolite, which binds specifically and...
| Anwendung: | P2RY12 irreversible inhibitor prodrug |
| CAS | 109904-27-0 |
| MW: | 337.82 D |
ab 122,00 €
AZD1283
Artikelnummer: TGM-T3536-100mg
Description: AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 µg/kg/min, respectively. The doses induced the increase...
| Anwendung: | P2Y purinoceptor 12, P2Y12 antagonist |
| CAS | 919351-41-0 |
| MW: | 470.54 D |
ab 31,00 €
(±)-Clopidogrel (hydrochloride)
Artikelnummer: TGM-T35431-10mg
Description: Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite...
| Anwendung: | P2Y12 receptor antagonist |
| CAS | 130209-90-4 |
| MW: | 358.28 D |
ab 343,00 €
Regrelor disodium
Artikelnummer: TGM-T34280-100mg
Description: Regrelor disodium (INS 50589) is a P2Y12 receptor antagonist that prevents thrombosis, effectively inhibits vascular smooth muscle cell contraction, curbs cell proliferation, and reduces inflammation. Target: P2Y Receptor. Smiles:...
| Schlagworte: | Regrelor, INS 50589, INS50589, INS-50589, Regrelor sodium |
| Anwendung: | Targets P2Y purinoceptor 12 (P2RY12) |
| CAS | 676251-22-2 |
| MW: | 576.41 D |
ab 194,00 €
Farnesyl Pyrophosphate ammonium salt
Artikelnummer: TGM-T37775-1mg
Description: Farnesyl Pyrophosphate ammonium (Farnesyl diphosphate ammonium) is a metabolic intermediate of the MVA pathway that acts as a newly identified danger signal to trigger acute cell death and induce neuronal loss in stroke. Target: Others. Smiles:...
| Schlagworte: | FPP ammonium, Farnesyl diphosphate ammonium, (E,E)-Farnesyl pyrophosphate ammonium |
| Anwendung: | P2Y12 receptor antagonist |
| CAS | 116057-57-9 |
| MW: | 433.42 D |
ab 170,00 €
cangrelor tetrasodium
Artikelnummer: TGM-T5036-100mg
Description: Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects. Target: P2Y Receptor, GPR. Smiles: [Na+].[Na+].[Na+].[Na+].CSCCNc1nc(SCCC(F)(F)F)nc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)C(Cl)(Cl)P([O-])([O-])=O)[C@@H](O)[C@H]1O....
| Anwendung: | Targets P2Y purinoceptor 12 (P2RY12) |
| CAS | 163706-36-3 |
| MW: | 864.29 D |
ab 40,00 €
Ticlopidine
Artikelnummer: TGM-T4190-100mg
Description: Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. Target: ATPase, Adiponectin receptor. Smiles: Clc1ccccc1CN1CCc2sccc2C1. References: Maffrand, JP (2012). The story of clopidogrel and its predecessor, ticlopidine:...
| Schlagworte: | Ticlid, PCR 5332 |
| Anwendung: | Targets P2Y purinoceptor 12 (P2RY12) |
| CAS | 55142-85-3 |
| MW: | 263.79 D |
ab 33,00 €
Cangrelor free acid
Artikelnummer: TGM-T70335-100mg
Description: Cangrelor is a P2Y12 inhibitor, and was approved in June 2015 as an antiplatelet drug for intravenous application. Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. It is a modified ATP derivative stable to...
| Anwendung: | Targets P2Y purinoceptor 12 (P2RY12) |
| CAS | 163706-06-7 |
| MW: | 776.36 D |
ab 1.671,00 €
Clopidogrel HCl
Artikelnummer: TGM-T71254-100mg
Description: Clopidogrel HCl is the salt form of Clopidogrel (free base), an inhibitor of ADP-induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. Target: Others. Smiles:...
| Anwendung: | Targets P2Y purinoceptor 12 (P2RY12) |
| CAS | 120202-65-5 |
| MW: | 358.28 D |
ab 1.520,00 €