Zu "K04157" wurden 234 Artikel gefunden!

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IHCH-7079
IHCH-7079

Artikelnummer: Cay41988-1

IHCH-7079 is a beta-arrestin-biased agonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 16.98 nM). It reduces the time spent immobile in the tail suspension and forced swim tests in mice in a model of acute restraint stress-induced depression when administered at a dose of 10 mg/kg, and this effect can be...
Schlagworte: 2,3,6bR,7,8,9,10,10aS-octahydro-8-[2-(2-methoxyphenyl)ethyl]-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline
Anwendung: 5-HT2A beta-arrestin-biased agonist
CAS 2957888-63-8
MW: 363.5 D
ab 116,00 €
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Pimavanserin
Pimavanserin

Artikelnummer: TGM-T2076-100mg

Description: Pimavanserin (ACP-103)(ACP-103) is an effective and specific 5-HT2A receptor inverse agonist (mean pIC50: 8.7, in the cell-based functional assay). Pimavanserin is an atypical antipsychotic used in the treatment of hallucinations and psychosis in patients with Parkinson disease. Target: 5-HT Receptor....
Schlagworte: ACP-103
Anwendung: HTR2A inverse agonist
CAS 706779-91-1
MW: 427.55 D
ab 30,00 €
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Lurasidone
Lurasidone

Artikelnummer: TGM-T21337-5mg

Description: Lurasidone (SM-13496) is an antagonist of dopamine D2 and 5-HT7 receptors (IC50 = 1.68 and 0.495 nM, respectively) and a partial agonist of the 5-HT1A receptor (IC50 = 6.75 nM). Target: 5-HT Receptor, Dopamine Receptor. Smiles:...
Schlagworte: SM-13496
Anwendung: HTR1A / HTR2 / HTR7 / DRD2 modulator
CAS 367514-87-2
MW: 492.68 D
ab 39,00 €
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Tedatioxetine
Tedatioxetine

Artikelnummer: TGM-T34795-100mg

Description: Tedatioxetine (Lu AA24530) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with antidepressant properties.Tedatioxetine acts as a CYP2D6 substrate. Target: Dopamine Receptor, Serotonin Transporter. Smiles: S(C1=CC=C(C=C1)C)C=2C=CC=CC2C3CCNCC3. References: Javelot H....
Schlagworte: Lu AA-24530, Lu AA24530, Lu AA 24530
Anwendung: Targets phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
CAS 508233-95-2
MW: 283.43 D
ab 286,00 €
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Setoperone
Setoperone

Artikelnummer: TGM-T34626-100mg

Description: Setoperone, as a sensitive radioligand, can be commonly used in position emission tomography (PET) imaging. Target: Others. Smiles: O=C1N2C(=NC(C)=C1CCN3CCC(C(=O)C4=CC=C(F)C=C4)CC3)SCC2. References: Beversdorf DQ, Nordgren RE, Bonab AA, Fischman AJ, Weise SB, Dougherty DD, Felopulos GJ, Zhou FC, Bauman...
Schlagworte: R 52245, R52245, R-52245
Anwendung: Targets 5-hydroxytryptamine receptor 2 (HTR2)
CAS 86487-64-1
MW: 401.5 D
ab 1.491,00 €
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Altanserin tartrate
Altanserin tartrate

Artikelnummer: TGM-T29913L-25mg

Description: Altanserin tartrate is a compound that binds to the 5-HT2A receptor. Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain. Target: Others. Smiles:...
Schlagworte: R-53,200
Anwendung: Targets 5-hydroxytryptamine receptor 2 (HTR2)
CAS 79449-96-0
MW: 561.58 D
ab 1.491,00 €
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SB 242084 dihydrochloride
SB 242084 dihydrochloride

Artikelnummer: TGM-T37114-2mg

Description: SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. Target: Others. Smiles: Cl.Cl.Cc1cc2CCN(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2cc1Cl. References: Kennett GA, et al. SB 242084, a selective and brain...
Anwendung: 5-HT2C receptor antagonist
CAS 1049747-87-6
MW: 467.78 D
72,00 €
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CLOZAPINE N-OXIDE
CLOZAPINE N-OXIDE

Artikelnummer: TGM-T4494-100mg

Description: Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist. Target: AChR, Drug...
Anwendung: 5-HT2 serotonin receptor antagonist
CAS 34233-69-7
MW: 342.82 D
ab 31,00 €
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Volinanserin
Volinanserin

Artikelnummer: TGM-T5389-10mg

Description: Volinanserin (MDL100907) (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 adrenergic and sigma receptors. Target: 5-HT Receptor. Smiles: COc1cccc([C@H](O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC....
Schlagworte: M 100907, MDL100907
Anwendung: Potent, selective serotonin receptor 5-HT2A antagonist
CAS 139290-65-6
MW: 373.46 D
ab 80,00 €
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idalopirdine
idalopirdine

Artikelnummer: TGM-T7103-100mg

Description: Idalopirdine (Lu AE58054), a selective 5-HT6 receptor antagonist( Ki : 0.83 nM),as a treatment for Alzheimer's disease. Target: 5-HT Receptor. Smiles: C(CNCC1=CC(OCC(C(F)F)(F)F)=CC=C1)C=2C=3C(NC2)=CC(F)=CC3. References: Galimberti D , Scarpini E . Idalopirdine as a treatment for Alzheimer's disease[J]....
Schlagworte: Lu AE58054
Anwendung: Targets 5-hydroxytryptamine receptor 6 (HTR6)
CAS 467459-31-0
MW: 398.37 D
ab 79,00 €
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Amesergide
Amesergide

Artikelnummer: TGM-T71213-100mg

Description: Amesergide is a serotonin antagonist. Target: Others. Smiles: C(C)(C)N1C2=C3C([C@@]4([C@@](CC3=C1)(N(C)C[C@H](C(NC5CCCCC5)=O)C4)[H])[H])=CC=C2
Anwendung: Targets 5-hydroxytryptamine receptor 2 (HTR2)
CAS 121588-75-8
MW: 393.56 D
ab 2.080,00 €
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7-FluorotryptaMine HCl
7-FluorotryptaMine HCl

Artikelnummer: TGM-T77673-100mg

Description: 7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated beta-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer. Target: Arrestin, GPR. Smiles: Cl.FC1=CC=CC=2C(=CNC12)CCN. References: Zhao X, et...
Anwendung: Tryptamine derivative, potential 5-HT2C agonist
CAS 159730-09-3
MW: 214.67 D
ab 32,00 €
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