Zu "K03875" wurden 52 Artikel gefunden!
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Anti-SKP2
Artikelnummer: ABS-KC-3927.100
Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes...
| Schlagworte: | Anti-S-phase kinase-associated protein 2, Anti-Cyclin-A/CDK2-associated protein p45, Anti-F-box protein Skp2,... |
| Anwendung: | IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
SZL P1-41
Artikelnummer: TGM-T3317-100mg
Description: SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. It suppresses the survival of Y...
| Anwendung: | Skp2 (FBXL1) inhibitor |
| CAS | 222716-34-9 |
| MW: | 420.52 D |
ab 31,00 €
Skp2 Inhibitor C1
Artikelnummer: TGM-T4253-100mg
Description: Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation. Target: E1/E2/E3 Enzyme, Others. Smiles: OC(=O)COc1ccc(Br)cc1\C=C1/SC(=S)N(Cc2cccnc2)C1=O. References: Wu L, et al. Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem...
| Schlagworte: | SKPin C1 |
| Anwendung: | Skp2 inhibitor |
| CAS | 432001-69-9 |
| MW: | 465.34 D |
ab 37,00 €
Skp2 inhibitor 2
Artikelnummer: TGM-T78194-50mg
Description: Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 µM against Skp2-Cks1. This compound targets Skp2, a component of cullin-RING ligases that recruits and ubiquitinates substrates, playing roles in both proteolytic and...
| Anwendung: | Skp2 inhibitor |
| CAS | 2760612-77-7 |
| MW: | 428.57 D |
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SKP2 Protein, Human, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-02131-100ug
Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes...
| Schlagworte: | Cyclin-A/CDK2-associated protein p45, p45skp2, F-box/LRR-repeat protein 1, F-box protein Skp2, SKP2, S-phase... |
| MW: | 63.8 kD |
ab 198,00 €
SMIP004
Artikelnummer: TGM-T16901-10mg
Description: SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells. Target: Apoptosis, E1/E2/E3 Enzyme, Others. Smiles: CCCCC1=CC(C)=C(NC(C)=O)C=C1. References: Li C, et al. SKP2 promotes breast cancer tumorigenesis and radiation tolerance...
| Anwendung: | SKP2 inhibitor |
| CAS | 143360-00-3 |
| MW: | 205.3 D |
ab 81,00 €
S-phase kinase-associated protein 2 (SKP2), human,...
Artikelnummer: CSB-EP613392HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-424aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: MHRKHLQEIP DLSSNVATSF TWGWDSSKTS ELLSGMGVSA LEKEEPDSEN IPQELLSNLG HPESPPRKRL KSKGSDKDFV IVRRPKLNRE NFPGVSWDSL PDELLLGIFS CLCLPELLKV SGVCKRWYRL...
| Schlagworte: | SKP2, FBXL1, p45skp2, F-box protein Skp2, F-box/LRR-repeat protein 1, S-phase kinase-associated protein 2,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 63.8 kD |
ab 219,00 €
Anti-SKP2
Artikelnummer: CSB-PA004098.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-SKP2, Anti-FBXL1, Anti-p45skp2, Anti-F-box protein Skp2, Anti-F-box/LRR-repeat protein 1, Anti-S-phase... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 126,00 €
SMIP004
Artikelnummer: Cay40645-1
SMIP004 is an inhibitor of the E3 ubiquitin ligase S-phase kinase-associated protein 2 (SKP2). It reduces the levels of SKP2 and induces the accumulation of p27Kip1 and p21Cip21, ubiquitination targets of SKP2, in LNCaP-S14 human prostate cancer cells overexpressing SKP2 when used at a concentration of 40 µM....
| Schlagworte: | SKP2 E3 Ligase Inhibitor II, S-phase Kinase-associated Protein 2 E3 Ligase Inhibitor 11, N-(4-butyl-2-methylphenyl)-acetamide |
| Anwendung: | SKP2 inhibitor |
| CAS | 143360-00-3 |
| MW: | 205.3 D |
ab 35,00 €
SKPin C1
Artikelnummer: Cay26141-5
SKPin C1 is an inhibitor of Skp1-Cullin1-F-box (SCF) family protein Skp2-mediated p27 degradation. It binds to Skp2 at the Cdc kinase subunit 1 (Cks1) interaction interface and blocks ubiquitylation of p27 in a Cks1-dependent manner in vitro when used at a concentration of 50 µM. SKPin C1 increases nuclear...
| Schlagworte: | 2-[4-bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]-acetic acid |
| Anwendung: | Skp2-mediated p27 degradation inhibitor |
| CAS | 432001-69-9 |
| MW: | 465.3 D |
ab 112,00 €
Anti-SKP2
Artikelnummer: A302-436A
Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes...
| Schlagworte: | Anti-SKP2, Anti-FBXL1, Anti-p45skp2, Anti-F-box protein Skp2, Anti-F-box/LRR-repeat protein 1, Anti-S-phase... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
Anti-SKP2
Artikelnummer: A302-437A
Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes...
| Schlagworte: | Anti-SKP2, Anti-FBXL1, Anti-p45skp2, Anti-F-box protein Skp2, Anti-F-box/LRR-repeat protein 1, Anti-S-phase... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €