Zu "K04132" wurden 30 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Metixene (hydrochloride hydrate)
Artikelnummer: Cay39825-5
Metixene is an antagonist of muscarinic acetylcholine receptors (mAChRs, Ki = 15 nM for the rat receptor). It also inhibits bovine acetylcholinesterase (AChE) by 43% when used at the concentration 10 µM and butyrylcholinesterase (BChE, IC50 = 1.6 µM for the horse enzyme) in cell-free assays. Metixene reduces the...
| Schlagworte: | Methixine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-piperidine, monohydrochloride, monohydrate |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 7081-40-5 |
| MW: | 363.9 D |
ab 34,00 €
Trospium (chloride)
Artikelnummer: Cay21279-50
Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively). Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.Formal Name:...
| Schlagworte: | Relaspium,... |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 10405-02-4 |
| MW: | 428 D |
ab 43,00 €
Scopolamine N-butylbromide
Artikelnummer: LKT-S1058.1
An antispasmodic agent.
| Schlagworte: | Butylscopolamine bromide |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 149-64-4 |
| MW: | 440,38 D |
ab 94,00 €
Aclidinium (bromide)
Artikelnummer: Cay20699-5
Aclidinium is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 0.1, 0.14, 0.14, 0.21, and 0.16 for the M1-M5 receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at a concentration of 0.1 µM. Aclidinium reduces bronchoconstriction induced by ACh...
| Schlagworte: | LAS 34273, LAS-W 330, (3R)-3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane,... |
| Anwendung: | mAChR antagonist |
| CAS | 320345-99-1 |
| MW: | 564.6 D |
ab 43,00 €
Bethanechol (chloride)
Artikelnummer: Cay23830-5
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Cay-15592) in isolated...
| Schlagworte: | (±)-Bethanechol, Carbamyl-beta-methylcholine chloride, NSC 30783, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium,... |
| Anwendung: | Muscarinic acetylcholine receptor agonist |
| CAS | 590-63-6 |
| MW: | 196.7 D |
ab 50,00 €
Oxybutynin (hydrochloride)
Artikelnummer: Cay23825-5
Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively). It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol, Cay-14486) in bladder smooth muscle and submandibular gland cells isolated from...
| Schlagworte: | MJ4309-1, 4-(diethylamino)-2-butyn-1-yl ester alpha-cyclohexyl-alpha-hydroxy-benzeneacetic acid, monohydrochloride |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 1508-65-2 |
| MW: | 394 D |
ab 98,00 €
Cyclopentolate (hydrochloride)
Artikelnummer: Cay23944-5
Cyclopentolate is an antagonist of muscarinic acetylcholine receptors (Kis = 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively). It inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (Kbs = 7.9, 15.8, and 12.5 nM,...
| Schlagworte: | (±)-Cyclopentolate, alpha-(1-hydroxycyclopentyl)--benzeneacetic acid, 2-(dimethylamino)ethyl ester, monohydrochloride |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 5870-29-1 |
| MW: | 327.9 D |
ab 60,00 €
Tropicamide
Artikelnummer: Cay16606-1
Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction.Tropicamide is a muscarinic acetylcholine receptor (mAChR) antagonist (pKi = 7.2 in...
| Schlagworte: | Ro 1-7683, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-benzeneacetamide |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 1508-75-4 |
| MW: | 284.4 D |
ab 43,00 €
Atropine
Artikelnummer: LKT-A7868.1
Atropine is a naturally occurring tropane alkaloid isolated from plants in the Solanaceae family. Atropine is an anticholinergic compound that also exhibits analgesic and antinociceptive activities. Atropine is a competitive inhibitor of muscarinic acetylcholine receptors (mAChRs) that is commonly used for...
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 51-55-8 |
| MW: | 289.37 D |
64,00 €
Tropicamide
Artikelnummer: LKT-T7158.1
A specific muscarinic (M4) antagonist.
| Anwendung: | Muscarinic (M4) antagonist |
| CAS | 1508-75-4 |
| MW: | 284,35 D |
ab 81,00 €
VU0467154
Artikelnummer: Cay25555-1
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor that potentiates acetylcholine responses in CHO cells expressing M4 receptors (EC50s = 17.7, 630, and 1,000 nM for rat, human, and cynomolgus monkey receptors, respectively). It is selective for M4 over M1-3 and M5 receptors and...
| Schlagworte: | 5-amino-3,4-dimethyl-N-[[4-[(trifluoromethyl)sulfonyl]phenyl]methyl]-thieno[2,3-c]pyridazine-6-carboxamide |
| Anwendung: | Muscarinic acetylcholine receptor M4 positive allosteric modulator |
| CAS | 1451993-15-9 |
| MW: | 444.5 D |
ab 80,00 €
AF-DX 384
Artikelnummer: Cay25638-1
AF-DX 384 is an antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis = 6.03 and 10 nM, respectively). It is selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively). AF-DX 384 increases acetylcholine release in the hippocampus and cortex of young and aged rats...
| Schlagworte: | N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide |
| Anwendung: | Muscarinic acetylcholine receptor M2 / M4 antagonist |
| CAS | 118290-26-9 |
| MW: | 478.6 D |
ab 44,00 €