Zu "K04152" wurden 35 Artikel gefunden!
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JNJ-10191584 (maleate)
Artikelnummer: Cay42265-10
JNJ-10191584 is a histamine H4 receptor antagonist (Ki = 79. nM). It is selective for the histamine H4 receptor over the histamine H3 receptor (Ki = 3,981 nM). JNJ-10191584 inhibits eosinophil and mast cell chemotaxis (IC50s = 530 and 138 nM, respectively). It decreases colonic injury in a rat model of TNBS-induced...
| Schlagworte: | VUF 6002, 1-[(5-chloro-1H-benzimidazol-2-yl)carbonyl]-4-methyl-piperazine, 2Z-butenedioate |
| Anwendung: | Histamine H4 receptor antagonist |
| CAS | 869497-75-6 |
| MW: | 394.8 D |
ab 70,00 €
Adriforant
Artikelnummer: TGM-T68280-100mg
Description: Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for...
| Anwendung: | Targets histamine receptor H4 (HRH4) |
| CAS | 943057-12-3 |
| MW: | 262.35 D |
ab 1.520,00 €
JNJ-39758979
Artikelnummer: Cay41084-10
JNJ-39758979 is a histamine H4 receptor antagonist (Ki = 12.5 nM for the human receptor). It is selective for the histamine H4 receptor over histamine H1, H2, and H3 receptors (Kis = >1,000, >1,000, and 1,043 nM, respectively, for the human receptors), as well as 48 other receptors, ion channels, and transporters at...
| Schlagworte: | 4-[(3R)-3-amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyrimidinamine |
| Anwendung: | Histamine H4 receptor antagonist |
| CAS | 1046447-90-8 |
| MW: | 221.3 D |
ab 129,00 €
Toreforant
Artikelnummer: TGM-T17118-100mg
Description: Toreforant is an effective and selective histamine H4 receptor antagonist (Ki at the human receptor: 8.4 nM). Target: Histamine Receptor. Smiles: CN1CCC(CCCNc2ncc(-c3nc4cc(C)cc(C)c4[nH]3)c(C)n2)CC1
| Schlagworte: | JNJ-38518168 |
| Anwendung: | Targets histamine receptor H4 (HRH4) |
| CAS | 952494-46-1 |
| MW: | 392.54 D |
ab 1.671,00 €
Anti-HRH4
Artikelnummer: CSB-PA040185.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-H4R, Anti-HH4R, Anti-HRH4, Anti-AXOR35, Anti-GPRv53, Anti-SP9144, Anti-Pfi-013, Anti-GPCR105, Anti-Histamine H4... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 126,00 €
JNJ-7777120
Artikelnummer: Cay10011925-10
JNJ-7777120 is a potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors. Its Ki values for the histamine H1-3 receptors exceed 1 µM, regardless of species, and it has no or negligible effects on a range of other receptors and...
| Schlagworte: | (5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone |
| Anwendung: | Histamine H4 receptor antagonist |
| CAS | 459168-41-3 |
| MW: | 277.8 D |
ab 28,00 €
VUF10460
Artikelnummer: Cay14665-5
VUF10460 is a histamine H4 receptor agonist (Kis = 5.01 and 14.13 nM for the human and rat receptors, respectively). It is selective for the rat histamine H4 receptor over the rat histamine H3 receptor (Kis = 34.67 and 1,778.28 nM, respectively). VUF10460 (10 mg/kg) potentiates the formation of HCl-induced ulcers in...
| Schlagworte: | 4-(4-methyl-1-piperazinyl)-6-phenyl-2-pyrimidinamine |
| Anwendung: | Histamine H4 receptor agonist |
| CAS | 1028327-66-3 |
| MW: | 269.4 D |
ab 44,00 €
4-Methylhistamine (hydrochloride)
Artikelnummer: Cay23761-1
4-Methylhistamine is a histamine H4 receptor agonist (Ki = 50 nM). It is >100-fold selective for H4 over other histamine receptors. 4-Methylhistamine inhibits CRE-beta-galactosidase activity induced by forskolin (Cay-11018) with an EC50 value of 39.8 nM in SK-N-MC cells transfected with the human H4 receptor. It...
| Schlagworte: | 4-methyl-1H-imidazole-5-ethanamine, dihydrochloride |
| Anwendung: | Histamine H4 receptor agonist |
| CAS | 36376-47-3 |
| MW: | 198.1 D |
ab 44,00 €
Imetit (hydrobromide)
Artikelnummer: Cay29517-5
Imetit is a histamine H3 and H4 receptor agonist (Kis = 0.3 and 2.7 nM, respectively, in radioligand binding assays). It is selective for histamine H3 and H4 receptors over H1 and H2 receptors at concentrations up to 100 µM, as well as the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 240 nM). Imetit reduces...
| Schlagworte: | VUF 8325, carbamimidothioic acid, 2-(1H-imidazol-5-yl)ethyl ester, dihydrobromide |
| Anwendung: | Histamine H3 & H4 receptor agonist |
| CAS | 32385-58-3 |
| MW: | 332.1 D |
ab 100,00 €
VUF8430 (hydrobromide)
Artikelnummer: Cay27682-1
VUF8430 is a histamine H4 receptor agonist (Ki = 31.6 nM). It is selective for histamine H4 over H1 and H3 receptors in radioligand binding assays (Kis = >1 and 1 µM, respectively) and is less active in isolated guinea pig atria, which endogenously expresses high levels of H2 receptors (pD2 = 3.8). VUF8430 inhibits...
| Schlagworte: | carbamimidothioic acid, 2-[(aminoiminomethyl)amino]ethyl ester, dihydrobromide |
| Anwendung: | Histamine H4 receptor agonist |
| CAS | 100130-32-3 |
| MW: | 323.1 D |
ab 52,00 €
Histamine
Artikelnummer: Cay33828-5
Histamine is a biogenic amine. It is produced from histidine in basophils, mast cells, gastric enterochromaffin-like (ECL) cells, and histaminergic neurons by histidine decarboxylase (HDC). Histamine activates the G protein-coupled histamine H1-4 receptors to regulate allergic and inflammatory responses, gastric...
| Schlagworte: | NSC 33792, 1H-imidazole-5-ethanamine |
| Anwendung: | Biogenic amine, histamine H1-4 receptor agonist |
| CAS | 51-45-6 |
| MW: | 111.1 D |
ab 99,00 €
A-943931 (hydrochloride hydrate)
Artikelnummer: Cay34554-1
A-943931 is a histamine H4 receptor antagonist (Ki = 3.8 nM). In vivo, A-943931 inhibits scratching induced by clobenpropit (Cay-10011126) in mice (ED50 = 26 µmoles/kg, i.p.).Formal Name: 4-[(3R)-3-amino-1-pyrrolidinyl]-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine, dihydrochloride, hydrate. Molecular...
| Schlagworte: | 4-[(3R)-3-amino-1-pyrrolidinyl]-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine, dihydrochloride, hydrate |
| Anwendung: | Histamine H4 receptor antagonist |
| MW: | 368.3 D |
ab 44,00 €