Zu "K04286" wurden 39 Artikel gefunden!
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Tasimelteon-d5
Artikelnummer: TGM-T70035-1mg
Description: Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits...
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, melatonin receptor agonist |
| CAS | 1962124-51-1 |
| MW: | 250.35 D |
ab 448,00 €
DH-97
Artikelnummer: TGM-T69409-1mg
Description: DH-97 is a potent MT2 melatonin receptor antagonist (pKi value = 8.03). Target: Others. Smiles: C(C=1N(C(CCCC)=O)C=2C(C1CCN)=CC=CC2)C3=CC=CC=C3
| Anwendung: | Melatonin receptor type 1B (MTNR1B) antagonist |
| CAS | 343263-95-6 |
| MW: | 334.45 D |
91,00 €
N-ACETYLTRYPTAMINE
Artikelnummer: TGM-T8600-100mg
Description: N-ACETYLTRYP TAMINE is a partial agonist for melatonin receptors in the retina. Also used for determination of serotonin N-acetyl transferase. Target: Melatonin Receptor. Smiles: CC(=O)NCCc1c[nH]c2ccccc12. References: Dubocovich M L . Characterization of a retinal melatonin receptor.[J]. Journal of...
| Anwendung: | Melatonin receptor antagonist/partial agonist |
| CAS | 1016-47-3 |
| MW: | 202.25 D |
ab 41,00 €
Luzindole
Artikelnummer: TGM-T15795-100mg
Description: Luzindole (N-0774) is a selective melatonin receptor antagonist that inhibits experimental autoimmune encephalomyelitis and exhibits antidepressant-like activity. It preferentially targets MT2 (Mel1b) over MT1 (Mel1a), with Ki values of 10.2 nM for human MT2 and 158 nM for MT1. Target: Melatonin...
| Schlagworte: | N-0774 |
| Anwendung: | Melatonin receptor MTNR1B antagonist |
| CAS | 117946-91-5 |
| MW: | 292.37 D |
ab 47,00 €
Anti-MTNR1B
Artikelnummer: CSB-PA003225.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-MTNR1B, Anti-Mel-1B-R, Anti-Mel1b receptor, Anti-Melatonin receptor type 1B, FGQTL2 antibody, Mel 1b antibody, Mel 1b... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 106,00 €
N-acetyl Tryptamine
Artikelnummer: Cay18605-10
N-acetyl Tryptamine is a structural analog of melatonin (5-methoxy-N-acetyltryptamine, Cay-14427) that binds the melatonin MT2 receptor (Ki = 41 nM). It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina. N-acetyl Tryptamine is also a reaction product of...
| Schlagworte: | N-[2-(1H-indol-3-yl)ethyl]-acetamide |
| Anwendung: | Melatonin receptor antagonist/partial agonist |
| CAS | 1016-47-3 |
| MW: | 202.3 D |
ab 66,00 €
6-hydroxy Melatonin
Artikelnummer: Cay21857-1
6-hydroxy Melatonin is an active metabolite of melatonin (Cay-14427). It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist. It inhibits dopamine release from isolated rabbit retina (IC50 =...
| Schlagworte: | N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-acetamide |
| Anwendung: | Primary active melatonin metabolite |
| CAS | 2208-41-5 |
| MW: | 248.3 D |
ab 109,00 €
Ramelteon
Artikelnummer: Cay20389-25
Ramelteon is a melatonin (MT) receptor agonist (Kis = 14, 112, and 23.1 pM for human MT1, human MT2, and chick forebrain receptors, respectively). It is selective for MT1 and MT2 over MT3 receptors (Ki = 2.65 µM for hamster brain MT3 receptors) as well as a panel of benzodiazepine, dopamine, and opiate receptors,...
| Schlagworte: | TAK-375, N-[2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]-propanamide |
| Anwendung: | Melatonin receptor agonist |
| CAS | 196597-26-9 |
| MW: | 259.3 D |
ab 125,00 €
Agomelatine
Artikelnummer: Cay13203-10
Agomelatine is an agonist of melatonin (MT) receptors and a derivative of melatonin (Cay-14427). It binds to MT1 and MT2 receptors (Kis = 0.14 and 0.41 nM, respectively) and has an EC50 value of 0.1 nM in a [35S]GTPgammaS binding assay using CHO cells expressing MT2 receptors. Agomelatine is also an antagonist of...
| Schlagworte: | S20098, N-[2-(7-methoxy-1-naphthalenyl)ethyl]-acetamide |
| Anwendung: | Melatonin analog |
| CAS | 138112-76-2 |
| MW: | 243.3 D |
ab 93,00 €
Ramelteon
Artikelnummer: LKT-R0348.25
Melatonin analog, MT1/2 agonist.
| Schlagworte: | (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b] furan-8-yl)ethyl]propionamide |
| Anwendung: | Melatonin receptor 1A agonist, melatonin receptor 1B agonist |
| CAS | 196597-26-9 |
| MW: | 259.34 D |
ab 118,00 €
-30 %
Rabattaktion
Anti-MTNR1B, C-terminal
Artikelnummer: ARG64780.100
Protein function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. [The UniProt Consortium]
| Schlagworte: | Anti-MTNR1B, Anti-Mel-1B-R, Anti-Mel1b receptor, Anti-Melatonin receptor type 1B |
| Anwendung: | ELISA, IHC (paraffin) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
784,00 €
548,80 €
2-Iodomelatonin
Artikelnummer: Cay19711-25
2-iodomelatonin is a potent agonist of melatonin receptor 1 (MT1, Ki = 28 pM) that is 5-fold selective for MT1 over MT2. It inhibits forskolin-stimulated cAMP production in CHO cells expressing human MT1 30-fold more potently than melatonin (Cay-14427) with an EC50 value of 11 pM. 2-iodomelatonin has been used to...
| Schlagworte: | N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]-acetamide |
| Anwendung: | Melatonin agonist |
| CAS | 93515-00-5 |
| MW: | 358.2 D |
ab 66,00 €