Zu "K04215" wurden 363 Artikel gefunden!
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Loperamide (hydrochloride)
Artikelnummer: Cay14875-10
Loperamide is an opiate which potently and selectively activates µ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. Loperamide is an opiate which potently and selectively activates µ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. It is a much weaker agonist of the delta opioid receptor...
| Schlagworte: | NSC 696356, PJ 185, R 18553, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutanamide,... |
| Anwendung: | Analytical reference standard, Opiate, µ opioid receptor agonist |
| CAS | 34552-83-5 |
| MW: | 513.5 D |
ab 43,00 €
N-desmethyl Loperamide
Artikelnummer: Cay16126-1
Loperamide (Cay-14875) is an opiate which potently and selectively activates µ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. N-desmethyl Loperamide is a major metabolite of loperamide. Like loperamide, N-desmethyl loperamide is a substrate of the ATP-dependent efflux transporter, P-glycoprotein. As a...
| Schlagworte: | R 20905, 4-(4-chlorophenyl)-4-hydroxy-N-methyl-alpha,alpha-diphenyl-1-piperidinebutanamide |
| Anwendung: | Analytical reference standard, major loperamide metabolite |
| CAS | 66164-07-6 |
| MW: | 463 D |
ab 246,00 €
SR 17018
Artikelnummer: Cay24480-10
SR 17018 is an orally bioavailable and brain-penetrant agonist of µ-opioid receptors. It is functionally selective for G protein-coupled receptor signaling (EC50 = 97 nM for GTPgammaS binding in CHO cells expressing µ-opioid receptors) over beta-arrestin 2 recruitment (EC50 = >10,000 nM) at the µ-opioid receptor. SR...
| Schlagworte: | 5,6-dichloro-1-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one |
| Anwendung: | µ-opioid receptor agonist |
| CAS | 2134602-45-0 |
| MW: | 410.7 D |
ab 66,00 €
Alvimopan
Artikelnummer: TGM-T1242-100mg
Description: Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the...
| Anwendung: | µ-opioid receptor antagonist |
| CAS | 156053-89-3 |
| MW: | 424.53 D |
ab 45,00 €
Bevenopran
Artikelnummer: TGM-T14551-100mg
Description: Bevenopran (CB-5945) is a peripheral antagonist of µ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction. Target: Opioid Receptor. Smiles: COc1cc(CNCCC2CCOCC2)ccc1Oc1cnc(cn1)C(N)=O. References: Diego L, et al. Novel opioid antagonists for opioid-induced...
| Schlagworte: | ADL-5945, CB-5945 |
| Anwendung: | Targets mu-type opioid receptor (OPRM1) |
| CAS | 676500-67-7 |
| MW: | 386.44 D |
ab 96,00 €
W-15
Artikelnummer: TGM-T35098-1mg
Description: W-15 is a biochemical. Target: Others. Smiles: Clc1ccc(cc1)S(=O)(=O)N=C1CCCCN1CCc1ccccc1 , w:10.10, . References: Reffet K, Lescanne E, Bobillier C, Aussedat C, Bakhos D. Hearing aids in patients with vestibular schwannoma: Interest of the auditory brainstem responses. Clin Otolaryngol. 2018 Mar 25....
| Schlagworte: | W15 |
| Anwendung: | µ-opioid receptor agonist fentanyl analog |
| CAS | 93100-99-3 |
| MW: | 376.9 D |
291,00 €
Trefentanil hydrochloride
Artikelnummer: TGM-T29005-100mg
Description: Trefentanil hydrochloride is a short-acting analgesic. Target: Others. Smiles: Cl.O=C1N(N=NN1CCN2CCC(C=3C=CC=CC3)(N(C(=O)CC)C=4C=CC=CC4F)CC2)CC
| Anwendung: | Targets mu-type opioid receptor (OPRM1) |
| CAS | 120656-93-1 |
| MW: | 503.01 D |
ab 1.786,00 €
Naloxegol (NKTR-118)
Artikelnummer: TGM-T36374-100mg
Description: Naloxegol (NKTR-118, AZ-13337019) is an opioid receptor antagonist[1]. Target: Others. Smiles: O[C@]12[C@@]34C=5C(O[C@]3([C@@H](OCCOCCOCCO CCOCCOCCOC COC)CC1)[H])=C(O)C=CC5C[C@]2(N(CC=C)CC4)[H]. References: Yoon SC, et al. Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a...
| Anwendung: | Targets mu-type opioid receptor (OPRM1) |
| CAS | 854601-70-0 |
| MW: | 651.78 D |
ab 1.638,00 €
Herkinorin
Artikelnummer: TGM-T27534-1mg
Description: Herkinorin is an opioid analgesic and an analogue of the natural product Salvinorin A. herkinorin is a µ-opioid agonist with more than 100x higher µ-opioid affinity and 50x lower kappa-opioid affinity compared to Salvinorin A. Herkinorin is a semi-synthetic compound, made from Salvinorin B, which is...
| Schlagworte: | BF3DNCA methyl ester |
| Anwendung: | mu-type opioid receptor agonist, w/o inducing receptor internalization |
| CAS | 862073-77-6 |
| MW: | 494.53 D |
ab 237,00 €
Axelopran
Artikelnummer: TGM-T30236-25mg
Description: Axelopran(TD-1211) is potentially useful for the treatment of opioid-induced constipation, it is a potent, selective, and peripherally-restricted µ-, kappa-, and delta-opioid receptor antagonist. Target: Others. Smiles:...
| Schlagworte: | TD 1211, TD-1211, TD1211 |
| Anwendung: | Targets mu-type opioid receptor (OPRM1) |
| CAS | 949904-48-7 |
| MW: | 457.61 D |
1.491,00 €
Axelopran sulfate
Artikelnummer: TGM-T30236L-100mg
Description: Axelopran sulfate is used in Oral Therapies for Opioid-induced Bowel Dysfunction in Patients with Chronic Noncancer Pain. Target: Others. Smiles: OS(O)(=O)=O.[H][C@]12CC[C@]([H])(C[C@@H](C1)c1cccc(c1)C(N)=O)N2CCN(CC1CCCCC1)C(=O)[C@@H](O)CO , TLB:14:12:23:7.8, . References: Nee J, Zakari M, Sugarman MA,...
| Anwendung: | Targets mu-type opioid receptor (OPRM1) |
| CAS | 949904-50-1 |
| MW: | 555.69 D |
ab 2.522,00 €
Naldemedine
Artikelnummer: TGM-T33583-100mg
Description: Naldemedine (S 297995) is a peripheral selective µ-opioid receptor antagonist being developed by Shionogi for the treatment of opioid-induced adverse reactions, including constipation, nausea, and vomiting. They are usually well tolerated, mainly with mild to moderate gastrointestinal side effects....
| Schlagworte: | S 297,995, S297,995, S 297995, S297,995,Naldemedine, S-297,995, S-297995, S297995, Naldemedine |
| Anwendung: | Opioid receptor antagonist, opioid-induced laxative |
| CAS | 916072-89-4 |
| MW: | 570.64 D |
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