Zu "K04222" wurden 80 Artikel gefunden!
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Tradipitant
Artikelnummer: Cay41831-1
Tradipitant is a neurokinin-1 (NK1) receptor antagonist (Ki = =100 nM).Formal Name: [2-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-pyridinyl)-1H-1,2,3-triazol-4-yl]-3-pyridinyl](2-chlorophenyl)-methanone. CAS Number: 622370-35-8. Synonyms: LY686017, VLY-686. Molecular Formula: C28H16ClF6N5O. Formula Weight:...
| Schlagworte: | LY686017, VLY-686,... |
| Anwendung: | Substance-P receptor (NK-1 receptor, Tachykinin receptor 1) antagonist |
| CAS | 622370-35-8 |
| MW: | 587.9 D |
ab 54,00 €
Vofopitant dihydrochloride
Artikelnummer: TGM-T13329L-100mg
Description: Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively. It is a potential compound for the treatment of pathological vomiting. Target: Neurokinin receptor. Smiles:...
| Schlagworte: | Vofopitant 2HCl, GR 205171A |
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 168266-51-1 |
| MW: | 505.36 D |
ab 100,00 €
Netupitant metabolite Netupitant N-oxide
Artikelnummer: TGM-T12213-10mg
Description: Netupitant N-oxide is a highly selective antagonist of NK1 receptor, is Netupitant metabolite. Target: Others. Smiles: O=C(N(C1=CN=C(C=C1C=2C=CC=CC2C)N3CCN(=O)(C)CC3)C)C(C=4C=C(C=C(C4)C(F)(F)F)C(F)(F)F)(C)C
| Schlagworte: | Netupitant N-oxide |
| Anwendung: | Netupitant metabolite |
| CAS | 910808-11-6 |
| MW: | 594.59 D |
ab 157,00 €
Befetupitant
Artikelnummer: TGM-T14524-100mg
Description: Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization. Target: Neurokinin receptor. Smiles: N(C(C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)(C)C=2C(=CC(=NC2)N3CCOCC3)C4=C(C)C=CC=C4. References: Bignami F, et al. NK1 receptor...
| Schlagworte: | Ro67-5930 |
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 290296-68-3 |
| MW: | 565.55 D |
ab 500,00 €
Telmapitant
Artikelnummer: TGM-T34799-100mg
Description: Telmapitant is an antagonist of the neurokinin NK1 receptor. Target: Others. Smiles: C(O[C@H](C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)[C@]2(CC[C@]3(CN2)NC(=O)NC3=O)C4=CC=CC=C4
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 552292-58-7 |
| MW: | 515.45 D |
ab 1.521,00 €
Maropitant citrate
Artikelnummer: TGM-T35344-500mg
Description: Maropitant citrate is a useful organic compound for research related to life sciences. The catalog number is T35344 and the CAS number is 359875-09-5. Target: Neurokinin receptor. Smiles: O.OC(=O)CC(O)(CC(O)=O)C(O)=O.COc1ccc(cc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1)C(C)(C)C. References: R T...
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 359875-09-5 |
| MW: | 678.81 D |
1.397,00 €
Benzomalvin C
Artikelnummer: TGM-T38276-1mg
Description: Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor, inhibiting binding of substance P by 46% at 100 µg/ml in vitro, and a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 µM for recombinant IDO. Isolated from Penicillium, it contains an epoxide group at...
| Anwendung: | TACR1 antagonist |
| CAS | 157047-98-8 |
| MW: | 395.418 D |
1.295,00 €
Rolapitant
Artikelnummer: TGM-T3716-100mg
Description: Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity...
| Schlagworte: | SCH619734 |
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 552292-08-7 |
| MW: | 500.48 D |
ab 45,00 €
Benzomalvin B
Artikelnummer: TGM-T38033-1mg
Description: Benzomalvin B is a fungal metabolite originally isolated from Penicillium. It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P by 24% in vitro when used at a concentration of 100 µg/ml. Target: Others. Smiles: CN1C(=O)c2ccccc2-n2c(nc3ccccc3c2=O)\C1=C/c1ccccc1
| Anwendung: | Fungal metabolite, substance-P receptor antagonist |
| CAS | 157047-97-7 |
| MW: | 379.419 D |
ab 274,00 €
Elinzanetant
Artikelnummer: TGM-T38144-10mg
Description: Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion. Target: Neurokinin receptor. Smiles: [H][C@]12COCCN1C[C@@H](CO)N(C2)c1cc(c(cn1)N(C)C(=O)C(C)(C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)-c1ccc(F)cc1C. References: Alvaro, Giuseppe, Andreotti,...
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 929046-33-3 |
| MW: | 668.64 D |
ab 97,00 €
Netupitant
Artikelnummer: TGM-T6905-100mg
Description: Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM). Target: Neurokinin receptor. Smiles: CN(C(=O)C(C)(C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1cnc(cc1-c1ccccc1C)N1CCN(C)CC1. References: Rizzi A, et al. Peptides. 2012, 37(1):86-97.
| Schlagworte: | Ro 67-31898/000, CID 6451149 |
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 290297-26-6 |
| MW: | 578.59 D |
ab 49,00 €
Orvepitant
Artikelnummer: TGM-T69063-100mg
Description: Orvepitant is a potent and selective NK1 antagonist, which may be potentially useful for patients with major depressive disorder (MDD), anxiety and insomnia. Target: Others. Smiles: C(N([C@H](C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C)(=O)N2[C@H](C[C@H](CC2)N3C[C@]4(N(CC3)C(=O)CC4)[H])C5=C(C)C=C(F)C=C5
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 579475-18-6 |
| MW: | 628.62 D |
ab 2.572,00 €