Zu "K02740" wurden 39 Artikel gefunden!
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Anti-PSMB8
Artikelnummer: ABS-KC-6337.100
Protein function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in...
| Schlagworte: | Anti-Proteasome subunit beta type-8, Anti-Low molecular mass protein 7, Anti-Macropain subunit C13, Anti-Multicatalytic... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, rat |
ab 232,00 €
ONX 0914
Artikelnummer: AG-CR1-3674-M005
Synthetic. Chemical. CAS: 960374-59-8. Formula: C31H40N4O7. MW: 580.7. Synthetic. Potent and selective 20S immunoproteasome inhibitor. Targets the beta5i subunit [LMP7] of the 20S immunoproteasome (IC50=73nM) and with minimal crossreactivity to the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome...
| Schlagworte: | N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosina... |
| Anwendung: | Potent, selective 20S immunoproteasome (PSMB8) inhibitor |
| CAS | 960374-59-8 |
| MW: | 580,7 D |
ab 61,00 €
M3258
Artikelnummer: TGM-T11924-100mg
Description: LMP7-IN-1 may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer, is an inhibitor of immunoproteasome (LMP7). Target: Proteasome. Smiles: OB(O)[C@H](Cc1coc2ccccc12)NC(=O)[C@@H]1C[C@H]2CC[C@@H]1O2. References: Markus Klein, et al....
| Schlagworte: | LMP7-IN-1 |
| Anwendung: | LMP7 (PSMB8, 20S immunoproteasome subunit beta 8/beta-5i) inhibitor |
| CAS | 2285330-15-4 |
| MW: | 329.16 D |
ab 892,00 €
Zetomipzomib
Artikelnummer: TGM-T37419-100mg
Description: KZR-616, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616 has the potential for the research of multiple autoimmune diseases[1][2]. Target: Others. Smiles:...
| Anwendung: | Targets 20S proteasome subunit beta 9 [EC:3.4.25.1] (PSMB9, LMP2) |
| CAS | 1629677-75-3 |
| MW: | 586.68 D |
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Zetomipzomib maleate
Artikelnummer: TGM-T39653-5mg
Description: Zetomipzomib maleate (KZR-616), a novel immunoproteasome inhibitor, effectively and selectively inhibits the LMP7 subunit (hLMP7/mLMP7 IC50: 39/57 nM) and LMP2 subunit (hLMP7/mLMP7 IC50: 131/179 nM) of the immunoproteasome. This compound shows promising potential for research in various autoimmune...
| Schlagworte: | Zetomipzomib maleate, KZR-616 maleate |
| Anwendung: | Targets 20S proteasome subunit beta 9 [EC:3.4.25.1] (PSMB9, LMP2) |
| CAS | 2170983-62-5 |
| MW: | 702.758 D |
1.490,00 €
ONX-0914
Artikelnummer: TGM-T6029-10mg
Description: ONX-0914 (PR-957) is a potent and highly specific immunoproteasome inhibitor with minimal cross-reactivity to the constitutive proteasome. Target: HIV Protease, Antibacterial, Proteasome. Smiles: COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1. References:...
| Schlagworte: | PR-957, ONX0914, ONX 0914 |
| Anwendung: | Potent, selective 20S immunoproteasome (PSMB8) inhibitor |
| CAS | 960374-59-8 |
| MW: | 580.67 D |
ab 48,00 €
PSMB8 Protein, Human, Recombinant (His & Myc & SUMO)
Artikelnummer: TGM-TMPH-01928-100ug
Description: PSMB8 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
| Schlagworte: | Macropain subunit C13, Low molecular mass protein 7, PSMB8, Proteasome subunit beta-5i, Multicatalytic endopeptidase... |
| MW: | 42.7 kD |
ab 198,00 €
Proteasome subunit beta type-8 (PSMB8), human, recombinant
Artikelnummer: CSB-EP018886HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 73-276aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Target Protein Sequence: TTTLAFKFQH GVIAAVDSRA SAGSYISALR VNKVIEINPY LLGTMSGCAA DCQYWERLLA KECRLYYLRN GERISVSAAS KLLSNMMCQY...
| Schlagworte: | LMP7, PSMB8, EC=3.4.25.1, Macropain subunit C13, Proteasome component C13, Proteasome subunit beta-5i, Low molecular mass... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 42.7 kD |
ab 219,00 €
Anti-PSMB8
Artikelnummer: CSB-PA116429.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: PSMB8. Antigen Species: Human
| Schlagworte: | Anti-LMP7, Anti-PSMB8, EC=3.4.25.1, Anti-Macropain subunit C13, Anti-Proteasome component C13, Anti-Proteasome subunit... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 167,00 €
Anti-PSMB8
Artikelnummer: CSB-PA775839.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: PSMB8. Antigen Species: Human
| Schlagworte: | Anti-LMP7, Anti-PSMB8, EC=3.4.25.1, Anti-Macropain subunit C13, Anti-Proteasome component C13, Anti-Proteasome subunit... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Ac-ANW-AMC
Artikelnummer: Cay26640-1
Ac-ANW-AMC is a fluorogenic substrate for the beta5i/LMP7 subunit of the 20S immunoproteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the beta5i/LMP7 subunit of the 20S immunoproteasome. AMC displays excitation/emission maxima of...
| Schlagworte: | Ac-Ala-Asn-Trp-AMC,... |
| Anwendung: | 20S immunoproteasome beta5i/LMP7 fluorogenic substrate |
| MW: | 588.6 D |
ab 78,00 €
ONX 0914
Artikelnummer: Cay16271-5
The immunoproteasome is a specialized, inducible proteasome that generates peptides presented on major histocompatibility complex (MHC) class I molecules to cytotoxic T cells. Stimulation of cells with inflammatory cytokines such as IFN-gamma leads to the replacement of constitutive catalytic proteasome beta...
| Schlagworte: | PR-957,... |
| Anwendung: | Immunoproteasome inhibitor |
| CAS | 960374-59-8 |
| MW: | 580.7 D |
ab 85,00 €