Zu "K03163" wurden 102 Artikel gefunden!
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NEU
DNA topoisomerase 1 (TOP1), partial, human, recombinant
Artikelnummer: CSB-BP024056HU1.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 190-765aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: NKKKKPKKEE EQKWKWWEEE RYPEGIKWKF LEHKGPVFAP PYEPLPENVK FYYDGKVMKL SPKAEEVATF FAKMLDHEYT TKEIFRKNFF KDWRKEMTNE EKNIITNLSK...
| Schlagworte: | TOP1, DNA topoisomerase I, DNA topoisomerase 1, Recombinant Human DNA topoisomerase 1 (TOP1), partial |
| Anwendung: | Activity not tested |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 72.2 kD |
ab 474,00 €
NEU
DNA topoisomerase 1 (TOP1), partial, human, recombinant
Artikelnummer: CSB-BP024056HU1c7.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 190-765aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: NKKKKPKKEE EQKWKWWEEE RYPEGIKWKF LEHKGPVFAP PYEPLPENVK FYYDGKVMKL SPKAEEVATF FAKMLDHEYT TKEIFRKNFF KDWRKEMTNE EKNIITNLSK CDFTQMSQYF KAQTEARKQM...
| Schlagworte: | TOP1, DNA topoisomerase I, DNA topoisomerase 1, Recombinant Human DNA topoisomerase 1 (TOP1), partial |
| Anwendung: | Activity not tested |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 73.8 kD |
ab 474,00 €
NEU
Exatecan (mesylate)
Artikelnummer: Cay35452-5
Exatecan is a derivative of camptothecin (Cay-11694) and DNA topoisomerase I inhibitor (IC50 = 0.975 µg/ml). It inhibits cell growth in a panel of 32 breast, colon, stomach, and lung cancer cell lines (GI50s = 0.125-10.4 ng/ml). Exatecan (3.325-50 mg/kg) reduces tumor growth in an SC-6-JCK gastric adenocarcinoma...
| Schlagworte: | DX 8951f,... |
| Anwendung: | DNA topoisomerase I inhibitor |
| CAS | 169869-90-3 |
| MW: | 531.6 D |
34,00 €
Camptothecin
Artikelnummer: Cay11694-50
DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs...
| Schlagworte: | MAG-CPT, NSC 94600, (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Anwendung: | Topoisomerase inhibitor |
| CAS | 7689-03-4 |
| MW: | 348.4 D |
ab 35,00 €
SN-38-d3
Artikelnummer: Cay40133-1
SN-38-d3 is intended for use as an internal standard for the quantification of SN-38 (Cay-15632) by GC- or LC-MS. SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Cay-14180). It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase...
| Schlagworte: | 7-ethyl-10-hydroxy-20(S)-Camptothecin-d3, 7-Ethyl-10-Hydroxycamptothecin-d3,... |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, DNA topoisomerase I inhibitor |
| CAS | 718612-49-8 |
| MW: | 395.4 D |
909,00 €
Human TOP1 (Topoisomerase I) ELISA Kit
Artikelnummer: ELK-ELK3045.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TOP1. Next,...
| Schlagworte: | TOP1, DNA topoisomerase I, DNA topoisomerase 1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Rat TOP1 (Topoisomerase I) ELISA Kit
Artikelnummer: ELK-ELK7553.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat TOP1. Next,...
| Schlagworte: | Top1, DNA topoisomerase I, DNA topoisomerase 1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 365,00 €
Mouse TOP1 (Topoisomerase I) ELISA Kit
Artikelnummer: ELK-ELK7019.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TOP1. Next,...
| Schlagworte: | Top1, Top-1, DNA topoisomerase I, DNA topoisomerase 1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Topotecan (hydrochloride)
Artikelnummer: Cay14129-5
Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Cay-11694). Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay....
| Schlagworte: | NSC 609669, SKF 104864A,... |
| Anwendung: | Topoisomerase I inhibitor |
| CAS | 119413-54-6 |
| MW: | 457.9 D |
ab 42,00 €
SN-38
Artikelnummer: Cay15632-5
SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Cay-14180). It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase I-dependent DNA cleavage in a cell-free assay. It induces DNA single-strand breaks in HT-29 colorectal...
| Schlagworte: | 7-ethyl-10-hydroxy-20(S)-Camptothecin, 7-Ethyl-10-Hydroxycamptothecin, NK 012,... |
| Anwendung: | Potent DNA topoisomerase I inhibitor |
| CAS | 86639-52-3 |
| MW: | 392.4 D |
ab 66,00 €
Irinotecan (hydrochloride hydrate)
Artikelnummer: Cay14180-25
Irinotecan, a derivative of the alkaloid camptothecin (Cay-11694), functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1. Irinotecan demonstrates...
| Schlagworte: | [1,4'-bipiperidine]-1'-carboxylic acid,... |
| Anwendung: | Topoisomerase I inhibitor |
| CAS | 136572-09-3 |
| MW: | 677.2 D |
ab 66,00 €
Rebeccamycin
Artikelnummer: BVT-0139-C250
Antibiotic, Weak topoisomerase I (Topo I) inhibitor, Structurally similar to staurosporine, Does not show any inhibitory activity against protein kinases, Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells). Isolated from...
| Schlagworte: | NSC 359079, BRN 4732638 |
| Anwendung: | Topoisomerase I (Topo I) inhibitor |
| CAS | 93908-02-2 |
| MW: | 570,4 D |
ab 95,00 €