Zu "K04288" wurden 95 Artikel gefunden!
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CS 2100
Artikelnummer: Cay14396-10
CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist. It selectively induces GTPgammaS binding in CHO-K1 cells expressing human or rat S1P1 (EC50s = 4 and 1.5 nM, respectively) over those expressing human or rat S1P3 (EC50s = >20 and 7.4 µM, respectively). CS 2100 (0.1 and 1 mg/kg) transiently reduces...
| Schlagworte: | 1-[[4-ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid |
| Anwendung: | S1P1 agonist |
| CAS | 913827-99-3 |
| MW: | 461.5 D |
ab 136,00 €
RP-001 hydrochloride
Artikelnummer: TGM-T12780L-10mg
Description: RP-001 hydrochloride is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5. Target: Others. Smiles: Cl.N#CC=1C=C(C=CC1OC(C)C)C2=NC(=NO2)C=3C=CC=C4C3CCC4NCCC(=O)O. References: Cahalan SM, et al. Actions of a...
| Anwendung: | Potent S1P1 receptor agonist |
| CAS | 1781880-34-9 |
| MW: | 468.93 D |
ab 91,00 €
S1PR1 modulator 1
Artikelnummer: TGM-T12821-100mg
Description: S1PR1 modulator 1 is a selective inhibitor of S1PR1, with a pIC50 of 7.6. Target: LPL Receptor. Smiles: N(\CCC)=C\1/N(C(=O)\C(=C\C2=CC(C)=C(OC(C)=O)C=C2)\S1)C3=C(C)C=CC=C3. References: Bell M, et al. Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1). ACS Med...
| Anwendung: | S1P1 agonist |
| CAS | 2328109-05-1 |
| MW: | 408.51 D |
ab 58,00 €
VPC 23019
Artikelnummer: TGM-T17237-100mg
Description: VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). Target: S1P Receptor, LPL Receptor. Smiles: CCCCCCCCc1cccc(NC(=O)[C@H](N)COP(O)(O)=O)c1. References: Davis...
| Anwendung: | Competitive S1P1 / S1P3 receptor antagonist |
| CAS | 449173-19-7 |
| MW: | 372.4 D |
ab 650,00 €
Cenerimod
Artikelnummer: TGM-T14924-10mg
Description: Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimmune encephalomyelitis (EAE) and murine scleroderma. Target: S1P Receptor. Smiles:...
| Schlagworte: | ACT-334441 |
| Anwendung: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 1262414-04-9 |
| MW: | 453.53 D |
ab 35,00 €
Sphingosine-1-phosphate
Artikelnummer: TGM-T21500-1mg
Description: Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, and GPR12. As an intracellular second messenger, it mobilizes Ca2+ and acts as an extracellular ligand for G-protein coupled receptors. This important lipid mediator is generated from sphingosine (HY-113498) or...
| Schlagworte: | S1P |
| Anwendung: | Bioactive lipid mediator |
| CAS | 26993-30-6 |
| MW: | 379.47 D |
292,00 €
CYM5442
Artikelnummer: TGM-T2026-1mg
Description: CYM5442 is an S1P agonist, targeting to Sphingosine. Target: S1P Receptor, LPL Receptor. Smiles: CCOc1ccc(cc1OCC)-c1nc(no1)-c1cccc2C(CCc12)NCCO. References: Poti F, et al. Vascul Pharmacol. 2012 Aug 19,57(1):56-64.
| Anwendung: | S1PR1 internalization, phosphorylation, ubiquitination agonist |
| CAS | 1094042-01-9 |
| MW: | 409.48 D |
ab 39,00 €
Mocravimod
Artikelnummer: TGM-T28080-100mg
Description: Mocravimod is an agonist of sphingosine 1-phosphate receptor type 1. Mocravimod ameliorates atherosclerosis in LDL-R-/- mice. KRP-203 attenuates rat autoimmune myocarditis. KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts. Target:...
| Schlagworte: | KRP 203 free base, KRP-203, KRP203 |
| Anwendung: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 509092-16-4 |
| MW: | 443.99 D |
ab 1.491,00 €
NIBR-0213
Artikelnummer: TGM-T28169-10mg
Description: NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis. Target: LPL Receptor. Smiles: CC=1C=C(C=C(C)C1C(N[C@H](C(O)=O)C)=O)C2=CC(N[C@H](C)C3=CC(C)=C(Cl)C=C3)=CC=C2. References: Bigaud M, Dincer Z, Bollbuck B, Dawson J, Beckmann N, Beerli C,...
| Schlagworte: | NIBR 0213 |
| Anwendung: | S1PR1 antagonist |
| CAS | 1233332-14-3 |
| MW: | 464.98 D |
ab 39,00 €
W140 (trifluoroacetate salt)
Artikelnummer: TGM-T38336-1mg
Description: Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1,...
| Schlagworte: | W140 (trifluoroacetate salt) |
| Anwendung: | S1P1 Antagonist Control |
| CAS | 909725-64-0 |
| MW: | 456.399 D |
ab 190,00 €
CAY10734
Artikelnummer: TGM-T38371-10mg
Description: CAY10734 has a wide range of applications in life science related research. Target: Others. Smiles: CC(C)Cc1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
| Anwendung: | S1P1 receptor agonist |
| CAS | 635701-59-6 |
| MW: | 391.471 D |
ab 77,00 €
D-erythro/L-threo Lysosphingomyelin (d18:1)
Artikelnummer: TGM-T37187-10mg
Description: Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P...
| Schlagworte: | D-erythro/L-threo Lysosphingomyelin (d18:1) |
| Anwendung: | Bioactive sphingolipid mixture |
| CAS | 82970-80-7 |
| MW: | 464.628 D |
ab 239,00 €