Zu "K04197" wurden 54 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Atrasentan (hydrochloride)
Artikelnummer: Cay31238-10
Atrasentan is an antagonist of endothelin receptor type A (ETA, Ki = 69 pM for the human receptor). It is selective for ETA over ETB (Ki = 139 nM for the human receptor) and a panel of 29 other receptors at 10 µM. Atrasentan inhibits endothelin-1-induced secretion of arachidonic acid (Cay-90010, Cay-90010.1,...
| Schlagworte: | A-127722, A-147627, ABT-627,... |
| Anwendung: | ETA antagonist |
| CAS | 195733-43-8 |
| MW: | 547.1 D |
ab 108,00 €
Darusentan
Artikelnummer: TGM-T5458-100mg
Description: Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in large and small arteries. Target: Endothelin Receptor. Smiles: COc1cc(OC)nc(O[C@H](C(O)=O)C(OC)(c2ccccc2)c2ccccc2)n1. References: Liang F, et al. Darusentan is a potent inhibitor of endothelin signaling and function in...
| Schlagworte: | Lu-135252 |
| Anwendung: | ETA receptor antagonist |
| CAS | 171714-84-4 |
| MW: | 410.43 D |
ab 45,00 €
Zibotentan
Artikelnummer: TGM-T6258-10mg
Description: Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3. Target: Apoptosis, Endothelin Receptor. Smiles: COc1nc(C)cnc1NS(=O)(=O)c1cccnc1-c1ccc(cc1)-c1nnco1. References: Morris CD, et al. Br J Cancer, 2005, 92(12), 2148-2152.
| Schlagworte: | ZD4054 |
| Anwendung: | Targets endothelin receptor type A (EDNRA) |
| CAS | 186497-07-4 |
| MW: | 424.43 D |
ab 37,00 €
Bosentan-d4
Artikelnummer: TGM-T73820-5mg
Description: Bosentan-d4, the deuterium-labeled variant of Bosentan, serves as a competitive dual antagonist against endothelin-1 (ET) by targeting both ET A and ET B receptors. It exhibits binding affinities with K i values of 4.7 nM for ET A and 95 nM for ET B in human SMC. Smiles:...
| Anwendung: | GC-MS, LC-MS, internal standard |
| CAS | 1065472-77-6 |
| MW: | 555.64 D |
687,00 €
EDNRA Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01294-100ug
Description: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
| Schlagworte: | EDNRA, ETRA, ETA, Endothelin-1 receptor, ET-A, ETA-R, hET-AR |
| MW: | 8.8 kD |
ab 229,00 €
Clazosentan
Artikelnummer: TGM-T64084-100mg
Description: Clazosentan (Ro 61-1790) is a selective antagonist of the endothelin A receptor (ETAreceptor) that inhibits ET-1-mediated vasoconstriction, preventing cerebral vasospasm and vasospasm-associated cerebral infarction. Target: Endothelin Receptor. Smiles:...
| Schlagworte: | Ro 61-1790, VML 588, AXV-034343 |
| Anwendung: | Targets endothelin receptor type A (EDNRA) |
| CAS | 180384-56-9 |
| MW: | 577.57 D |
ab 83,00 €
BQ-123
Artikelnummer: TGM-T6792-100mg
Description: BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. Target: Endothelin Receptor. Smiles: [H][C@@]12CCCN1C(=O)[C@@]([H])(CC(O)=O)NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C. References: Ihara M, et al. J Cardiovasc Pharmacol. 1992, 12,...
| Schlagworte: | BQ123 |
| Anwendung: | Endothelin receptor A antagonist |
| CAS | 136553-81-6 |
| MW: | 610.7 D |
ab 81,00 €
Ambrisentan
Artikelnummer: TGM-T1655-10mg
Description: Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but has yet to be implicated in cases of clinically apparent acute liver injury. Target:...
| Schlagworte: | BSF 208075, BSF-208075, LU 208075 |
| Anwendung: | Targets endothelin receptor type A (EDNRA) |
| CAS | 177036-94-1 |
| MW: | 378.42 D |
ab 31,00 €
Macitentan-d4
Artikelnummer: TGM-T11934-1mg
Description: Macitentan-d4 (ACT-064992 D4) is a deuterated substitute for Macitentan and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor).Macitentan-d4 is less toxic than Macitentan, has a longer half-life, and can be used to study endothelin receptor-mediated diseases. Smiles:...
| Schlagworte: | Macitentan D4, ACT-064992 D4 |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, dual EDNRA / EDNRB antagonist |
| CAS | 1258428-05-5 |
| MW: | 592.3 D |
ab 261,00 €
Sitaxsentan
Artikelnummer: TGM-T12924-100mg
Description: Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to its receptors, thereby eliminating the harmful effects of endothelin. Target: Endothelin Receptor. Smiles:...
| Schlagworte: | IPI 1040, TBC-11251 |
| Anwendung: | Targets endothelin receptor type A (EDNRA) |
| CAS | 184036-34-8 |
| MW: | 454.9 D |
ab 91,00 €
Fandosentan potassium
Artikelnummer: TGM-T31744-25mg
Description: Fandosentan potassium is a bio-active chemical. Detailed information has not been published. Target: Others. Smiles: [K].CCc1cc(cc2OCOc12)C1=C(N(c2ccccc2C(F)(F)F)S(=O)(=O)c2ccccc12)C(O)=O , t:13,
| Schlagworte: | PD 180988, PD 180988-0016, UNII-14U0D2SA4K |
| Anwendung: | Targets endothelin receptor type A (EDNRA) |
| CAS | 221246-12-4 |
| MW: | 556.57 D |
1.520,00 €
Endothelin-1 receptor (EDNRA), partial, human, recombinant
Artikelnummer: CSB-YP007403HU1.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 21-80aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: DNPERYSTNL SNHVDDFTTF RGTELSFLVT THQPTNLVLP SNGSMHNYCP QQTKITSAFK. Purity: Greater than 90% as determined by SDS-PAGE. Endotoxin: Not test. Biological...
| Schlagworte: | ETA, ET-A, ETA-R, hET-AR, Endothelin-1 receptor, Endothelin receptor type A, Recombinant Human Endothelin-1 receptor... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 8.8 kD |
ab 242,00 €