Zu "K02833" wurden 65 Artikel gefunden!
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Erastin
Artikelnummer: Cay17754-1
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
| Schlagworte: | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone |
| Anwendung: | Antitumor agent |
| CAS | 571203-78-6 |
| MW: | 547.1 D |
ab 60,00 €
RAS GTPase inhibitor 1
Artikelnummer: TGM-T12692-100mg
Description: RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity. Target: Raf. Smiles: C(C(O)=O)(F)(F)F.N([C@H](CC)C1CC1)C=2C3=C(C(=CC=C3)C=4CCNCC4)N=C(NC5=CC(Cl)=C(F)C=C5)N2. References: WATERSON, Alex G, et al. QUINAZOLINE COMPOUNDS AS MODULATORS OF RAS SIGNALING. Patent....
| Anwendung: | RAS GTPase inhibitor |
| CAS | 2252242-32-1 |
| MW: | 565.99 D |
ab 365,00 €
RAS inhibitor Abd-7
Artikelnummer: TGM-T36641-100mg
Description: RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling....
| Anwendung: | RAS inhibitor |
| CAS | 2351843-48-4 |
| MW: | 391.46 D |
ab 228,00 €
Ras inhibitor 134
Artikelnummer: TGM-T77800-50mg
Description: Ras inhibitor 134 can be used in studies about Ras. Target: Others. Smiles: ClC=1C2=C3C(N4[C@@](CN(C(=O)[C@@H]5CN5)CC4)(CCO2)[H])=NC=NC3=CC1C6=C(F)C=CC=C6O. References: Jennifer Pitzen, et al. Preparation of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine and quinazolin-4-amine derivatives as covalent...
| Anwendung: | Ras inhibitor |
| CAS | 2648552-54-7 |
| MW: | 469.9 D |
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ML-210
Artikelnummer: TGM-T8375-100mg
Description: ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis. Target: Glutathione Peroxidase, Ferroptosis, Ras, GPX. Smiles: Cc1onc(C(=O)N2CCN(CC2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1[N+]([O-])=O....
| Schlagworte: | CID 49766530 |
| Anwendung: | HRas(G12V)-expressing cell specific cytotoxin |
| CAS | 1360705-96-9 |
| MW: | 475.32 D |
ab 34,00 €
HRAS Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-02220-100ug
Description: HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It undergoes a continuous cycle of de- and re-palmitoylation, which regulates its...
| Schlagworte: | CTLO, C-HA-RAS1, HRAS1, p21ras, RASH1, C-BAS/HAS, H-RASIDX, Harvey rat sarcoma viral oncogene homolog, C-H-RAS, HAMSV |
| MW: | 22.45 kD |
ab 587,00 €
Kobe2602
Artikelnummer: TGM-T1892-100mg
Description: Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. Target: Raf, Ras. Smiles: [O-][N+](=O)c1cc(cc(c1NNC(=S)Nc1ccc(F)cc1)[N+]([O-])=O)C(F)(F)F. References: Shima F, et al. Proc Natl Acad Sci U S A. 2013 May 14,110(20):8182-7.
| Anwendung: | RAS inhibitor |
| CAS | 454453-49-7 |
| MW: | 419.31 D |
ab 34,00 €
Erastin
Artikelnummer: TGM-T1765-1mg
Description: Erastin is an ferroptosis activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations. The product is unstable in solution and is recommended to be dispensed now. Target: VDAC,...
| Anwendung: | Antitumor agent |
| CAS | 571203-78-6 |
| MW: | 547.04 D |
ab 41,00 €
Kobe0065
Artikelnummer: TGM-T1876-100mg
Description: Kobe0065 is a novel and effective small-molecule compound that inhibits the Ras-Raf interaction by structure-based drug design (SBDD), it displays potent activity, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 µM. Target: Raf, Apoptosis, Ras. Smiles:...
| Anwendung: | Ras inhibitor |
| CAS | 436133-68-5 |
| MW: | 449.79 D |
ab 39,00 €
GTPase HRas (Hras), rat, recombinant
Artikelnummer: CSB-RP155374r.1
Organism: Rattus norvegicus (Rat). Source: E.coli. Expression Region: 2-186aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: TEYKLVVVGA GGVGKSALTI QLIQNHFVDE YDPTIEDSYR KQVVIDGETC LLDILDTAGQ EEYSAMRDQY MRTGEGFLCV FAINNTKSFE DIHQYREQIK RVKDSDDVPM VLVGNKCDLA...
| Schlagworte: | Hras, Hras1, Recombinant Rat GTPase HRas (Hras) |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | rat |
| MW: | 24.9 kD |
ab 283,00 €
Anti-HRAS
Artikelnummer: CSB-PA064824.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: HRAS. Antigen Species: Human
| Schlagworte: | Anti-HRAS, Anti-HRAS1, C BAS/HAS antibody, C HA RAS1 antibody, C-BAS/HAS antibody, c-H-ras antibody, C-HA-RAS1 antibody,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
Anti-Hras
Artikelnummer: CSB-PA15539A0Rb.100
Host Species: Rabbit. Isotype: IgG. Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: >95%, Protein G purified. Target Name: Hras. Antigen Species: Rattus norvegicus (Rat)
| Schlagworte: | Anti-Hras, Anti-Hras1, Hras antibody, Hras1 antibody, GTPase HRas antibody, H-Ras-1 antibody, Transforming protein p21... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | rat, mouse, human |
ab 163,00 €