Zu "K04202" wurden 38 Artikel gefunden!
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NEU
Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 (trifluoroacetate salt)
Artikelnummer: Cay41469-10
Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 is a cyclic peptide and an agonist of melanocortin receptor 4 (MC4R). It induces cAMP release in HEK293 cells expressing human MC4R (EC50 = 0.28 nM). Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 is selective for MC4R over MC1R, MC3R, and MC5R (Kis = 0.55, 16.78, 56.79, and >500 nM, respectively). It...
| Schlagworte: | Ac-dR[CEHdFRWC]-NH2,... |
| Anwendung: | MC4R agonist |
| MW: | 1175.4 D |
ab 75,00 €
NEU
SNT-207707 (hydrochloride)
Artikelnummer: Cay41524-1
SNT-207707 is a melanocortin receptor 4 (MC4R) antagonist (IC50 = 5 nM). It increases food intake in mice when administered at a dose of 20 mg/kg. SNT-207707 (30 mg/kg per day) inhibits tumor-induced weight loss without inhibiting tumor growth in a C26 murine colon carcinoma model of tumor-induced cachexia.Formal...
| Schlagworte: | 2-(4-cyanophenyl)-N,N-bis(3-methylbutyl)-3-[3-(1-pyrrolidinyl)propyl]-imidazo[1,2-a]pyridine-6-carboxamide, monohydrochloride |
| Anwendung: | MC4R antagonist |
| CAS | 1064662-40-3 |
| MW: | 550.2 D |
ab 90,00 €
NEU
MCL0020 (trifluoroacetate salt)
Artikelnummer: Cay41544-1
MCL0020 is a melanocortin receptor 4 (MC4R) antagonist. It selectively inhibits [Nle4,D-Phe7]-alpha-MSH (Cay-24475) binding to recombinant human MC4R over MC1R and MC3R (IC50s = 11.63, >10,000, and 1,115 nM, respectively). MCL0020 (0.1-100 µM) inhibits alpha-MSH-induced cAMP production in COS-1 cells expressing...
| Schlagworte: | Ac-D-2Nal-Arg-2-Nal-NH2, N-acetyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-3-(2-naphthalenyl)-L-alaninamide, trifluoroacetate... |
| Anwendung: | MC4R antagonist |
| MW: | 609.7 D |
ab 134,00 €
NEU
HS-014 (trifluoroacetate salt)
Artikelnummer: Cay41556-1
HS-014 is an antagonist of melanocortin receptor 4 (MC4R, Ki = 3.16 nM). It is selective for MC4R over MC1R, MC3R, and MC5R (Kis = 108, 54.4, and 694 nM, respectively). HS-014 inhibits cAMP accumulation induced by alpha-melanocyte-stimulating hormone (alpha-MSH) in COS-1 cells expressing MC4R in a...
| Schlagworte: | Cyclic [Ac-Cys11, D-Nal14, Cys18, Asp-NH2]-beta-MSH(11-22), cyclic (1->8)-disulfide... |
| Anwendung: | MC4R antagonist |
| MW: | 1563.8 D |
ab 90,00 €
NEU
HS-024 (trifluoroacetate salt)
Artikelnummer: Cay41557-1
HS-024 is a cyclic peptide antagonist of melanocortin receptor 4 (MC4R, Ki = 0.29 nM). It is selective for MC4R over MC1R, MC3R, and MC5R (Kis = 18.6, 5.45, and 3.29 nM, respectively). HS-024 (100 nM) inhibits cAMP accumulation induced by alpha-melanocyte-stimulating hormone (alpha-MSH, Cay-29923) in COS-1 cells...
| Schlagworte: | Ac-Cys-Nle-Arg-His-D-Nal-Arg-Trp-Gly-Cys-NH2, cyclic [AcCys3,Nle4,Arg5,D-Nal7,Cys-NH211]alpha-MSH-(3-11), cyclic... |
| Anwendung: | MC4R antagonist |
| MW: | 1266.5 D |
ab 285,00 €
NEU
RO27-3225 (trifluoroacetate salt)
Artikelnummer: Cay41558-1
RO27-3225 is a peptide agonist of melanocortin receptor 4 (MC4R). It selectively induces cAMP production in cells expressing human MC4R (EC50 = 0.3 nM) over cells expressing MC1R, MC3R, or MC5R (EC50s = 1.1, 97.9, and 139.4 nM, respectively). In vivo, RO27-3225 (3, 5, and 10 nmol/animal) reduces food intake in rats,...
| Schlagworte: | Oxobutyl-His-Phe-Arg-Trp-{Sar}-NH2, N-(1-oxobutyl)-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-N2-methyl-glycinamide,... |
| Anwendung: | Peptide MC4R agonist |
| CAS | 1373926-49-8 |
| MW: | 784.9 D |
ab 35,00 €
NEU
PF-00446687
Artikelnummer: Cay41739-1
PF-00446687 is an agonist of melanocortin receptor 4 (MC4R). It selectively activates adenylyl cyclase in HEK293 cells expressing MC4R (EC50 = 0.012 µM) over HEK293 cells expressing MC1R, MC3R, or MC5R (EC50s = 1.02, 1.16, and 1.98 µM, respectively). PF-00446687 (1 mg/kg per day) increases time spent huddling and in...
| Schlagworte: | PF446687,... |
| Anwendung: | MC4R agonist |
| CAS | 862281-92-3 |
| MW: | 470.6 D |
ab 204,00 €
SHU 9119
Artikelnummer: TGM-T16879-1mg
Description: SHU 9119 is an effective human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist (IC50: 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively). Target: Others. Smiles:...
| Anwendung: | MC1R agonist, MC4R antagonist |
| CAS | 168482-23-3 |
| MW: | 1074.258 D |
ab 189,00 €
THIQ
Artikelnummer: TGM-T8485-100mg
Description: THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively). Target: Melanocortin Receptor. Smiles: ClC1=CC=C(C[C@@H](NC(=O)[C@H]2CC3=CC=CC=C3CN2)C(=O)N2CCC(CN3C=NC=N3)(CC2)C2CCCCC2)C=C1. References: Huang H, et al. A small molecule agonist...
| Anwendung: | MC4R agonist |
| CAS | 312637-48-2 |
| MW: | 589.17 D |
ab 48,00 €
Melanocortin receptor 4 (Mc4r), mouse, recombinant
Artikelnummer: CSB-CF013561MO.100
Organism: Mus musculus (Mouse). Source: in vitro E.coli expression system. Expression Region: 1-332aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MNSTHHHGMY TSLHLWNRSS YGLHGNASES LGKGHPDGGC YEQLFVSPEV FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE TIVITLLNST...
| Schlagworte: | Mc4r, MC4-R, Melanocortin receptor 4, Recombinant Mouse Melanocortin receptor 4 (Mc4r) |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | mouse |
| MW: | 43.0 kD |
ab 1.413,00 €
Human MC4R Protein, hFc Tag
Artikelnummer: DIM-PME101425.10
Recombinant human MC4R Protein with C-terminal human Fc tag. MC4R(Met1-Gln43) hFc(Glu99-Ala330), Protein function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is...
| Schlagworte: | BMIQ20 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 31.0 kD |
ab 98,00 €
MC4R (human) full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP100122.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Schlagworte: | MC4R, MC4-R, Melanocortin receptor 4, BMIQ20, Human MC4R full length protein-synthetic nanodisc |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 36.9 kD |
ab 1.260,00 €