Zu "K04288" wurden 98 Artikel gefunden!
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CS 2100
Artikelnummer: Cay14396-10
CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist. It selectively induces GTPgammaS binding in CHO-K1 cells expressing human or rat S1P1 (EC50s = 4 and 1.5 nM, respectively) over those expressing human or rat S1P3 (EC50s = >20 and 7.4 µM, respectively). CS 2100 (0.1 and 1 mg/kg) transiently reduces...
| Schlagworte: | 1-[[4-ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid |
| Anwendung: | S1P1 agonist |
| CAS | 913827-99-3 |
| MW: | 461.5 D |
ab 136,00 €
W146 (trifluoroacetate salt)
Artikelnummer: CAY10009109-1
W146 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (Ki = 77 nM). It is selective for S1P1 over S1P2, S1P3, and S1P5 receptors (Kis = >10 µM for all). W146 prevents ligand-induced receptor internalization in CHO cells and inhibits the phosphorylation of ERK1 and Akt when used at a concentration of 10 µM....
| Schlagworte: | [3R-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid, mono(trifluoroacetate) |
| Anwendung: | S1P1 receptor antagonist |
| CAS | 909725-62-8 |
| MW: | 456.4 D |
ab 107,00 €
Fingolimod
Artikelnummer: TGM-T7939-100mg
Description: Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells). Target: PAK, S1P Receptor, LPL Receptor. Smiles: CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1. References: Szepanowski, Fabian, Derksen, Angelika, Steiner, Irina,et al. Fingolimod promotes peripheral...
| Schlagworte: | FTY-720A, FTY-720 |
| Anwendung: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 162359-55-9 |
| MW: | 307.47 D |
ab 49,00 €
Udifitimod
Artikelnummer: TGM-T73092-100mg
Description: Udifitimod (BMS-986166) is a potent, selective, orally active S1P1R receptor modulator with potential applications in autoimmune disease research. Target: Others. Smiles: C(O)[C@]1(N)C[C@H](CC1)C=2C=C3C(=CC2)C[C@H](CCC4=C(OC)C=CC=C4)CC3
| Schlagworte: | BMS-986166 |
| Anwendung: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 1883345-06-9 |
| MW: | 379.54 D |
ab 3.174,00 €
Ginkgolic acid 2-phosphate
Artikelnummer: TGM-T85072-10mg
Description: Ginkgolic acid 2-phosphate, a potent sphingosine 1-phosphate (S1P) agonist, induces ERK phosphorylation and interacts with S1P1 [1]. Target: Others. Smiles: C(O)(=O)C1=C(CCCCCCCCCC CCCCC)C=CC=C1OP(=O)(O)O
| Schlagworte: | Ginkgolic Acid 2-Phosphate |
| Anwendung: | Sphingosine 1-phosphate receptor 1 (S1P1) agonist |
| CAS | 2281761-58-6 |
| MW: | 428.5 D |
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Etrasimod
Artikelnummer: TGM-TQ0227-100mg
Description: Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells). Target: S1P Receptor, LPL Receptor. Smiles: OC(=O)C[C@H]1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(c3)C(F)(F)F)cc21. References: Buzard DJ, et al. Discovery of APD334:...
| Schlagworte: | APD334 |
| Anwendung: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 1206123-37-6 |
| MW: | 457.48 D |
ab 48,00 €
Siponimod
Artikelnummer: TGM-T6403-100mg
Description: BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibits >1000-fold over S1P2, S1P3 and S1P4 receptors. Target: LPL Receptor, S1P...
| Schlagworte: | BAF-312 |
| Anwendung: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 1230487-00-9 |
| MW: | 516.59 D |
ab 34,00 €
Siponimod hemifumarate
Artikelnummer: TGM-T64065-100mg
Description: Siponimod (BAF-312) hemifumarate, a selective and potent modulator of sphingosine-1-phosphate (S1P) receptors, can be used in the study of multiple sclerosis (MS). Target: Others. Smiles:...
| Anwendung: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 1234627-85-0 |
| MW: | 1149.282 D |
ab 1.520,00 €
Mocravimod hydrochloride
Artikelnummer: TGM-T12086-100mg
Description: Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1). Target: LPL Receptor, Others. Smiles: Cl.NC(CO)(CO)CCc1ccc(Sc2cccc(OCc3ccccc3)c2)cc1Cl. References: Potì F, et al. KRP-203, sphingosine 1-phosphate receptor type 1 agonist,...
| Schlagworte: | KRP-203 |
| Anwendung: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 509088-69-1 |
| MW: | 480.45 D |
ab 63,00 €
RP-001 hydrochloride
Artikelnummer: TGM-T12780L-10mg
Description: RP-001 hydrochloride is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5. Target: Others. Smiles: Cl.N#CC=1C=C(C=CC1OC(C)C)C2=NC(=NO2)C=3C=CC=C4C3CCC4NCCC(=O)O. References: Cahalan SM, et al. Actions of a...
| Anwendung: | Potent S1P1 receptor agonist |
| CAS | 1781880-34-9 |
| MW: | 468.93 D |
ab 93,00 €
S1PR1 modulator 1
Artikelnummer: TGM-T12821-100mg
Description: S1PR1 modulator 1 is a selective inhibitor of S1PR1, with a pIC50 of 7.6. Target: LPL Receptor. Smiles: N(\CCC)=C\1/N(C(=O)\C(=C\C2=CC(C)=C(OC(C)=O)C=C2)\S1)C3=C(C)C=CC=C3. References: Bell M, et al. Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1). ACS Med...
| Anwendung: | S1P1 agonist |
| CAS | 2328109-05-1 |
| MW: | 408.51 D |
ab 60,00 €
VPC 23019
Artikelnummer: TGM-T17237-100mg
Description: VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). Target: S1P Receptor, LPL Receptor. Smiles: CCCCCCCCc1cccc(NC(=O)[C@H](N)COP(O)(O)=O)c1. References: Davis...
| Anwendung: | Competitive S1P1 / S1P3 receptor antagonist |
| CAS | 449173-19-7 |
| MW: | 372.4 D |
ab 662,00 €