Zu "K03176" wurden 140 Artikel gefunden!
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Entrectinib
Artikelnummer: TGM-T3678-100mg
Description: Entrectinib (RXDX-101) is a Trk, ROS1, and ALK inhibitor that inhibits TrkA, TrkB, TrkC, ROS1, and ALK (IC50=1/3/5/12/7 nM) with oral activity and blood-brain-barrier penetration. Entrectinib exhibits both antitumor and CNS activity. Target: ALK, ROS Kinase, ROS, Autophagy, Trk receptor. Smiles:...
| Schlagworte: | RXDX-101, NMS-E628 |
| Anwendung: | Targets neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1] (NTRK1, TRKA) |
| CAS | 1108743-60-7 |
| MW: | 560.64 D |
ab 37,00 €
Repotrectinib
Artikelnummer: TGM-T4071-100mg
Description: Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 values of 1.01 nM for WT ALK, 5.3 nM for SRC, 1.08 nM for ALK L1196M, and 1.26 nM for ALK G1202R. Target: ALK, ROS, ROS Kinase, Src, Trk receptor. Smiles: C[C@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23. References: Dayong...
| Schlagworte: | TPX-0005, TPX0005, TPX 0005 |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase ROS [EC:2.7.10.1] (ROS1) |
| CAS | 1802220-02-5 |
| MW: | 355.37 D |
ab 45,00 €
Belizatinib
Artikelnummer: TGM-T4257-100mg
Description: Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC. Target: Trk receptor, ALK. Smiles: CC(C)NC(=O)[C@H]1CC[C@H](CC1)n1c(NC(=O)c2ccc(F)cc2)nc2ccc(CN3CCC(CC3)C(C)(C)O)cc12. References: Sullivan I, et al. ALK inhibitors...
| Schlagworte: | TSR-011 |
| Anwendung: | ALK inhibitor, TrkA/TrkB/TrkC inhibitor |
| CAS | 1357920-84-3 |
| MW: | 577.73 D |
ab 37,00 €
TrkA Protein, Human, Recombinant (His & hFc)
Artikelnummer: TGM-TMPY-01083-100ug
Description: TrkA Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 66 kDa and the accession number is P04629-1.
| Schlagworte: | TRKA, p140-TrkA, TRK, TRK1, Trk-A, MTC, neurotrophic tyrosine kinase, receptor, type 1 |
| MW: | 66 kD |
599,00 €
TrkA Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-01084-100ug
Description: TrkA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is P04629-1.
| Schlagworte: | TRKA, TRK, TRK1, Trk-A, MTC, neurotrophic tyrosine kinase, receptor, type 1, p140-TrkA |
| MW: | 39.5 kD |
ab 292,00 €
TrkA Protein, Human, Recombinant (aa 33-417, His)
Artikelnummer: TGM-TMPK-00774-100ug
Description: TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signaling pathways, resulting in diverse biological effects.
| Schlagworte: | MTC, NTRK1, TRKA, Trk-A, TrkA I, TrkA-I, TRK, TrkAI |
| MW: | 43.00 kD |
ab 417,00 €
TrkA Protein, Human, Recombinant (aa 285-413, His)
Artikelnummer: TGM-TMPY-01759-100ug
Description: TrkA Protein, Human, Recombinant (aa 285-413, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 15.1 kDa and the accession number is P04629-1.
| Schlagworte: | TRK, p140-TrkA, neurotrophic tyrosine kinase, receptor, type 1, Trk-A, TRKA, MTC, TRK1 |
| MW: | 15.1 kD |
ab 599,00 €
TrkA Protein, Human, Recombinant (aa 194-413, His)
Artikelnummer: TGM-TMPY-01760-100ug
Description: TrkA Protein, Human, Recombinant (aa 194-413, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P04629-1.
| Schlagworte: | neurotrophic tyrosine kinase, receptor, type 1, MTC, p140-TrkA, Trk-A, TRKA, TRK1, TRK |
| MW: | 26 kD |
599,00 €
TrkA Protein, Mouse, Recombinant (hFc)
Artikelnummer: TGM-TMPY-03470-100ug
Description: TrkA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.2 kDa and the accession number is Q3UFB7.
| Schlagworte: | TrkA, C80751, Tkr, neurotrophic tyrosine kinase, receptor, type 1, trk |
| MW: | 69.2 kD |
599,00 €
TrkA Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPY-03536-100ug
Description: TrkA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is Q3UFB7.
| Schlagworte: | TrkA, neurotrophic tyrosine kinase, receptor, type 1, trk, C80751, Tkr |
| MW: | 43.7 kD |
ab 599,00 €
TrkA Protein, Rat, Recombinant (hFc)
Artikelnummer: TGM-TMPY-03560-100ug
Description: TrkA Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.2 kDa and the accession number is P35739.
| Schlagworte: | neurotrophic tyrosine kinase, receptor, type 1 |
| MW: | 69.2 kD |
599,00 €
TrkA Protein, Rat, Recombinant (His)
Artikelnummer: TGM-TMPY-04285-100ug
Description: TrkA Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is A6J617.
| Schlagworte: | neurotrophic tyrosine kinase, receptor, type 1 |
| MW: | 43.7 kD |
ab 599,00 €