Zu "K04151" wurden 63 Artikel gefunden!
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Irdabisant
Artikelnummer: TGM-T32191-100mg
Description: Irdabisant (CEP-26401) (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant antagonist/inverse agonist of histamine H3 receptor (H3R) (rat H3R Ki= 7.2 nM, human H3R Ki= 2.0 nM). Irdabisant exhibits relatively low inhibitory activity against hERG current (IC50= 13.8 µM)....
| Schlagworte: | CEP 26401, CEP-26401, CEP26401 |
| Anwendung: | Targets histamine receptor H3 (HRH3) |
| CAS | 1005402-19-6 |
| MW: | 313.39 D |
ab 54,00 €
Cipralisant maleate
Artikelnummer: TGM-T27022-25mg
Description: Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist. Target: Others. Smiles: OC(=O)\C=C/C(O)=O.CC(C)(C)CCC#C[C@@H]1C[C@H]1c1cnc[nH]1. References: Dent G. PNU-142731A Pharmacia. Curr Opin Investig Drugs. 2000 Dec,1(4):449-51. Review. PubMed PMID: 11249698.
| Schlagworte: | GT2331, GT 2331, Cipralisant maleate. trade name Perceptin, GT-2331 |
| Anwendung: | Targets histamine receptor H3 (HRH3) |
| CAS | 223420-20-0 |
| MW: | 332.39 D |
ab 1.971,00 €
JNJ-10181457 (hydrochloride)
Artikelnummer: TGM-T37220-1mg
Description: JNJ-10181457 (hydrochloride) is a non-imidazole H3 receptor antagonist that is brain-penetrating and selective, increasing NE and acetylcholine concentrations within the rat frontal cortex. Can be used for neurological-related research. Target: Others. Smiles: N1(CCCCC1)CCC#CC2=CC=CC(CN3CCOCC3)=C2.Cl.Cl
| Anwendung: | H3 Receptor antagonist |
| CAS | 544707-20-2 |
| MW: | 385.37 D |
ab 77,00 €
Thioperamide maleate
Artikelnummer: TGM-T41247-10mg
Description: Thioperamide maleate (MR-12842 maleate) is an effective and selective H3 receptor antagonist (Ki = 4.3 nM) that inhibits [3H]histamine synthesis (Ki = 31 nM). Target: Histamine Receptor. Smiles: OC(=O)\C=C/C(O)=O.S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1. References: Na Wang, et al. Histamine H3 Receptor...
| Schlagworte: | MR-12842 maleate |
| Anwendung: | Histamine H3 receptor antagonist |
| CAS | 148440-81-7 |
| MW: | 408.52 D |
ab 37,00 €
Irdabisant hydrochloride
Artikelnummer: TGM-T61197-100mg
Description: Irdabisant hydrochloride (CEP-26401) is a selective, orally active, and blood-brain barrier penetrating histamine H3 receptor (H3R) inverse agonist, demonstrating high affinity with K*i values of 7.2 nM and 2.0 nM for rat and human H3R, respectively. Exhibiting relatively low hERG current inhibitory...
| Anwendung: | Targets histamine receptor H3 (HRH3) |
| CAS | 1005398-61-7 |
| MW: | 349.86 D |
ab 1.520,00 €
Pitolisant hydrochloride
Artikelnummer: TGM-T7176-100mg
Description: Pitolisant hydrochloride (Ciproxidine) is a potent and selective inverse agonist of the histamine H3 receptor(Ki : 0.16 nM). Target: Histamine Receptor. Smiles: Cl.Clc1ccc(CCCOCCCN2CCCCC2)cc1. References: Kotanska Magdalena, Kuder K J , Szczepanska Katarzyna, et al. The histamine H3 receptor inverse...
| Schlagworte: | Ciproxidine, BF 2649 |
| Anwendung: | Targets histamine receptor H3 (HRH3) |
| CAS | 903576-44-3 |
| MW: | 332.31 D |
ab 43,00 €
Clobenpropit dihydrobromide
Artikelnummer: TGM-T8439-100mg
Description: Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07). Target: Apoptosis, Histamine Receptor. Smiles: Br.Br.Clc1ccc(CNC(=N)SCCCc2cnc[nH]2)cc1. References: Mena-Avila E, et al. Clobenpropit, a histamine H3 receptor antagonist/inverse...
| Anwendung: | Histamine H3 receptor antagonist |
| CAS | 145231-35-2 |
| MW: | 470.7 D |
ab 40,00 €
Bavisant
Artikelnummer: TGM-TQ0046-100mg
Description: Bavisant (JNJ-31001074) is a selective and orally active Human H3 receptor antagonist. Bavisant can be used in research on mechanisms of action, involving wakefulness and cognition and the treatment for ADHD. Target: Histamine Receptor. Smiles: C(=O)(N1CCN(CC1)C2CC2)C3=CC=C(CN4CCOCC4)C=C3. References:...
| Schlagworte: | JNJ-31001074 |
| Anwendung: | Targets histamine receptor H3 (HRH3) |
| CAS | 929622-08-2 |
| MW: | 329.44 D |
ab 37,00 €
GSK189254A
Artikelnummer: TGM-TQ0066-100mg
Description: GSK189254A (GSK189254) is a potent and specific histamine H3 receptor antagonist (pKi values: 9.59-9.90 and 8.51-9.17 for human and rat H3). Target: Histamine Receptor. Smiles: CNC(=O)c1ccc(Oc2ccc3CCN(CCc3c2)C2CCC2)nc1. References: Medhurst AD, et al. GSK189254, a novel H3 receptor antagonist that binds...
| Schlagworte: | GSK189254 |
| Anwendung: | Histamine H3 receptor antagonist |
| CAS | 720690-73-3 |
| MW: | 351.44 D |
ab 48,00 €
Pitolisant
Artikelnummer: TGM-T60636-100mg
Description: Pitolisant is a potent and selective nonimidazole inverse agonist that targets the recombinant human histamine H3 receptor, with a Ki of 0.16 nM. Target: Histamine Receptor. Smiles: Clc1ccc(CCCOCCCN2CCCCC2)cc1. References: Ligneau X, et al. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine,...
| Schlagworte: | Tiprolisant, BF-2.649, BF-2649 |
| Anwendung: | Targets histamine receptor H3 (HRH3) |
| CAS | 362665-56-3 |
| MW: | 295.85 D |
ab 42,00 €
Iodophenpropit dihydrobromide
Artikelnummer: TGM-T15590-10mg
Description: Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, selective, and of high affinity (KD: 0.32 nM). Target: Histamine Receptor. Smiles: Br.Ic1ccc(CCNC(=N)SCCCc2cnc[nH]2)cc1. References: Jansen FP,...
| Anwendung: | Histamine H3 receptor antagonist |
| CAS | 145196-87-8 |
| MW: | 495.22 D |
ab 295,00 €
Conessine
Artikelnummer: TGM-T20712-100mg
Description: Conessine (Conessinum), a steroidal alkaloid isolated from Holarrhena floribunda, interacts with the histamine H3 receptor and has anti-malarial activity. Target: Histamine Receptor. Smiles: [H][C@]12CC[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]13CN(C)[C@H]2C)N(C)C. References: Kim H,...
| Schlagworte: | Conessinum, Wrightine, Roquessine, Neriine, Konessin |
| Anwendung: | Allergy/Asthma studies |
| CAS | 546-06-5 |
| MW: | 356.59 D |
ab 40,00 €