Zu "K04132" wurden 39 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Emraclidine
Artikelnummer: TGM-T9694-100mg
Description: Emraclidine (CVL-231), a muscarinic M4 receptor positive allosteric modulator, is utilized in studies of neurological diseases. Target: AChR. Smiles: Cc1cc(C)c2CN(Cc2n1)C(=O)CC1CN(C1)c1ccnc(c1)C(F)(F)F. References: Lei Zhang, et al. 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and...
| Schlagworte: | CVL-231 |
| Anwendung: | Targets muscarinic acetylcholine receptor M4 (CHRM4) |
| CAS | 2170722-84-4 |
| MW: | 390.4 D |
ab 126,00 €
Iperoxo
Artikelnummer: TGM-T25538-100mg
Description: Iperoxo (Iperoxo iodide) is an agonist of Muscarinic AChR and can be used to probe activation-related conformational transitions of muscarinic receptors. Target: AChR. Smiles: [I-].C[N+](C)(C)CC#CCOC1=NOCC1. References: Jiménez-Rosés M, et al. Ligand-Triggered Structural Changes in the M(2) Muscarinic...
| Schlagworte: | Iperoxo iodide |
| Anwendung: | Muscarinic acetylcholine receptor CHRM2/CHRM4 agonist |
| CAS | 247079-84-1 |
| MW: | 324.16 D |
ab 46,00 €
LY2119620
Artikelnummer: TGM-T6575-100mg
Description: LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. Target: AChR. Smiles: CN1CCN(CC1)C(=O)COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl. References: Croy CH, et al. Mol Pharmacol. 2014, 86(1), 106-115.
| Anwendung: | Muscarinic acetylcholine receptor M2 / M4 positive allosteric modulator (PAM) |
| CAS | 886047-22-9 |
| MW: | 437.94 D |
ab 52,00 €
VU0152100
Artikelnummer: TGM-T17238-100mg
Description: VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM). Target: AChR. Smiles: COc1ccc(CNC(=O)c2sc3nc(C)cc(C)c3c2N)cc1. References: Brady AE, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced...
| Schlagworte: | VU152100 |
| Anwendung: | Muscarinic M4 receptor positive allosteric modulator |
| CAS | 409351-28-6 |
| MW: | 341.43 D |
ab 34,00 €
VU0467154
Artikelnummer: TGM-T17244-100mg
Description: VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (M4 mAChR). Target: AChR. Smiles: NC=1C=2C(SC1C(NCC3=CC=C(S(C(F)(F)F)(=O)=O)C=C3)=O)=NN=C(C)C2C. References: Bubser M, et al. Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced...
| Anwendung: | Muscarinic acetylcholine receptor M4 positive allosteric modulator |
| CAS | 1451993-15-9 |
| MW: | 444.45 D |
ab 41,00 €
Anti-CHRM4
Artikelnummer: CSB-PA003183.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-CHRM4, Anti-Muscarinic acetylcholine receptor M4, AChR antibody, ACM4_HUMAN antibody, Cholinergic receptor muscarinic... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Anti-CHRM4
Artikelnummer: CSB-PA205812.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CHRM4. Antigen Species: Human
| Schlagworte: | Anti-CHRM4, Anti-Muscarinic acetylcholine receptor M4, AChR antibody, ACM4_HUMAN antibody, Cholinergic receptor muscarinic... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
Metixene (hydrochloride hydrate)
Artikelnummer: Cay39825-5
Metixene is an antagonist of muscarinic acetylcholine receptors (mAChRs, Ki = 15 nM for the rat receptor). It also inhibits bovine acetylcholinesterase (AChE) by 43% when used at the concentration 10 µM and butyrylcholinesterase (BChE, IC50 = 1.6 µM for the horse enzyme) in cell-free assays. Metixene reduces the...
| Schlagworte: | Methixine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-piperidine, monohydrochloride, monohydrate |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 7081-40-5 |
| MW: | 363.9 D |
ab 34,00 €
Trospium (chloride)
Artikelnummer: Cay21279-50
Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively). Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.Formal Name:...
| Schlagworte: | Relaspium,... |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 10405-02-4 |
| MW: | 428 D |
ab 43,00 €
Scopolamine N-butylbromide
Artikelnummer: LKT-S1058.1
An antispasmodic agent.
| Schlagworte: | Butylscopolamine bromide |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 149-64-4 |
| MW: | 440,38 D |
ab 94,00 €
Aclidinium (bromide)
Artikelnummer: Cay20699-5
Aclidinium is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 0.1, 0.14, 0.14, 0.21, and 0.16 for the M1-M5 receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at a concentration of 0.1 µM. Aclidinium reduces bronchoconstriction induced by ACh...
| Schlagworte: | LAS 34273, LAS-W 330, (3R)-3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane,... |
| Anwendung: | mAChR antagonist |
| CAS | 320345-99-1 |
| MW: | 564.6 D |
ab 43,00 €
McNA343
Artikelnummer: Cay30961-10
McNA343 is a partial agonist of muscarinic acetylcholine receptors (Kis = 5, 1, 5, 0.2, and 7.6 µM for M1-5 receptors, respectively, in radioligand binding assays). It induces contraction of isolated human umbilical veins (EC50 = 1.23 µM), an effect that can be reversed by various M1 muscarinic receptor selective...
| Schlagworte: | 4-[[[(3-chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium, monochloride |
| Anwendung: | Muscarinic acetylcholine receptor partial agonist |
| CAS | 55-45-8 |
| MW: | 317.2 D |
ab 42,00 €