Zu "K04130" wurden 103 Artikel gefunden!
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Otilonium (bromide)
Artikelnummer: Cay29907-1
Otilonium is an inhibitor of L-type (IC50 = 2.3 µM) and T-type calcium channels (IC50s = 0.8, 1.1, and 0.4 µM for Cav3.1, Cav3.2, and Cav3.3, respectively). It is also an antagonist of muscarinic acetylcholine receptors (mAChRs, IC50s = 0.054, 0.4, 0.222, and 0.156 µM for M1, M2, M4, and M5 muscarinic receptors,...
| Schlagworte: | Octylonium, N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-ethanaminium, monobromide |
| Anwendung: | L-/ T-type calcium channel inhibitor, mAChR antagonist |
| CAS | 26095-59-0 |
| MW: | 563.6 D |
ab 136,00 €
Scopolamine (hydrobromide)
Artikelnummer: Cay14108-5
Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family. It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals. Scopolamine prevents motion sickness, nausea, and vomiting in animals.Formal Name:...
| Schlagworte: | Hyoscine, (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester... |
| Anwendung: | Analytical reference standard, tropane alkaloid, muscarinic receptor antagonist, antiemetic |
| CAS | 114-49-8 |
| MW: | 384.3 D |
ab 109,00 €
Arecaidine propargyl ester (hydrobromide)
Artikelnummer: TGM-T36241-10mg
Description: Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 µM, respectively). Arecaidine propargyl ester induces contractions...
| Anwendung: | Muscarinic M2 agonist |
| CAS | 116511-28-5 |
| MW: | 260.13 D |
ab 151,00 €
Dimethyl-W84 (dibromide)
Artikelnummer: TGM-T38111-5mg
Description: Dimethyl-W84 is a selective allosteric modulator of the M2 muscarinic acetylcholine receptor. It hinders the dissociation of the orthosteric antagonist N-methylscopolamine from the M2 receptor with an EC50 value of 3 nM. Target: Others. Smiles:...
| Schlagworte: | Dimethyl-W84 (dibromide) |
| Anwendung: | Selective allosteric M2 muscarinic acetylcholine receptor modulator |
| CAS | 402475-33-6 |
| MW: | 736.59 D |
345,00 €
Syn-Ake acetate
Artikelnummer: TGM-T7895-100mg
Description: Syn-Ake acetate (Dipeptide diaminobutyroyl benzylamide) is a muscarinic acetylcholine receptor antagonist. Target: AChR. Smiles: CC(O)=O.CC(O)=O.NCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CCN)C(=O)NCc1ccccc1. References: Balaev A N , Okhmanovich K A , Osipov V N . A shortened, protecting group free, synthesis of...
| Schlagworte: | Dipeptide diaminobutyroyl benzylamide |
| Anwendung: | Biomimetic peptide, muscarinic acetylcholine receptor antagonist |
| CAS | 823202-99-9 |
| MW: | 495.58 D |
ab 56,00 €
CHRM2 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01715-100ug
Description: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes...
| Schlagworte: | Muscarinic acetylcholine receptor M2, CHRM2 |
| MW: | 23.4 kD |
ab 278,00 €
Pilocarpine nitrate
Artikelnummer: TGM-T1231-100mg
Description: Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. Target: AChR. Smiles: O[N+]([O-])=O.CC[C@H]1[C@@H](Cc2cncn2C)COC1=O. References: Sykes DA, et al. Mol Pharmacol. 2009 Sep,76(3):543-51.
| Schlagworte: | Pilofrin, Pilagan |
| Anwendung: | Targets muscarinic acetylcholine receptor M3 (CHRM3) |
| CAS | 148-72-1 |
| MW: | 271.27 D |
41,00 €
Otenzepad
Artikelnummer: TGM-T16411-100mg
Description: Otenzepad (AF-DX 116) is a selective M2 mAChR antagonist with IC50 values of 386 nM in rat heart and 640 nM in rabbit peripheral lung. Target: AChR. Smiles: CCN(CC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12. References: Packard MG, et al. Post-training injection of the acetylcholine M2 receptor antagonist...
| Schlagworte: | AF-DX 116 |
| Anwendung: | Muscarinic acetylcholine receptor M2 antagonist |
| CAS | 102394-31-0 |
| MW: | 421.54 D |
ab 39,00 €
Trospium chloride
Artikelnummer: TGM-T1472-100mg
Description: Trospium chloride (Spasmex) is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium chloride has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury. Target: AChR. Smiles:...
| Schlagworte: | Sanctura, Spasmex |
| Anwendung: | Targets muscarinic acetylcholine receptor M2 (CHRM2) |
| CAS | 10405-02-4 |
| MW: | 427.964 D |
ab 46,00 €
Fesoterodine fumarate
Artikelnummer: TGM-T1475-100mg
Description: Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo into its active metabolite 5-hydroxymethyl tolterodine, which binds and inhibits...
| Schlagworte: | SPM 907, Toviaz |
| Anwendung: | Targets muscarinic acetylcholine receptor M3 (CHRM3) |
| CAS | 286930-03-8 |
| MW: | 527.65 D |
ab 47,00 €
Muscarinic acetylcholine receptor M2 (CHRM2), partial,...
Artikelnummer: CSB-EP005382HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 210-387aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: SRASKSRIKK DKKEPVANQD PVSPSLVQGR IVKPNNNNMP SSDDGLEHNK IQNGKAPRDP VTENCVQGEE KESSNDSTSV SAVASNMRDD EITQDENTVS TSLGHSKDEN SKQTCIRIGT KTPKSDSCTP TNTTVEVVGS...
| Schlagworte: | CHRM2, Muscarinic acetylcholine receptor M2, Recombinant Human Muscarinic acetylcholine receptor M2 (CHRM2), partial |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 23.4 kD |
ab 283,00 €
Human CHRM2 Protein, hFc Tag
Artikelnummer: DIM-PME101282.10
Recombinant Human CHRM2 Protein with C-terminal human Fc tag. CHRM2(Met1-Glu22) hFc(Glu99-Ala330), Protein function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the...
| Schlagworte: | HM2 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 28.6 kD |
ab 98,00 €