Zu "K04162" wurden 30 Artikel gefunden!
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Cerlapirdine
Artikelnummer: TGM-T30798-100mg
Description: Cerlapirdine (PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine is already in clinical development for the treatment of cognitive disorders related to Alzheimer's disease and schizophrenia. It works by acting as a selective 5-HT6 receptor...
| Schlagworte: | WAY-262,531, PF-05212365, SAM 531, PF05212365, SAM531, P -05212365, SAM-531 |
| Anwendung: | Targets 5-hydroxytryptamine receptor 6 (HTR6) |
| CAS | 925448-93-7 |
| MW: | 409.5 D |
ab 74,00 €
AVN-492
Artikelnummer: TGM-T5179-100mg
Description: AVN-49 is a potent and selective 5-HT6R Antagonist (Ki: 91 pM). Target: 5-HT Receptor. Smiles: CNc1nn2c(C)c(N(C)C)c(C)nc2c1S(=O)(=O)c1ccccc1. References: Ivachtchenko AV, et al. AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation. J Alzheimers Dis. 2017,58(4):1043-1063.
| Schlagworte: | AVN492 |
| Anwendung: | 5-HT6R antagonist |
| CAS | 1220646-23-0 |
| MW: | 359.45 D |
ab 34,00 €
Cerlapirdine hydrochloride
Artikelnummer: TGM-T68330-100mg
Description: Cerlapirdine, also known as SAM-531, WAY-262,531 and PF-05212365, is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has been in clinical development for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia. As of...
| Anwendung: | Targets 5-hydroxytryptamine receptor 6 (HTR6) |
| CAS | 925447-04-7 |
| MW: | 445.96 D |
ab 1.520,00 €
Anti-HTR6
Artikelnummer: CSB-PA009366.50
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-HTR6, Anti-5-HT6, Anti-5-HT-6, Anti-Serotonin receptor 6, Anti-5-hydroxytryptamine receptor 6, 5 HT 6 antibody, 5 HT6... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
126,00 €
Anti-HTR6
Artikelnummer: CSB-PA152529.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-HTR6, Anti-5-HT6, Anti-5-HT-6, Anti-Serotonin receptor 6, Anti-5-hydroxytryptamine receptor 6, 5 HT 6 antibody, 5 HT6... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
283,00 €
Lu AE58054
Artikelnummer: Cay27335-10
LU AE58054 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.83 nM). It is selective for 5-HT6 over other 5-HT receptor subtypes (Kis = 250 to >10,000 nM) and 70 other targets but does bind to alpha1A- and alpha1B-adrenergic receptors (alpha1B-ARs, Kis = 21 and 22 nM, respectively). LU AE58054...
| Schlagworte: | 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-1H-indole-3-ethanamine |
| Anwendung: | Serotonin receptor 5-HT6 antagonist |
| CAS | 467459-31-0 |
| MW: | 398.4 D |
81,00 €
SB-258585 (hydrochloride)
Artikelnummer: Cay17416-10
SB-258585 is a potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53). It displays over 100-fold selectivity for 5-HT6 over other 5-HT, dopamine, and alpha-adrenergic receptors. Radiolabeled forms of SB-258585 have been used to evaluate other potential ligands of the 5-HT6 receptor. SB-258585 has...
| Schlagworte: | 4-iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-benzenesulfonamide, monohydrochloride |
| Anwendung: | 5-HT6 receptor antagonist |
| CAS | 1216468-02-8 |
| MW: | 523.8 D |
ab 44,00 €
Anti-5-HT6
Artikelnummer: A304-401A
Protein function: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic...
| Schlagworte: | Anti-HTR6, Anti-5-HT6, Anti-5-HT-6, Anti-Serotonin receptor 6, Anti-5-hydroxytryptamine receptor 6 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
SB-742457
Artikelnummer: Cay22200-1
SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM). SB-742457 (1 µM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an...
| Schlagworte: | GSK742457, 3-(phenylsulfonyl)-8-(1-piperazinyl)-quinoline |
| Anwendung: | 5-HT6 receptor antagonist |
| CAS | 607742-69-8 |
| MW: | 353.4 D |
ab 52,00 €
MS 245 (oxalate)
Artikelnummer: Cay11936-1
MS 245 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 2.3 nM for the human recombinant receptor). It is selective for 5-HT6 over 5-HT2A and 5-HT2C receptors (Kis = 130 and 23 nM, respectively), as well as 5-HT1A, 5-HT1B, 5-HT1E, 5-HT3, and 5-HT7 receptors (Kis = 720, 9,200, 4,220, 2,390, and...
| Schlagworte: | 5-methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine, monoethanedioate |
| Anwendung: | 5-HT6 antagonist |
| CAS | 275363-58-1 |
| MW: | 448.5 D |
ab 52,00 €
WAY-208466 (hydrochloride)
Artikelnummer: Cay11938-1
WAY-208466 is a selective 5-HT6 receptor agonist (EC50 = 7.3 nM at the human 5-HT6 receptor). It has been shown to increase cortical GABA levels in rat frontal cortex, producing anxiolytic-like effects in vivo. Formal Name: 3-[(3-fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine,...
| Schlagworte: | 3-[(3-fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine, dihydrochloride |
| Anwendung: | 5-HT6 agonist |
| CAS | 1207064-61-6 |
| MW: | 420.3 D |
ab 44,00 €
SB-271046 (hydrochloride)
Artikelnummer: Cay18513-10
SB-271046 is an orally-available antagonist of the serotonin (5-hydroxytryptamine, or 5-HT, Cay-14332) receptor 5-HT6 (pKi = 9.02-8.92). It is at least 100-fold selective for 5-HT6 over other 5-HT receptors, as well as 55 other receptors, enzymes, and ion channels. While it does not alter basal levels of 5-HT,...
| Schlagworte: | 5-chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-benzo[b]thiophene-2-sulfonamide, monohydrochloride |
| Anwendung: | 5-HT6 antagonist |
| CAS | 209481-24-3 |
| MW: | 488.4 D |
ab 111,00 €