Zu "K03163" wurden 147 Artikel gefunden!
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Dxd
Artikelnummer: Cay41699-10
Dxd is a derivative of the DNA topoisomerase I inhibitor exatecan (Cay-35452) and a starting material that has been used in the synthesis of antibody-drug conjugates (ADCs). It has been used in the synthesis of ADCs targeting HER2 with anticancer activity in vitro and in vivo.Formal Name:...
| Schlagworte: | N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indol... |
| Anwendung: | Exatcan (DNA topoisomerase I inhibitor) derivative, ADC synthesis starting material |
| CAS | 1599440-33-1 |
| MW: | 493.5 D |
ab 90,00 €
Camptothecin
Artikelnummer: Cay11694-50
DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs...
| Schlagworte: | MAG-CPT, NSC 94600, (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Anwendung: | Topoisomerase inhibitor |
| CAS | 7689-03-4 |
| MW: | 348.4 D |
ab 36,00 €
Topotecan hydrochloride
Artikelnummer: TGM-T1174-100mg
Description: Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer. Target: Autophagy, Apoptosis, Topoisomerase. Smiles: Cl.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O. References: Caceres G, et al. Anticancer Drugs. 2003, 14(7), 569-574.
| Schlagworte: | NSC 609669, Nogitecan HCl, SKF 104864A, SKFS 104864A, NSC609699, Topotecan HCl |
| Anwendung: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| CAS | 119413-54-6 |
| MW: | 457.92 D |
ab 31,00 €
Top1 inhibitor 1
Artikelnummer: TGM-T13183-100mg
Description: Top1 inhibitor 1 is a potent inhibitor of human topoisomerase I (Top1)(IC50: 29 nM). Target: Others, ADC Cytotoxin. Smiles: N(CCCN1C=CN=C1)C=2C3=C(N=CC2C4=NN=CO4)C=CC(=C3)C5=CC=C(OC)C=C5. References: Kundu B, et al. Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1...
| Anwendung: | DNA topoisomerase I (Top1) inhibitor |
| CAS | 2302772-05-8 |
| MW: | 426.47 D |
ab 1.491,00 €
SN-38
Artikelnummer: TGM-T1703-100mg
Description: SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 µM). SN-38 has antitumor activity and induces autophagy. Target: Autophagy, Topoisomerase, DNA/RNA Synthesis, ADC Cytotoxin. Smiles:...
| Schlagworte: | NK012, SN 38 |
| Anwendung: | Topoisomerase I inhibitor |
| CAS | 86639-52-3 |
| MW: | 392.4 D |
ab 39,00 €
(±)-10-Hydroxycamptothecin
Artikelnummer: TGM-T1521-25mg
Description: (±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity....
| Schlagworte: | 10-Hydroxycamptothecin, Hydroxy Camptothecine |
| Anwendung: | DNA topoisomerase I inhibitor |
| CAS | 64439-81-2 |
| MW: | 364.35 D |
ab 56,00 €
Karenitecin
Artikelnummer: TGM-T14703-100mg
Description: Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity. Target: Topoisomerase. Smiles: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4c(CC[Si](C)(C)C)c3Cn1c2=O. References: Yin MB, et al. Characterization of protein kinase chk1 essential for the cell cycle checkpoint after...
| Schlagworte: | Cositecan, BNP 1350 |
| Anwendung: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| CAS | 203923-89-1 |
| MW: | 448.59 D |
ab 1.501,00 €
Edotecarin
Artikelnummer: TGM-T15200-100mg
Description: Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM). Target: Topoisomerase. Smiles: O=C1C2=C3C(N(C=4C3=CC=C(O)C4)[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)=C6C(=C2C(=O)N1NC(CO)CO)C=7C(N6)=CC(O)=CC7. References: Saif MW, et al. Edotecarin: a novel...
| Schlagworte: | J 107088, PF 804950 |
| Anwendung: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| CAS | 174402-32-5 |
| MW: | 608.55 D |
ab 2.227,00 €
Aclacinomycin A
Artikelnummer: TGM-T21502-1mg
Description: Aclacinomycin A (Aclarubicin) is a novel anthracycline antibiotic isolated from Streptomyces galilei with antitumor activity.Aclacinomycin A is an inhibitor of topoisomerases I and II and inhibits RNA activity.Aclacinomycin A has been used in the study of relapsed leukemia and advanced malignant...
| Schlagworte: | Aclarubicin |
| Anwendung: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| CAS | 57576-44-0 |
| MW: | 811.87 D |
292,00 €
(S)-10-Hydroxycamptothecin
Artikelnummer: TGM-T2764-100mg
Description: (S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor used as a clinical therapeutic agent against hepatoma. Target: Apoptosis, Topoisomerase. Smiles: O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(O)C4)=CC5=C1COC(=O)[C@@]5(CC)O. References: Ling YH, et al. Cancer Biochem Biophys, 1990, 11(1), 23-30.
| Schlagworte: | 10-Hydroxycamptothecin, 10-HCPT |
| Anwendung: | Topoisomerase I inhibitor |
| CAS | 19685-09-7 |
| MW: | 364.35 D |
ab 44,00 €
Reticulol
Artikelnummer: TGM-T28522-5mg
Description: Reticulol is an isocoumarin derivative produced by certain species of Streptomyces. Reticulol inhibits cAMP phosphodiesterase (IC50 = 41 µM). Recticulol (M.W. 222.2) exhibits a potent in vitro cytotoxicity against the human lung tumor cell line A427 and the mouse melanoma cell line B16F10. Target:...
| Anwendung: | Topoisomerase I (Topo I) inhibitor |
| CAS | 26246-41-3 |
| MW: | 222.19 D |
1.507,00 €
SW044248
Artikelnummer: TGM-T3181-100mg
Description: SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells. Target: Topoisomerase. Smiles: CCC(Sc1nnc2c3ccccc3n(CC)c2n1)C(=O)Nc1ccccc1OC. References: Zubovych IO, et al. Mol Y Ther. 2016 Jan,15(1):23-36.
| Anwendung: | DNA topoisomerase I inhibitor |
| CAS | 522650-83-5 |
| MW: | 421.52 D |
ab 37,00 €