Zu "K02737" wurden 68 Artikel gefunden!
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Lactacystin
Artikelnummer: Cay70980-100
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 µM,...
| Schlagworte: | 3S-hydroxy-2R-(1-hydroxy-2-methylpropyl)-4R-methyl-5-oxo-2-pyrrolidinecarboxylate-N-acetyl-L-cysteine |
| Anwendung: | 20S proteasome inhibitor |
| CAS | 133343-34-7 |
| MW: | 376.4 D |
ab 48,00 €
Bortezomib
Artikelnummer: Cay10008822-5
Bortezomib is a dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM). It binds the beta5-subunit of the 20S proteasome and selectively inhibits chymotryptic activity. In part by blocking the degradation of tumor-suppressing and proapoptotic proteins, bortezomib drives cell...
| Schlagworte: | LDP-341, MG-341, MLN341, NSC 681239, PS-341,... |
| Anwendung: | Proteasome subunit beta type-1/5 inhibitor |
| CAS | 179324-69-7 |
| MW: | 384.2 D |
ab 43,00 €
Clasto-Lactacystin beta-lactone
Artikelnummer: Cay70988-100
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Clasto-lactacystin beta-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive...
| Schlagworte: | 1R-(1S-1hydroxy-2-methylpropyl)-4R-methyl-6-oxa-2-azabicyclo(320)heptane-3,7-dione |
| Anwendung: | Proteasome inhibitor |
| CAS | 154226-60-5 |
| MW: | 213.2 D |
ab 94,00 €
![PS-341 [Bortezomib]](https://www.biomol.com/media/image/e7/b4/85/AG-CR1-3602-M005_200x200.png "PS-341 [Bortezomib]")
PS-341 [Bortezomib]
Artikelnummer: AG-CR1-3602-M005
White solid. Soluble in DMSO, ethanol or methanol. Slightly soluble in water. Highly potent, selective and reversible cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome, Calpain and cathepsin inhibitor, Autophagy activator, Anticancer...
| Schlagworte: | PS-341, LDP-341, MLM-341, MG-341, NSC-681239, Proteasome Inhibitor |
| Anwendung: | Highly potent selective, reversible, cell permeable proteasome inhibitor |
| CAS | 179324-69-7 |
| MW: | 384,2 D |
ab 61,00 €
PI-1840
Artikelnummer: Cay37331-10
PI-1840 is an inhibitor of chymotrypsin-like (CTL) proteasome activity (IC50 = 27 nM). It is selective for the CTL activity over the trypsin-like (TL) and peptidylglutamyl peptide hydrolyzing (PGPH) activities (IC50s = >100 µM for both), as well as for the 20S constitutive proteasome over the immunoproteasome (IC50s...
| Schlagworte: | N-(1-methylethyl)-2-(4-propylphenoxy)-N-[[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]methyl]-acetamide |
| Anwendung: | Chymotrypsin-like proteasome activity inhibitor |
| CAS | 1401223-22-0 |
| MW: | 394.5 D |
ab 81,00 €
Suc-Leu-Leu-Val-Tyr-AMC
Artikelnummer: AG-CP3-0016-M005
Solid lyophilized powder. Soluble in DMSO. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome, calpains and other chymotrypsin-like proteases, Extinction: 380nm. Emission: 460 nm, This substrate is useful for inhibitor screening and kinetic analysis.
| Schlagworte: | Suc-LLVY-AMC, Proteasome Substrate, Calpain Substrate |
| Anwendung: | Fluorogenic proteasome substrate |
| CAS | 94367-21-2 |
| MW: | 763,9 D |
ab 39,00 €
Carfilzomib
Artikelnummer: Cay17554-5
Carfilzomib is a second-generation, irreversible, peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the beta5i subunit of the immunoproteasome 20Si (LMP7, IC50 = 14 nM) with minimal cross reactivity to other...
| Schlagworte: | PR-171,... |
| Anwendung: | Proteasome PSMB5 inhibitor |
| CAS | 868540-17-4 |
| MW: | 719.9 D |
ab 43,00 €
Epoxomicin
Artikelnummer: AG-CN2-0422-C050
White to off-white solid. Soluble in DMSO. Insoluble in water. Antibiotic, Potent anticancer compound, Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome...
| Schlagworte: | Antibiotic BU 4061T |
| Anwendung: | Antibiotic, Anticancer compound, Cell-permeable irreversible 20S proteasome inhibitor |
| CAS | 134381-21-8 |
| MW: | 554,7 D |
ab 83,00 €
Lactacystin
Artikelnummer: AG-CN2-0104-C100
Induces neuritogenesis, Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP, multicatalytic complex). Blocks proteasome activity by targeting the catalytic beta-subunit, apoptosis inducer, anticancer compound, upregulates HSP70 and HSP22, induces differentiation and...
| Anwendung: | Irreversible proteasome inhibitor |
| CAS | 133343-34-7 |
| MW: | 376,4 D |
ab 83,00 €
Suc-Leu-Leu-Val-Tyr-AMC
Artikelnummer: Cay10008119-10
Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases, and calpains (excitation max: 360 nm, emission max: 460 nm).Formal Name: N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-tyrosinamide. CAS Number: 94367-21-2....
| Schlagworte: | Suc-LLVY-AMC, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-tyrosinamide |
| Anwendung: | Fluorescent 20S proteasome substrate |
| CAS | 94367-21-2 |
| MW: | 763.9 D |
ab 46,00 €
Ac-WLA-AMC
Artikelnummer: Cay26639-1
Ac-WLA-AMC is a fluorogenic substrate for the beta5c subunit of the 20S proteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the beta5c subunit of the 20S proteasome. AMC displays excitation/emission maxima of 351/430 nm,...
| Schlagworte: | Acetyl-Trp-Leu-Ala-7-amino-4-Methylcoumarin, Ac-Trp-Leu-Ala-AMC,... |
| Anwendung: | 20S proteasome beta5 fluorogenic substrate |
| CAS | 1104011-59-7 |
| MW: | 587.7 D |
ab 77,00 €
Salinosporamide A
Artikelnummer: Cay10007311-100
Salinosporamide A is a natural proteasome inhibitor. It is a beta-lactone-gamma-lactam that irreversibly inhibits all three protease activities within the proteasome (IC50s = 3.5, 28, and 430 nM for beta5 (chymotrypsin), beta2 (macropain), and beta1 (C5) subunits, respectively), both in vitro and in vivo....
| Schlagworte: | Marizomib, ML-858, NPI-0052,... |
| Anwendung: | Natural proteasome inhibitor, PSMB5 / PSMB2 / PSMB1 inhibitor |
| CAS | 437742-34-2 |
| MW: | 313.8 D |
222,00 €