Zu "K04177" wurden 66 Artikel gefunden!
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NEU
CCR2 Antagonist
Artikelnummer: Cay19542-1
CCR2 antagonist is an antagonist of chemokine (C-C motif) receptor 2 (CCR2). It binds to CCR2 in a radioligand binding assay using peripheral blood mononuclear cells (PBMCs, IC50 = 5.1 nM). CCR2 antagonist inhibits chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) in PBMCs (IC50 = 1 nM). In vivo, CCR2...
| Schlagworte: | BMS CCR2-22,... |
| Anwendung: | CCR2 antagonist |
| CAS | 445479-97-0 |
| MW: | 593.7 D |
ab 75,00 €
RS102895 hydrochloride
Artikelnummer: TGM-T12773-100mg
Description: RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM). Target: CCR, 5-HT Receptor, Others. Smiles: Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc2ccccc32)cc1. References: Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding...
| Anwendung: | CCR2 antagonist |
| CAS | 1173022-16-6 |
| MW: | 426.86 D |
ab 40,00 €
![CCR2-RA-[R]](https://www.biomol.com/media/image/20/e0/7c/TGM-T14900-1mL_200x200.png "CCR2-RA-[R]")
CCR2-RA-[R]
Artikelnummer: TGM-T14900-100mg
Description: CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM). Target: CCR. Smiles: CC(=O)C1=C(O)C(=O)N([C@@H]1C1CCCCC1)c1ccc(Cl)cc1F. References: Zweemer AJ, et al. Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2. Mol Pharmacol. 2013...
| Anwendung: | Allosteric CCR2 antagonist |
| CAS | 512177-83-2 |
| MW: | 351.8 D |
ab 39,00 €
CCX140
Artikelnummer: TGM-T14909-100mg
Description: CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2. Target: CCR. Smiles: Cc1cnc(C(=O)c2ncnc3[nH]ccc23)c(NS(=O)(=O)c2ccc(Cl)c(c2)C(F)(F)F)c1. References: Sullivan T, et al. CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice. Am J Physiol Renal...
| Schlagworte: | CCX140-B |
| Anwendung: | Targets C-C chemokine receptor type 2 (CCR2, CD192) |
| CAS | 1100318-47-5 |
| MW: | 495.86 D |
ab 50,00 €
BMS-813160
Artikelnummer: TGM-T4584-100mg
Description: BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular. Target: CCR. Smiles: CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(nn23)C(C)(C)C)C1=O)NC(C)(C)C. References: Norman P. et al. A dual CCR2/CCR5 chemokine antagonist, BMS-813160? Evaluation of...
| Schlagworte: | BMS 813160 |
| Anwendung: | CCR2/CCR5 dual antagonist |
| CAS | 1286279-29-5 |
| MW: | 484.64 D |
ab 56,00 €
RS 504393
Artikelnummer: TGM-T5384-100mg
Description: RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 µM for human recombinant CCR2 and CCR1). Target: CCR. Smiles: Cc1oc(nc1CCN1CCC2(CC1)OC(=O)Nc1ccc(C)cc21)-c1ccccc1. References: Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b...
| Anwendung: | CCR2 chemokine receptor antagonist |
| CAS | 300816-15-3 |
| MW: | 417.5 D |
ab 43,00 €
Ilacirnon sodium
Artikelnummer: TGM-T71450-100mg
Description: Ilacirnon sodium is a potent CCR2 antagonist that may be useful in the treatment of renal diseases including Focal Segmental Glomerulosclerosis and Diabetic Nephropathy. Target: Others
| Anwendung: | Targets C-C chemokine receptor type 2 (CCR2, CD192) |
| CAS | 1100319-36-5 |
| MW: | 517.84 D |
ab 1.491,00 €
Plozalizumab
Artikelnummer: TGM-T77118-100mg
Description: Plozalizumab (MLN-1202) is a humanized, selective, and potent anti-CCR2 antibody with antitumor activity, used in the study of malignant melanoma. Target: CCR. References: Jahchan NS, et al. Tuning the Tumor Myeloid Microenvironment to Fight Cancer. Front Immunol. 2019 Jul 25,10:1611.
| Schlagworte: | MLN-1202 |
ab 364,00 €
CCR2b Protein-VLP, Human, Recombinant
Artikelnummer: TGM-TMPK-00879-100ug
Description: The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates...
| Schlagworte: | CMKBR2, MCP-1-R, C-C CKR-2, CCR2, CCR-2 |
| MW: | 42.9 kD |
ab 1.589,00 €
INCB3344
Artikelnummer: TGM-TQ0103-100mg
Description: INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 nM (mCCR2) and in 3.8 nM (hCCR2) antagonism of chemotaxis activity. Target: CCR. Smiles:...
| Anwendung: | CCR2 antagonist |
| CAS | 1262238-11-8 |
| MW: | 577.59 D |
ab 63,00 €
MK-0812
Artikelnummer: TGM-TQ0182-10mg
Description: MK-0812 is an effective and specific CCR2 antagonist. Target: CCR. Smiles: [H][C@]1(CC[C@](C1)(C(C)C)C(=O)N1CCc2ncc(cc2C1)C(F)(F)F)N[C@@]1([H])CCOC[C@@]1([H])OC. References: Wisniewski T, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a...
| Anwendung: | CCR2 antagonist |
| CAS | 624733-88-6 |
| MW: | 469.54 D |
ab 179,00 €
Cenicriviroc
Artikelnummer: TGM-TQ0297-100mg
Description: Cenicriviroc (TAK-652) is an orally active, dual CCR2/CCR5 antagonist that inhibits both HIV-1 and HIV-2, exhibiting potent anti-infective and anti-inflammatory activity. Target: CCR, HIV Protease. Smiles: CCCCOCCOc1ccc(cc1)-c1ccc2N(CC(C)C)CCC\C(=C/c2c1)C(=O)Nc1ccc(cc1)S(=O)Cc1cncn1CCC. References:...
| Schlagworte: | TAK-652, TBR-652 |
| Anwendung: | Targets C-C chemokine receptor type 5 (CCR5, CD195) |
| CAS | 497223-25-3 |
| MW: | 696.94 D |
ab 62,00 €