Zu "K04216" wurden 22 Artikel gefunden!
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JTC-801
Artikelnummer: TGM-T6553-10mg
Description: JTC-801 is a selective opioid receptor-like 1 (ORL1) receptor antagonist with an IC50 of 94 nM and weak inhibitory effects on delta, kappa, and µ receptors. Target: Opioid Receptor. Smiles: Cl.CCc1ccc(OCc2ccccc2C(=O)Nc2ccc3nc(C)cc(N)c3c2)cc1. References: Yamada H, et al. Br J Pharmacol, 2002, 135(2),...
| Schlagworte: | JTC 801, JTC801 |
| Anwendung: | ORL1 antagonist |
| CAS | 244218-51-7 |
| MW: | 447.96 D |
ab 41,00 €
Anti-OPRL1
Artikelnummer: CSB-PA150690.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: OPRL1. Antigen Species: Human
| Schlagworte: | Anti-OOR, Anti-KOR-3, Anti-OPRL1, Anti-Nociceptin receptor, Anti-Orphanin FQ receptor, Anti-Kappa-type 3 opioid receptor,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
Anti-OPRL1
Artikelnummer: CSB-PA668398.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: OPRL1. Antigen Species: Human
| Schlagworte: | Anti-OOR, Anti-KOR-3, Anti-OPRL1, Anti-Nociceptin receptor, Anti-Orphanin FQ receptor, Anti-Kappa-type 3 opioid receptor,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
AT-121
Artikelnummer: Cay26150-100
AT-121 is a dual µ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPgammaS binding to cell membranes expressing µ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively). AT-121 (0.003-0.03 mg/kg) decreases capsaicin-induced thermal...
| Schlagworte: | N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]-sulfamide |
| Anwendung: | Dual ?-opioid / nociceptin receptor partial agonist |
| CAS | 2099681-31-7 |
| MW: | 462.6 D |
ab 84,00 €
Nociceptin (trifluoroacetate salt)
Artikelnummer: Cay15070-5
Nociceptin is a 17 amino acid neuropeptide involved in a variety of biological systems including pain, memory, stress responses, anxiety, locomotion, and feeding behavior. It is an endogenous ligand of the NOP1 (ORL1) receptor (Ki = 88 µM in CHO cells) and, though an opioid-related peptide, does not interact...
| Schlagworte: | Orphanin FQ,... |
| Anwendung: | NOP1 (OPRL1) receptor ligand |
| MW: | 1809 D |
ab 98,00 €
JTC 801
Artikelnummer: Cay21254-5
JTC 801 is an antagonist of the nociceptin receptor (ORL1, Ki = 44.5 nM, IC50 = 94 nM) that is >100-, >100-, and >3-fold more selective for ORL1 over the related delta-, kappa-, and µ-opioid receptors, respectively. It demonstrates anti-nociceptive effects in acute pain models in mice upon oral administration at 1...
| Schlagworte: | N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]-benzamide, monohydrochloride |
| Anwendung: | ORL1 antagonist |
| CAS | 244218-51-7 |
| MW: | 448 D |
ab 77,00 €
Cebranopadol
Artikelnummer: Cay29500-5
Cebranopadol is an agonist of nociceptin-, µ-, ?-, and delta-opioid receptors (Kis = 0.9, 0.7, 2.6, and 18 nM, respectively). It is greater than 100-fold selective for these receptors over a panel of more than 100 ion channels, neurotransmitter transporters, receptors, and enzymes, but does bind to the serotonin...
| Schlagworte: | GRT6005, (1alpha,4beta)-6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine |
| Anwendung: | mu-Opioid receptor agonist, nociceptin receptor agonist |
| CAS | 863513-91-1 |
| MW: | 378.5 D |
ab 97,00 €
Human OPRL1 / Nociceptin receptor ELISA Kit
Artikelnummer: G-HUFI02155.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €
Anti-OPRL1
Artikelnummer: E-AB-16005.120
The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly...
| Schlagworte: | Anti-OOR, Anti-KOR-3, Anti-OPRL1, Anti-Nociceptin receptor, Anti-Orphanin FQ receptor, Anti-Kappa-type 3 opioid receptor,... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €
-30 %
Rabattaktion
Anti-OPRL1 / Nociceptin Receptor
Artikelnummer: ARG40156.50
Protein function: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G...
| Schlagworte: | Anti-OOR, Anti-OPRL1, Anti-KOR-3, Anti-Nociceptin receptor, Anti-Orphanin FQ receptor, Anti-Kappa-type 3 opioid receptor |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
520,00 €
364,00 €
BAN ORL 24 (hydrochloride)
Artikelnummer: Cay29485-1
BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (Ki = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor). It is selective for NOP receptors over µ-, delta-, and kappa-opioid receptors (Kis = 0.19, 0.34, and >1 µM, respectively). BAN ORL 24 reduces NOP-induced...
| Schlagworte: | 1-(phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl)propyl]-2-pyrrolidinecarboxamide, dihydrochloride |
| Anwendung: | Nociceptin receptor antagonist |
| CAS | 1401463-54-4 |
| MW: | 506.5 D |
ab 98,00 €
6beta-Naltrexol-d3
Artikelnummer: Cay18350-500
6beta-Naltrexol-d3 (Cay-18350) is an analytical reference material intended for use as an internal standard for the quantification of 6beta-naltrexol (Cay-15896) by GC- or LC-MS. 6beta-Naltrexol is the major metabolite of naltrexone (Cay-ISO60192, Cay-15520). It is a neutral µ-opioid receptor antagonist (Ki = 94...
| Schlagworte: | 6beta-hydroxy Naltrexone-d3, (5alpha,6beta)-17-(cyclopropylmethyl)-4,5-epoxy-d3-morphinan-3,6,14-triol |
| Anwendung: | Analytical reference material, GC-MS, LC-MS internal standard, Quantification, Naltrexone metabolite |
| CAS | 1435727-11-9 |
| MW: | 346.4 D |
ab 163,00 €