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Zu "K04147" wurden 31 Artikel gefunden!
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Artikelnummer: Cay37586-10
L-745,870 is a dopamine D4 receptor antagonist (Ki = 0.43 nM). It is selective for dopamine D4 receptors over dopamine D2 and D3 receptors (Kis = 960 and 2,300 nM, respectively). It is also selective for dopamine D4 receptors over alpha2A-, alpha2B-, and alpha2C-adrenergic receptors (IC50s = 0.00043, 0.16, 0.17, and...
Schlagworte: | 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine, trihydrochloride |
Anwendung: | Dopamine D4 receptor antagonist |
CAS | 866021-03-6 |
MW: | 472.7 D |
ab 88,00 €
Artikelnummer: LKT-O4400.1
Olanzapine is an atypical antipsychotic. Olanzapine had high affinity for dopamine D1, D2, D4, serotonin (5HT)2A, 5HT2C, 5HT3, alpha 1-adrenergic, histamine H1, and five muscarinic receptor subtypes.
Schlagworte: | 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine |
CAS | 132539-06-1 |
MW: | 312.43 D |
ab 135,00 €
Artikelnummer: Cay11981-5
(S)-Pramipexole is a dopamine D2S, D2L, D3, and D4 receptor agonist (EC50s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [35S]GTPgammaS binding assay). It is also a partial agonist of alpha2A-adrenergic receptors (alpha2A-ARs, EC50 = 3,548.13 nM). (S)-Pramipexole is selective for dopamine D2-4 receptors...
Schlagworte: | (-)-Pramipexole, (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine, dihydrochloride |
Anwendung: | Galphai agonist |
CAS | 104632-25-9 |
MW: | 284.2 D |
ab 43,00 €
Artikelnummer: Cay28937-5
N,N-Dipropyldopamine is a dopamine receptor agonist. It decreases dihydrophenylalanine (DOPA) levels in the limbic forebrain and striatum of reserpinized rats (ED50s = 25 and 20 µmol/kg, respectively), as well as reduces homovanillic acid (HVA, Cay-27307) levels in rat striatum when administered at a dose of 80...
Schlagworte: | 4-[2-(dipropylamino)ethyl]-1,2-benzenediol, monohydrobromide |
Anwendung: | Dopamine receptor agonist |
CAS | 65273-66-7 |
MW: | 318.2 D |
ab 66,00 €
Artikelnummer: ARG55202.100
Protein function: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating...
Schlagworte: | Anti-DRD4, Anti-Dopamine D4 receptor, Anti-D(4) dopamine receptor, Anti-D(2C) dopamine receptor |
Anwendung: | WB, IHC (paraffin) |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse |
576,00 €
Artikelnummer: DIY0933GP-004
The Guinea Pig IL-8 Do-It-Yourself ELISA contains capture antibody, standard, and detection antibody for development of a Guinea Pig IL-8 ELISA. The antibodies have been determined to function in an ELISA with the standard provided. Optimal buffers, concentrations, incubation times, incubation temperatures, and...
Schlagworte: | Drd4, Dopamine D4 receptor, D(4) dopamine receptor, D(2C) dopamine receptor |
Anwendung: | ELISA |
Spezies-Reaktivität: | guinea pig |
ab 1.056,00 €
Artikelnummer: Cay17223-1
RBI 257 is a potent dopamine D4 receptor antagonist (Ki = 0.3 nM) that is selective over D2L, D3, D2-like, and D1 receptors by 1,721-, 439-, 1,336-, and 8,576-fold, respectively.Formal Name: N-[1-[(4-iodophenyl)methyl]-4-piperidinyl]-N-methyl-3-(1-methylethoxy)-2-pyridinamine (2Z)-2-butenedioate. CAS Number:...
Schlagworte: | N-[1-[(4-iodophenyl)methyl]-4-piperidinyl]-N-methyl-3-(1-methylethoxy)-2-pyridinamine (2Z)-2-butenedioate |
Anwendung: | D4 receptor antagonist |
CAS | 911378-38-6 |
MW: | 581.4 D |
ab 92,00 €
Artikelnummer: E-AB-12360.120
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic...
Schlagworte: | Anti-DRD4, Anti-Dopamine D4 receptor, Anti-D(4) dopamine receptor, Anti-D(2C) dopamine receptor, DRD4 Polyclonal Antibody |
Anwendung: | WB, IHC, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 71,00 €
Artikelnummer: Cay18234-50
Pramipexole (Cay-11981) is an agonist of dopamine receptors that has applications in Parkinson's disease and other disorders. Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine receptor-dependent activity resulting from the (S) form. (R)-Pramipexole is an enantiomer of...
Schlagworte: | (+)-Pramipexole, Dexpramipexole, KNS 760704, SND 919CL2X, 4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine,... |
Anwendung: | Dopamine receptor agonist control |
CAS | 104632-27-1 |
MW: | 284.2 D |
ab 88,00 €
Artikelnummer: Cay21376-50
Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals. It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively). Nemonapride also binds sigma 1...
Schlagworte: | YM-09151-2, rel-5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-benzamide |
Anwendung: | Dopamine D2/D3/D4-receptor antagonist |
CAS | 75272-39-8 |
MW: | 387.9 D |
ab 60,00 €
Artikelnummer: Cay11983-1
Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as alpha1- and alpha2-adrenergic receptors (Kis > 2,000 nM). Its safety profile in rat studies is improved in comparison to classical...
Schlagworte: | PNU 101387, U-101387, 4-[4-[2-[(1S)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]-benzenesulfonamide |
Anwendung: | Dopamine D4 DRD4 antagonist |
CAS | 170858-33-0 |
MW: | 401.5 D |
ab 60,00 €
Artikelnummer: Cay23447-5
Fluoroclebopride is a benzamide analog that is used in positron emission tomography (PET) applications. It binds reversibly to dopamine receptors (Kis = 0.95, 5.7, 5.46, and 144 nM for D2-like, D2(long), D3, and D4 receptors, respectively, in radioligand binding assays). It is selective for these receptors over D1,...
Schlagworte: | 4-amino-5-chloro-N-[1-[(4-fluorophenyl)methyl]-4-piperidinyl]-2-methoxy-benzamide |
Anwendung: | PET, Dopamine receptor binding |
CAS | 154540-49-5 |
MW: | 391.9 D |
ab 50,00 €