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Zu "K04139" wurden 63 Artikel gefunden!
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Artikelnummer: Cay36693-25
Romifidine is an alpha2-adrenergic receptor (alpha2-AR) agonist. Epidural administration of romifidine (50 µg/kg) induces antinociception and sedation in donkeys. It also induces bradycardia in horses when administered at doses ranging from 0.04 to 0.12 mg/kg. Formulations containing romifidine have been used as...
Schlagworte: | STH 2130, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride |
Anwendung: | Alpha2-AR agonist |
CAS | 65896-14-2 |
MW: | 294.6 D |
ab 93,00 €
Artikelnummer: Cay39544-10
Dexmedetomidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs). It selectively binds to alpha2-ARs over alpha1-ARs (Kis = 0.015 and 5 nM, respectively). In vivo, dexmedetomidine (50 µg/kg) prevents increases in cardiac troponin I (CTnI), a marker of myocardial injury, as well as reduces myocardial...
Schlagworte: | MPV 1440, 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole |
Anwendung: | Alpha2-AR agonist, sedative-hypnotic |
CAS | 113775-47-6 |
MW: | 200.3 D |
ab 53,00 €
Artikelnummer: NSJ-F54979-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from...
Schlagworte: | Anti-ADRA2B, Anti-ADRA2L1, Anti-Alpha-2BAR, Anti-Alpha-2B adrenoceptor, Anti-Alpha-2B adrenoreceptor, Anti-Alpha-2B... |
Anwendung: | WB, IF, FC, IHC (paraffin) |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 326,00 €
Artikelnummer: Cay14113-10
Xylazine is an agonist of alpha2-adrenergic receptors (Ki = 194 nM). It is an analog of clonidine, an alpha2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard...
Schlagworte: | N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine |
Anwendung: | alpha2 adrenergic receptor agonist |
CAS | 7361-61-7 |
MW: | 220.3 D |
ab 52,00 €
Artikelnummer: Cay36692-500
Xylazine is an agonist of alpha2-adrenergic receptors (Ki = 194 nM). It is an analog of clonidine, an alpha2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard...
Schlagworte: | BAY-Va 1470, N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine, monohydrochloride |
Anwendung: | Alpha2-adrenergic receptors agonist |
CAS | 23076-35-9 |
MW: | 256.8 D |
ab 35,00 €
Artikelnummer: Cay23993-10
Levonordefrin is the (-)-enantiomer of nordefrin, a synthetic derivative of norepinephrine (Cay-16673), that acts as a vasoconstrictor. Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer. It...
Schlagworte: | (-)-3,4-dihydroxy Norephedrine, (-)-alpha-methyl Noradrenaline, Corbadrine,... |
Anwendung: | Vasoconstrictor, alpha2-Adrenergic receptor agonist |
CAS | 829-74-3 |
MW: | 183.2 D |
ab 84,00 €
Artikelnummer: Cay16454-5
Medetomidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Ki = 1.08 nM). It is selective for alpha2-ARs over alpha1-ARs (Ki = 1,750 nM). Medetomidine induces sedation in dogs. Formulations containing medetomidine have been used as sedatives in veterinary medicine. This product is also available as an...
Schlagworte: | Domitor(R), MPV 785, 5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, monohydrochloride |
Anwendung: | alpha2-adrenergic receptor agonist |
CAS | 86347-15-1 |
MW: | 236.7 D |
ab 84,00 €
Artikelnummer: Cay19869-1
Yohimbine is a natural alkaloid that has highest affinity for alpha2-adrenergic receptors (pKis = 8.2, 8.7, and 9.6 for human alpha2A, alpha2B, and alpha2C, respectively), with antagonist activity at these receptors. It less potently antagonizes serotonin 5-HT1 receptors (pKis = 7.3, 6.8, and 7.6 for human HT1A,...
Schlagworte: | NIH 9689, NSC 19509, Yohimbe, 17alpha-hydroxy-yohimban-16alpha-carboxylic acid, methyl ester, monohydrochloride |
Anwendung: | Alpha-2A/B/C adrenergic receptor antagonist |
CAS | 65-19-0 |
MW: | 390.9 D |
ab 43,00 €
Artikelnummer: Cay25639-10
Moxonidine is an imidazoline 1 (I1) receptor agonist (Ki = 56 nM in a radioligand binding assay). It is also an agonist of the alpha2A-adrenergic receptor (alpha2A-AR, Ki = 150 nM in a radioligand binding assay). It is selective for I1 and alpha2A-AR receptors over alpha1-, alpha2B, and alpha2C-ARs (Kis = >30,000,...
Schlagworte: | LY326869, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine |
Anwendung: | Centrally-acting antiadrenergic |
CAS | 75438-57-2 |
MW: | 241.7 D |
ab 125,00 €
Artikelnummer: Cay17295-5
Fendiline is an alpha2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects. Fendiline has recently been reported to inhibit K-Ras plasma membrane localization (IC50 = 9.64 µM), which prevents K-Ras signal transduction and...
Schlagworte: | gamma-phenyl-N-(1-phenylethyl)-benzenepropanamine, monohydrochloride |
Anwendung: | alpha2-adrenergic receptor antagonist, L-type calcium channel blocker |
CAS | 13636-18-5 |
MW: | 351.9 D |
ab 46,00 €
Artikelnummer: Cay16988-10
Rilmenidine is an antihypertensive agent. It binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki = 6.1 nM), as well as alpha2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki = 87 nM). Rilmenidine induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25...
Schlagworte: | Oxaminozoline, S 3341, N-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine, 2E-butenedioate (2:1) |
Anwendung: | alpha2-adrenergic receptor agonist, nischarin agonist |
CAS | 207572-68-7 |
MW: | 238.3 D |
ab 54,00 €
Artikelnummer: Cay15596-250
Rauwolscine is a natural alkaloid that acts as a selective and reversible alpha2-adrenergic receptor antagonist (Ki = 12 nM). It is a stereoisomer of yohimbine, which potently antagonizes both alpha1- and alpha2-adrenergic receptors. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki...
Schlagworte: | Isoyohimbine, NSC 407307, alpha-Yohimbine, (16beta,17alpha,20alpha)-17-hydroxy-yohimban-16-carboxylic acid, methyl ester,... |
Anwendung: | Selective, reversible alpha2-adrenergic receptor antagonist |
CAS | 6211-32-1 |
MW: | 390.9 D |
ab 50,00 €