Zu "K02861" wurden 90 Artikel gefunden!
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Necrostatin-5
Artikelnummer: TGM-T37558-10mg
Description: Necrostatin-5 (Nec-5) is a selective RIP1 kinase inhibitor and cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-alpha, with an EC50 of 240 nM. Target: Necroptosis, RIP kinase. Smiles: O=C1C=2C3=C(SC2N=C(SCC#N)N1C4=CC=C(OC)C=C4)CCCC3. References:...
| Schlagworte: | Nec-5 |
| Anwendung: | Necroptosis inhibitor |
| CAS | 337349-54-9 |
| MW: | 383.49 D |
ab 38,00 €
GSK963
Artikelnummer: TGM-T5054-100mg
Description: GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM). Target: RIP kinase. Smiles: CC(C)(C)C(=O)N1N=CC[C@H]1c1ccccc1. References: Berger SB, et al. Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell...
| Schlagworte: | GSK963 (Racemate) |
| Anwendung: | RIPK1 inhibitor |
| CAS | 2049868-46-2 |
| MW: | 230.31 D |
ab 31,00 €
GSK481
Artikelnummer: TGM-T6852-100mg
Description: GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death. Target: RIP kinase. Smiles: CN1c2ccccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O. References: Harris PA, et al. J Med Chem. 2016, 59(5):2163-2178.
| Schlagworte: | GSK'481 |
| Anwendung: | RIP1 Ser166 phosphorylation inhibitor |
| CAS | 1622849-58-4 |
| MW: | 377.39 D |
ab 33,00 €
Cl-Necrostatin-1
Artikelnummer: TGM-T68520-10mg
Description: Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase. It inhibits RIPK1 activity. Target: Others. Smiles: C(C=1C=2C(NC1)=C(Cl)C=CC2)C3C(=O)N(C)C(=S)N3
| Anwendung: | RIPK1 inhibitor |
| CAS | 862377-51-3 |
| MW: | 293.77 D |
ab 120,00 €
GSK2982772
Artikelnummer: TGM-T7151-100mg
Description: GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively. Target: RIP kinase. Smiles: CN1c2ccccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O. References: Discovery of a First-in-Class Receptor Interacting...
| Anwendung: | RIPK1 inhibitor |
| CAS | 1622848-92-3 |
| MW: | 377.4 D |
ab 67,00 €
Necrostatin 2 racemate
Artikelnummer: TGM-T7504-100mg
Description: Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1. Target: RIP kinase. Smiles: CN1C(=O)NC(Cc2c[nH]c3c(Cl)cccc23)C1=O. References: Takahashi N , Duprez L , Grootjans S , et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use...
| Schlagworte: | Necrostatin-2 racemate |
| Anwendung: | Cell-permeable RIP1 inhibitor |
| CAS | 852391-15-2 |
| MW: | 277.71 D |
ab 58,00 €
GSK547
Artikelnummer: TGM-T7397-100mg
Description: GSK547 (GSK'547) is a highly selective and potent RIP1 kinase inhibitor that disrupts macrophage-mediated adaptive immune tolerance in pancreatic cancer. Target: RIP kinase. Smiles: Fc1cc(F)cc(c1)[C@@H]1CC=NN1C(=O)C1CCN(CC1)c1cc(ncn1)C#N. References: RIP1 Kinase Drives Macrophage-Mediated Adaptive...
| Schlagworte: | GSK'547 |
| Anwendung: | RIPK1 inhibitor |
| CAS | 2226735-55-1 |
| MW: | 396.39 D |
ab 41,00 €
RIPA-56
Artikelnummer: TGM-T7795-100mg
Description: RIPA-56 is an inhibitor of RIP1. Target: RIP kinase. Smiles: CCC(C)(C)C(=O)N(O)Cc1ccccc1. References: Ren Y , Su Y , Sun L , et al. Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response...
| Anwendung: | RIPK1 inhibitor |
| CAS | 1956370-21-0 |
| MW: | 221.3 D |
ab 33,00 €
Necrostatin-34
Artikelnummer: TGM-T9095-100mg
Description: Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain. Target: RIP kinase. Smiles: Cc1ccc(cc1)C1CC(=O)NC(SCC(=O)Nc2nccs2)=C1C#N. References: Huyan Meng, et...
| Schlagworte: | 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 |
| Anwendung: | RIPK1 inhibitor |
| CAS | 375835-43-1 |
| MW: | 384.48 D |
ab 78,00 €
Eclitasertib
Artikelnummer: TGM-T9702-100mg
Description: Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µ?). Target: RIP kinase. Smiles: CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O. References: Anthony A. ESTRADA, et al. Compounds, compositions and methods. WO2017136727A2.
| Anwendung: | Targets receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1] (RIPK1, RIP1) |
| CAS | 2125450-76-0 |
| MW: | 378.38 D |
ab 106,00 €
RIPK1 Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPH-02876-100ug
Description: Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent...
| Schlagworte: | Receptor-interacting serine/threonine-protein kinase 1, Receptor-interacting protein 1, Ripk1, Cell death protein RIP |
| MW: | 78.9 kD |
ab 193,00 €
RIPK1 Protein, Human, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-02007-100ug
Description: RIPK1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.4 kDa and the accession number is Q13546.
| Schlagworte: | RIPK1, Cell death protein RIP, Receptor-interacting protein 1, Receptor-interacting serine/threonine-protein kinase 1 |
| MW: | 49.4 kD |
ab 352,00 €